Search Results - "SHODA, Toshiyuki"

Deep learning-based image-analysis algorithm for classification and quantification of multiple histopathological lesions in rat liver by Shimazaki, Taishi, Deshpande, Ameya, Hajra, Anindya, Thomas, Tijo, Muta, Kyotaka, Yamada, Naohito, Yasui, Yuzo, Shoda, Toshiyuki

“…Artificial intelligence (AI)-based image analysis is increasingly being used for preclinical safety-assessment studies in the pharmaceutical industry. In this…”
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Spontaneous histiocytic sarcoma originating from the epididymis in a CD-1 mouse by Shimazaki, Taishi, Yasui, Yuzo, Anagawa-Nakamura, Akiko, Toyoda, Kaoru, Yamazaki, Ryo, Onami, Saeko, Kemmochi, Yusuke, Shoda, Toshiyuki

“…We report a histiocytic sarcoma originating from the epididymis observed in a 110-week-old male CD-1 mouse in a carcinogenicity study. At necropsy, no lesions…”
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High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats by Toyoda, Kaoru, Suzuki, Yusuke, Muta, Kyotaka, Masuyama, Taku, Kakimoto, Kochi, Kobayashi, Akio, Shoda, Toshiyuki, Sugai, Shoichiro

“…Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple…”
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Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury by Goda, Keisuke, Takahashi, Tadakazu, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Drug-induced liver injury (DILI) is one of the serious and frequent drug-related adverse events. This adverse event is a main reason for regulatory action…”
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A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor by Yokoyama, Hideaki, Kobayashi, Akio, Kondo, Kazuma, Oshida, Shin-ichi, Takahashi, Tadakazu, Masuyama, Taku, Shoda, Toshiyuki, Sugai, Shoichiro

“…Acyl CoA: diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the re-synthesis of triglycerides (TG) from free fatty acids and diacylglycerol…”
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Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats by Kemmochi, Yusuke, Ohta, Takeshi, Motohashi, Yu, Kaneshige, Akihiro, Katsumi, Sohei, Kakimoto, Kochi, Yasui, Yuzo, Anagawa-Nakamura, Akiko, Toyoda, Kaoru, Taniai-Riya, Eriko, Takahashi, Akemi, Shoda, Toshiyuki, Yamada, Takahisa

“…Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the…”
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Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat by Taniai-Riya, Eriko, Miyajima, Katsuhiro, Kakimoto, Kochi, Ohta, Takeshi, Yasui, Yuzo, Kemmochi, Yusuke, Anagawa-Nakamura, Akiko, Toyoda, Kaoru, Takahashi, Akemi, Shoda, Toshiyuki

“…The Spontaneously Diabetic Torii (SDT) rat is a rat model of nonobese type 2 diabetes mellitus, and hepatocellular adenomas have not been reported in this…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Toyoda, Kaoru, Hashimoto, Tatsuji, Takahashi, Akemi, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent. However, some patients encounter hepatotoxicity after repeated APAP…”
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Ocular Inflammation in Uveal Tract in Aged Obese Type 2 Diabetic Rats (Spontaneously Diabetic Torii Fatty Rats) by Kakehashi, Akihiro, Shoda, Toshiyuki, Toyoda, Kaoru, Yasui, Yuzo, Sasase, Tomohiko, Ohta, Takeshi, Miyajima, Katsuhiro, Kemmochi, Yusuke, Kakimoto, Kochi

“…We report uveitis observed in an obese type 2 diabetes rat model, Spontaneously Diabetic Torii Leprfa (SDT fatty) rats aged over 50 weeks. The eyes of SDT…”
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Spontaneous Histiocytic Sarcoma of the Popliteal Lymph Node in a Young Sprague-Dawley Rat by Kemmochi, Yusuke, Takahashi, Akemi, Miyajima, Katsuhiro, Yasui, Yuzo, Tanoue, Gimpei, Shoda, Toshiyuki, Kakimoto, Kochi

“…The present report describes a rare case of spontaneous primary histiocytic sarcoma of the popliteal lymph node in a 19-week-old female Sprague-Dawley (SD)…”
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Effect of Insulin Therapy on Renal Changes in Spontaneously Diabetic Torii Rats by OHTA, Takeshi, MATSUI, Kenichi, MIYAJIMA, Katsuhiro, SASASE, Tomohiko, MASUYAMA, Taku, SHODA, Toshiyuki, KOIZUMI, Haruko, SHINOHARA, Masami, MATSUSHITA, Mutsuyoshi

“…The spontaneously diabetic Torii (SDT) rat has recently been established as an animal model of non-obese type 2 diabetes, in which ocular complications severe…”
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Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats by Yusuke Kemmochi, Takeshi Ohta, Yu Motohashi, Akihiro Kaneshige, Sohei Katsumi, Kochi Kakimoto, Yuzo Yasui, Akiko Anagawa-Nakamura, Kaoru Toyoda, Eriko Taniai-Riya, Akemi Takahashi, Toshiyuki Shoda, Takahisa Yamada

“…[Abstract] : Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia,…”
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Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat by Eriko Taniai-Riya, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta, Yuzo Yasui, Yusuke Kemmochi, Akiko Anagawa-Nakamura, Kaoru Toyoda, Akemi Takahashi, Toshiyuki Shoda

“…[Abstract]: The Spontaneously Diabetic Torii (SDT) rat is a rat model of nonobese type 2 diabetes mellitus, and hepatocellular adenomas have not been reported…”
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Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951), a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor, in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study by Kemmochi, Yusuke, Toyoda, Kaoru, Ishida, Tomio, Yasui, Yuzo, Shoda, Toshiyuki

“…Enarodustat (JTZ-951) is an oral hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor for the treatment of anemia with chronic kidney disease…”
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Histopathological Features of Diabetic Ocular Complications in the Spontaneously Diabetic Torii (SDT) Rat by Shoda, Toshiyuki, Shinohara, Masami, Takahashi, Tadakazu, Miyajima, Katsuhiro, Kakehashi, Akihiro, Miyakawa, Yoshifumi

“…The Spontaneously Diabetic Torii (SDT) rat is a novel rat model recently established for type 2 diabetes mellitus. In this report, we describe the unique…”
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Effects of Delgocitinib Ointment 0.5% on the Normal Mouse Skin and Epidermal Tight Junction Proteins in Comparison With Topical Corticosteroids by Anagawa-Nakamura, Akiko, Ryoke, Katsunori, Yasui, Yuzo, Shoda, Toshiyuki, Sugai, Shoichiro

“…Delgocitinib ointment 0.5% is the world’s first topical Janus kinase inhibitor product and was approved for treatment of atopic dermatitis (AD) in Japan…”
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Liver Tumor Promoting Effects of Fenbendazole in Rats by Shoda, Toshiyuki, Onodera, Hiroshi, Takeda, Makio, Uneyama, Chikako, Imazawa, Takayoshi, Takegawa, Kiyoshi, Yasuhara, Kazuo, Watanabe, Tomoyuki, Hirose, Masao, Mitsumori, Kunitoshi

“…In order to examine whether fenbendazole has tumor-promoting activity, a total of 70 male Fischer 344 rats were initiated with a single intraperitoneal…”
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Spontaneous histiocytic sarcoma originating from the epididymis in a CD-1 mouse by SHIMAZAKI, Taishi, YASUI, Yuzo, ANAGAWA-NAKAMURA, Akiko, TOYODA, Kaoru, YAMAZAKI, Ryo, ONAMI, Saeko, KEMMOCHI, Yusuke, SHODA, Toshiyuki

“…We report a histiocytic sarcoma originating from the epididymis observed in a 110-week-old male CD-1 mouse in a carcinogenicity study. At necropsy, no lesions…”
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Deep learning-based image-analysis algorithm for classification and quantification of multiple histopathological lesions in rat liver by SHIMAZAKI, Taishi, DESHPANDE, Ameya, HAJRA, Anindya, THOMAS, Tijo, MUTA, Kyotaka, YAMADA, Naohito, YASUI, Yuzo, SHODA, Toshiyuki

“…Artificial intelligence (AI)-based image analysis is increasingly being used for preclinical safety-assessment studies in the pharmaceutical industry. In this…”
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Immunohistochemical Characterization of Spontaneous Sertoli Cell Clusters in the Seminiferous Tubules of C57BL/6J Mice by Anagawa-Nakamura, Akiko, Kakimoto, Kochi, Miyajima, Katsuhiro, Yasui, Yuzo, Kemmochi, Yusuke, Toyoda, Kaoru, Taniai, Eriko, Takahashi, Akemi, Shoda, Toshiyuki

“…Cell clusters were observed in the seminiferous tubules of C57BL/6J mice as a spontaneous lesion in a 2-week toxicity study, and they were demonstrated to be…”
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