Search Results - "SHOEMAKER, Alex R"

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models by SHOEMAKER, Alex R, MITTEN, Michael J, BAUCH, Joy, MARSH, Kennan, TAHIR, Steven K, XIUFENYANG, TSE, Christin, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, ADICKES, Jessica, ACKLER, Scott, REFICI, Marion, FERGUSON, Debra, OLEKSIJEW, Anatol, O'CONNOR, Jacqueline M, BAOLE WANG, FROST, David J

“…Purpose: The purpose of this study was to characterize the activity of the Bcl-2 protein family inhibitor ABT-263 in a panel of small cell lung cancer (SCLC)…”
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ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo by Ackler, Scott, Xiao, Yu, Mitten, Michael J, Foster, Kelly, Oleksijew, Anatol, Refici, Marion, Schlessinger, Sally, Wang, Baole, Chemburkar, Sanjay R, Bauch, Joy, Tse, Christin, Frost, David J, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W, Shoemaker, Alex R

“…ABT-263 is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x L , and Bcl-w, which is currently in phase I clinical…”
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Hypoxia-Inducible Factor-1 Inhibition in Combination with Temozolomide Treatment Exhibits Robust Antitumor Efficacy In vivo by LEIMING LI, XIAOYU LIN, SHOEMAKER, Alex R, ALBERT, Daniel H, FESIK, Stephen W, YU SHEN

“…Purpose: Inhibiting hypoxia-inducible factor-1 (HIF-1) represents a unique mechanism for cancer therapy. It is conceived that HIF-1 inhibitors may synergize…”
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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity by Bromberg, Kenneth D, Mitchell, Taylor R H, Upadhyay, Anup K, Jakob, Clarissa G, Jhala, Manisha A, Comess, Kenneth M, Lasko, Loren M, Li, Conglei, Tuzon, Creighton T, Dai, Yujia, Li, Fengling, Eram, Mohammad S, Nuber, Alexander, Soni, Niru B, Manaves, Vlasios, Algire, Mikkel A, Sweis, Ramzi F, Torrent, Maricel, Schotta, Gunnar, Sun, Chaohong, Michaelides, Michael R, Shoemaker, Alex R, Arrowsmith, Cheryl H, Brown, Peter J, Santhakumar, Vijayaratnam, Martin, Alberto, Rice, Judd C, Chiang, Gary G, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Pappano, William N

“…Editorial Summary SUV4-20 members mediate the di- and trimethylation of lysine 20 on histone H4. A chemical screen led to the identification of A-196 as a…”
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Tumor Regionality in the Mouse Intestine Reflects the Mechanism of Loss of Apc Function by Haigis, Kevin M., Hoff, Peter D., White, Alanna, Shoemaker, Alex R., Halberg, Richard B., Dove, William F.

“…Inherited colorectal cancer syndromes in humans exhibit regional specificity for tumor formation. By using mice with germline mutations in the adenomatous…”
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The HPK1 Inhibitor A‑745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy by Malchow, Sven, Korepanova, Alla, Panchal, Sanjay C, McClure, Ryan A, Longenecker, Kenton L, Qiu, Wei, Zhao, Hongyu, Cheng, Min, Guo, Jun, Klinge, Kelly L, Trusk, Patricia, Pratt, Steven D, Li, Tao, Kurnick, Matthew D, Duan, Lishu, Shoemaker, Alex R, Gopalakrishnan, Sujatha M, Warder, Scott E, Shotwell, J. Brad, Lai, Albert, Sun, Chaohong, Osuma, Augustine T, Pappano, William N

“…Hematopoietic progenitor kinase 1 (HPK1) is an MAP4K family member within the Ste20-like serine/threonine branch of the kinome. HPK1 expression is limited to…”
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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo by SHOEMAKER, Alex R, OLEKSIJEW, Anatol, MARSH, Kennan, MCCLELLAN, William, NELLANS, Hugh, NG, Shichung, NIMMER, Paul, O'CONNOR, Jacqueline M, OLTERSDORF, Tilman, WEIGUO QING, WANG SHEN, STAVROPOULOS, Jason, BAUCH, Joy, TAHIR, Stephen K, BAOLE WANG, WARNER, Robert, HAICHAO ZHANG, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, BELLI, Barbara A, BORRE, Tony, BRUNCKO, Milan, DECKWIRTH, Thomas, FROST, David J, JARVIS, Ken, JOSEPH, Mary K

“…Inhibition of the prosurvival members of the Bcl-2 family of proteins represents an attractive strategy for the treatment of cancer. We have previously…”
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PARP inhibitors attenuate chemotherapy-induced painful neuropathy by Brederson, Jill-Desiree, Joshi, Shailen K., Browman, Kaitlin E., Mikusa, Joseph, Zhong, Chengmin, Gauvin, Donna, Liu, Xuesong, Shi, Yan, Penning, Thomas D., Shoemaker, Alex R., Giranda, Vincent L.

“…Chemotherapy‐induced peripheral neuropathy (CIPN) is a major toxicity of chemotherapy treatment for which no therapy is approved. Poly(ADP‐ribose) polymerase…”
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Studies of neoplasia in the Min mouse by Shoemaker, Alex R, Gould, Karen A, Luongo, Cindy, Moser, Amy R, Dove, William F

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A Resistant Genetic Background Leading to Incomplete Penetrance of Intestinal Neoplasia and Reduced Loss of Heterozygosity in ApcMin/+ Mice by Shoemaker, Alex R., Moser, Amy R., Midgley, Carol A., Clipson, Linda, Newton, Michael A., Dove, William F.

“…Previous studies of Min/+ (multiple intestinal neoplasia) mice on a sensitive genetic background, C57BL/6 (B6), showed that adenomas have lost heterozygosity…”
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N-ethyl-N-nitrosourea treatment of multiple intestinal neoplasia (Min) mice : age-related effects on the formation of intestinal adenomas : cystic crypts, and epidermoid cysts by SHOEMAKER, A. R, MOSER, A. R, DOVE, W. F

“…The timing of intestinal tumor initiation in B6-Min/+ mice has been examined by treating mice at 5-35 days of age with a single i.p. injection of the…”
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Somatic mutational mechanisms involved in intestinal tumor formation in Min mice by SHOEMAKER, A. R, LUONGO, C, MOSER, A. R, MARTON, L. J, DOVE, W. F

“…We have demonstrated previously that intestinal tumor formation in B6 Min/+ mice is always accompanied by loss of the wild-type adenomatous polyoposis coli…”
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Manipulation of the mouse germline in the study ofMin-induced neoplasia by Bilger, Andrea, Shoemaker, Alex R., Gould, Karen A., Dove, William F.

“…The Min mouse, generated by random germline mutagenesis, carries a mutation in the mouse homolog of APC and is a model of inherited human intestinal…”
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Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation by Moser, Amy Rapaich, Shoemaker, Alex R., Connelly, Camille S., Clipson, Linda, Gould, Karen A., Luongo, Cindy, Dove, William F., Siggers, Pamela H., Gardner, Richard L.

“…Mutation of the APC (adenomatous polyposis coli) gene is an early event in colon tumor development in humans. Mice carrying Min (multiple intestinal…”
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The Bcl-2 Family Inhibitor ABT-263 Shows Significant Anti-Tumor Efficacy in Models of B Cell Non-Hodgkin's Lymphoma by Shoemaker, Alex R., Mitten, Michael J., Oleksijew, Anatol, O'Connor, Jacqeuline M., Wang, Baole, Ackler, Scott, Joseph, Mary, Zhang, Haichao, Nimmer, Paul, Xiao, Yu, Tse, Christin, Frost, David J., Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W.

“…ABT-263 is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins with a Ki of ≤ 1 nM against Bcl-2, Bcl-XL, and Bcl-w. Non-Hodgkin's B-cell…”
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The Bcl-2 Family Inhibitor ABT-263 Shows Significant but Reversible Thrombocytopenia in Mice by Shoemaker, Alex R., Mitten, Michael J., Adickes, Jessica, Oleksijew, Anatol, Zhang, Haichao, Bauch, Joy, Marsh, Kennan, Frost, David J., Madar, David, Tse, Christin, Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W.

“…ABT-263 is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins with a Ki of ≤ 1 nM against Bcl-2, Bcl-XL, and Bcl-w. Potent cytotoxic…”
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Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice by Shoemaker, A R, Haigis, K M, Baker, S M, Dudley, S, Liskay, R M, Dove, W F

“…Defects in APC and DNA mismatch repair genes are associated with a strong predisposition to colon cancer in humans, and numerous mouse strains with mutations…”
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Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation by Moser, A R, Shoemaker, A R, Connelly, C S, Clipson, L, Gould, K A, Luongo, C, Dove, W F, Siggers, P H, Gardner, R L

“…Mutation of the APC (adenomatous polyposis coli) gene is an early event in colon tumor development in humans. Mice carrying Min (multiple intestinal…”
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Manipulation of the mouse germline in the study of Min-induced neoplasia by Bilger, A, Shoemaker, A R, Gould, K A, Dove, W F

“…The Min mouse, generated by random germline mutagenesis, carries a mutation in the mouse homolog of APC and is a model of inherited human intestinal…”
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A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in Apc Min /+ mice by Shoemaker, Alex R., Moser, Amy R., Midgley, Carol A., Clipson, Linda, Newton, Michael A., Dove, William F.

“…Previous studies of Min /+ (multiple intestinal neoplasia) mice on a sensitive genetic background, C57BL/6 (B6), showed that adenomas have lost heterozygosity…”
Get full text