Search Results - "SHLAFER, M"

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion by GALLAGHER, K. P, BUDA, A. J, PACE, D, GERREN, R. A, SHLAFER, M

“…Superoxide dismutase (SOD) and catalase (CAT), enzymes that degrade superoxide anion and hydrogen peroxide, respectively, reduce size of infarction in…”
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Myocardial Flavin Reductase and Riboflavin: A Potential Role in Decreasing Reoxygenation Injury by Mack, C.P., Hultquist, D.E., Shlafer, M.

“…Ferrylmyoglobin has been implicated in cardiac reoxygenation damage. Flavin reductase, an enzyme previously isolated from erythrocytes, can reduce…”
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Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart by Shlafer, M, Kane, P F, Kirsh, M M

“…Experiments were conducted in an attempt to improve upon the contractile and metabolic protection of globally ischemic and reperfused isolated hearts provided…”
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Mitochondrial hydrogen peroxide generation and activities of glutathione peroxidase and superoxide dismutase following global ischemia by Shlafer, M, Myers, C L, Adkins, S

“…We used isolated, buffer-perfused rabbit hearts to evaluate whether global, normothermic ischemia altered mitochondrial hydrogen peroxide (H2O2) generation and…”
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Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts by Myers, C L, Weiss, S J, Kirsh, M M, Shepard, B M, Shlafer, M

“…We evaluated whether supplemental pharmacologic interventions that altered formation or degradation of reactive oxygen metabolites, when added to hypothermic…”
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Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury by Shlafer, M, Kane, P F, Wiggins, V Y, Kirsh, M M

“…Parabiotically perfused, isolated cat hearts were subjected to global ischemia for 2 hours at 27 degrees C and were then reperfused for 2 hours. One group of…”
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Cerium chloride as a histochemical marker of hydrogen peroxide in reperfused ischemic hearts by Shlafer, M, Brosamer, K, Forder, J R, Simon, R H, Ward, P A, Grum, C M

“…Hydrogen peroxide (H2O2) has been implicated in cardiac damage due to ischemia and reperfusion. We adapted an electron microscopic, histochemical method for…”
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Human neutrophil hydrogen peroxide generation following physical exercise by Macha, M, Shlafer, M, Kluger, M J

“…The effects of prolonged, submaximal exercise by seven healthy, untrained individuals on the generation of H2O2 by neutrophils was studied. Hydrogen peroxide…”
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The oxygen consumption paradox of stunned myocardium in dogs by DEAN, E. N, SHLAFER, M, NICKLAS, J. M

“…The contractile state of the heart is a major determinant of myocardial oxygen consumption. Since regional myocardial contractility can be severely impaired…”
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Subcellular actions and potential adverse cardiac effects of the cardiotonic ionophore monensin by Shlafer, M, Kane, P

“…Monensin concentrations between 0.5 and 30 microM produced dose-dependent positive inotropy when administered to normal, electrically driven rabbit left atria…”
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Ultrastructural demonstration of peroxidative activity and peroxidation in ischaemic and ischaemic-reperfused rabbit hearts by Mack, C P, Brosamer, K M, Shlafer, M

“…The aim was to characterise subcellular histochemical evidence of the involvement of peroxidation and peroxidases in myocardial reperfusion injury. The…”
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Hydrogen peroxide generation by mitochondria isolated from regionally ischemic and nonischemic dog myocardium by SHLAFER, M, GALLAGHER, K. P, ADKINS, S

“…We occluded the left anterior descending coronary artery of anesthetized, open-chest dogs, for 1 or 2 h. Some hearts were reperfused for 1 h after 1 h of…”
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Protective effects of diltiazem during myocardial ischemia in isolated cat hearts by Bush, L R, Li, Y P, Shlafer, M, Jolly, S R, Lucchesi, B R

“…The protective effects of diltiazem, a calcium channel blocker, were studied in isolated, blood-perfused cat hearts subjected to 60 or 90 min of global…”
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Purine efflux after cardiac ischemia: relevance to allopurinol cardioprotection by Grum, C M, Ketai, L H, Myers, C L, Shlafer, M

“…Allopurinol is thought to protect hearts against damage due to hypoxia or ischemia by inhibiting xanthine oxidase and oxygen radical generation. We subjected…”
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The functional border zone in conscious dogs by GALLAGHER, K. P, GERREN, R. A, XUE-HAN NING, MCMANIMON, S. P, STIRLING, M. C, SHLAFER, M, BUDA, A. J

“…Studies focusing on the functional border zone have been performed largely with anesthetized, open-chest preparations. Therefore, we instrumented 14 dogs at…”
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Drugs that modify cellular responses to low temperature (cryoprotectants): a pharmacological perspective of preserving biological systems by freezing by Shlafer, M

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The effect of hypothermic ischemia on recovery of left ventricular function and preload reserve in the neonatal heart by Bove, E L, Gallagher, K P, Drake, D H, Lynch, M J, Fox, M, Forder, J, Bolling, S F, Shlafer, M

“…Neonatal and adult myocardium respond differently to ischemia. In addition, the neonatal heart possesses a limited preload reserve. The effect of uninterrupted…”
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Hemodynamic effects of intraatrial administration of deferoxamine or deferoxamine-pentafraction conjugate to conscious dogs by Forder, J R, McClanahan, T B, Gallagher, K P, Hedlund, B E, Hallaway, P E, Shlafer, M

“…Deferoxamine (DFX) is a specific Fe3+ chelator that is used to manage iron overload, and is being evaluated as an agent to reduce ischemic organ damage that…”
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Respiratory effects of hexachlorocyclopentadiene on intact rainbow trout (Salmo gairdneri) and on oxidative phosphorylation of isolated trout heart mitochondria by Sinhaseni, P, D'Alecy, L G, Hartung, R, Shlafer, M

“…Acclimated normal rainbow trout were exposed to 130 ppb hexachlorocyclopentadiene (HEX) in a flow-through well water circuit which was designed to permit…”
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Effects of carboxylic ionophore monensin on atrial contractility and Ca2+ regulation by isolated cardiac microsomes by Shlafer, M, Somani, P, Pressman, B C, Palmer, R F

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