Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel dise...

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Bibliographic Details
Published in:Annals of human genetics Vol. 62; no. 4; pp. 291 - 298
Main Authors: CAVANAUGH, J. A., CALLEN, D. F., WILSON, S. R., STANFORD, P. M., SRAML, M. E., GORSKA, M., CRAWFORD, J., WHITMORE, S. A., SHLEGEL, C., FOOTE, S., KOHONEN-CORISH, M., PAVLI, P.
Format: Journal Article
Language:English
Published: Edinburgh, UK Cambridge University Press 01-07-1998
Blackwell Science Ltd
Subjects:
Australia
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 16
Crohn Disease - genetics
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Inflammatory Bowel Diseases - genetics
Lod Score
Male
Medical sciences
Other diseases. Semiology
Pedigree
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Australia
Oceania
Genetic mapping
Human
Family study
Necrotizing enterocolitis
Genetic determinism
Inflammatory disease
Crohn disease
Newborn
Chromosome E16
Predisposition
Digestive diseases
Genetics
Intestinal disease
Haplotype
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Description
Summary:A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.
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ISSN:0003-4800
1469-1809
DOI:10.1046/j.1469-1809.1998.6240291.x