Search Results - "SHMUEL MUALLEM"

Lipids at membrane contact sites: cell signaling and ion transport by Muallem, Shmuel, Chung, Woo Young, Jha, Archana, Ahuja, Malini

“…Communication between organelles is essential to coordinate cellular functions and the cell's response to physiological and pathological stimuli. Organellar…”
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Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion by Lee, Min Goo, Ohana, Ehud, Park, Hyun Woo, Yang, Dongki, Muallem, Shmuel

“…Fluid and HCO(3)(-) secretion is a vital function of all epithelia and is required for the survival of the tissue. Aberrant fluid and HCO(3)(-) secretion is…”
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Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment by Jha, Archana, Chung, Woo Young, Vachel, Laura, Maleth, Jozsef, Lake, Sarah, Zhang, Guofeng, Ahuja, Malini, Muallem, Shmuel

“…Communication and material transfer between membranes and organelles take place at membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM…”
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Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers by Penny, Christopher J., Vassileva, Kristin, Jha, Archana, Yuan, Yu, Chee, Xavier, Yates, Elizabeth, Mazzon, Michela, Kilpatrick, Bethan S., Muallem, Shmuel, Marsh, Mark, Rahman, Taufiq, Patel, Sandip

“…Two-pore channels (TPCs) are Ca2+-permeable ion channels localised to the endo-lysosomal system where they regulate trafficking of various cargoes including…”
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SOAR and the polybasic STIM1 domains gate and regulate Orai channels by Yuan, Joseph P, Zeng, Weizhong, Dorwart, Michael R, Choi, Young-Jin, Worley, Paul F, Muallem, Shmuel

“…Influx of Ca2+ through store-operated Ca2+ channels (SOCs) is a central component of receptor-evoked Ca2+ signals. Orai channels are SOCs that are gated by…”
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Diverse transport modes by the solute carrier 26 family of anion transporters by Ohana, Ehud, Yang, Dongki, Shcheynikov, Nikolay, Muallem, Shmuel

“…The solute carrier 26 (SLC26) transporters are anion transporters with diverse substrate specificity. Several members are ubiquitous while others show limited…”
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Opening the Orai1 gates by Muallem, Shmuel, Jha, Archana

“…How the store-operated channel Orai1 opens and the number of gates that control channel opening and conductance remain unclear. In this issue of , Frischauf…”
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Mechanism and synergism in epithelial fluid and electrolyte secretion by Hong, Jeong Hee, Park, Seonghee, Shcheynikov, Nikolay, Muallem, Shmuel

“…A central function of epithelia is the control of the volume and electrolyte composition of bodily fluids through vectorial transport of electrolytes and the…”
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CFTR does it again： control of insulin secretion by Muallem, Shmuel

“…A major breakthrough in understanding diabetes mellitus, especially in the disease cystic fibrosis （CF） was made recently by the group of Dr. Hsiao Chang Chan…”
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STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels by Huang, Guo N, Zeng, Weizhong, Kim, Joo Young, Yuan, Joseph P, Han, Linhuang, Muallem, Shmuel, Worley, Paul F

“…Receptor-evoked Ca2+ signalling involves Ca2+ release from the endoplasmic reticulum, followed by Ca2+ influx across the plasma membrane. Ca2+ influx is…”
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The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function by Jha, Archana, Ahuja, Malini, Maléth, József, Moreno, Claudia M, Yuan, Joseph P, Kim, Min Seuk, Muallem, Shmuel

“…Ca(2+) influx by store-operated Ca(2+) channels (SOCs) mediates all Ca(2+)-dependent cell functions, but excess Ca(2+) influx is highly toxic. The molecular…”
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Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na⁺-HCO₃⁻ cotransporters family by Hong, Jeong Hee, Yang, Dongki, Shcheynikov, Nikolay, Ohana, Ehud, Shin, Dong Min, Muallem, Shmuel

“…Fluid and HCO ₃⁻ secretion is a vital function of secretory epithelia, involving basolateral HCO ₃⁻ entry through the Na ⁺-HCO ₃⁻ cotransporter (NBC) NBCe1-B,…”
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cAMP and Ca2+ signaling in secretory epithelia: Crosstalk and synergism by Ahuja, Malini, Jha, Archana, Maléth, Jozsef, Park, Seonghee, Muallem, Shmuel

“…Abstract The Ca2+ and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions…”
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Intracellular Cl⁻ as a signaling ion that potently regulates Na⁺/HCO3⁻ transporters by Shcheynikov, Nikolay, Son, Aran, Hong, Jeong Hee, Yamazaki, Osamu, Ohana, Ehud, Kurtz, Ira, Shin, Dong Min, Muallem, Shmuel

“…Cl⁻ is a major anion in mammalian cells involved in transport processes that determines the intracellular activity of many ions and plasma membrane potential…”
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Molecular Determinants Mediating Gating of Transient Receptor Potential Canonical (TRPC) Channels by Stromal Interaction Molecule 1 (STIM1) by Lee, Kyu Pil, Choi, Seok, Hong, Jeong Hee, Ahuja, Malini, Graham, Sarabeth, Ma, Rong, So, Insuk, Shin, Dong Min, Muallem, Shmuel, Yuan, Joseph P.

“…Transient receptor potential canonical (TRPC) channels mediate a critical part of the receptor-evoked Ca2+ influx. TRPCs are gated open by the endoplasmic…”
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Solute Carrier Family 26 Member a2 (Slc26a2) Protein Functions as an Electroneutral SO42−/OH−/Cl− Exchanger Regulated by Extracellular Cl by Ohana, Ehud, Shcheynikov, Nikolay, Park, Meeyoung, Muallem, Shmuel

“…Slc26a2 is a ubiquitously expressed SO42− transporter with high expression levels in cartilage and several epithelia. Mutations in SLC26A2 are associated with…”
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Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction by Son, Aran, Park, Seonghee, Shin, Dong Min, Muallem, Shmuel

“…Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma…”
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An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs by Lee, Kyu Pil, Yuan, Joseph P., Hong, Jeong Hee, So, Insuk, Worley, Paul F., Muallem, Shmuel

“…Ca 2+ entering cells through store-operated channels (SOCs) affects most cell functions, and excess SOC is associated with pathologies. The molecular makeup of…”
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Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1 by Rybalchenko, Volodymyr, Ahuja, Malini, Coblentz, Jessica, Churamani, Dev, Patel, Sandip, Kiselyov, Krill, Muallem, Shmuel

“…Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent second messenger that mobilizes Ca2+ from the acidic endolysosomes by activation of the…”
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RANKL-mediated Reactive Oxygen Species Pathway That Induces Long Lasting Ca2+ Oscillations Essential for Osteoclastogenesis by Kim, Min Seuk, Yang, Yu-Mi, Son, Aran, Tian, Yu Shun, Lee, Syng-Ill, Kang, Sang Won, Muallem, Shmuel, Shin, Dong Min

“…RANKL (receptor activator of NF-κB ligand) induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among…”
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