Search Results - "SHKURA, Kirill"

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target by Srivastava, Prashant K., van Eyll, Jonathan, Godard, Patrice, Mazzuferi, Manuela, Delahaye-Duriez, Andree, Van Steenwinckel, Juliette, Gressens, Pierre, Danis, Benedicte, Vandenplas, Catherine, Foerch, Patrik, Leclercq, Karine, Mairet-Coello, Georges, Cardenas, Alvaro, Vanclef, Frederic, Laaniste, Liisi, Niespodziany, Isabelle, Keaney, James, Gasser, Julien, Gillet, Gaelle, Shkura, Kirill, Chong, Seon-Ah, Behmoaras, Jacques, Kadiu, Irena, Petretto, Enrico, Kaminski, Rafal M., Johnson, Michael R.

“…The identification of drug targets is highly challenging, particularly for diseases of the brain. To address this problem, we developed and experimentally…”
Get full text

Describing the genetic architecture of epilepsy through heritability analysis by SPEED, Doug, O'BRIEN, Terence J, PALOTIE, Aarno, SHKURA, Kirill, MARSON, Anthony G, BALDING, David J, JOHNSON, Michael R

“…Epilepsy is a disease with substantial missing heritability; despite its high genetic component, genetic association studies have had limited success detecting…”
Get full text

AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury by Kong, Guiping, Zhou, Luming, Serger, Elisabeth, Palmisano, Ilaria, De Virgiliis, Francesco, Hutson, Thomas H., Mclachlan, Eilidh, Freiwald, Anja, La Montanara, Paolo, Shkura, Kirill, Puttagunta, Radhika, Di Giovanni, Simone

“…Regeneration after injury occurs in axons that lie in the peripheral nervous system but fails in the central nervous system, thereby limiting functional…”
Get full text

Purification of mouse axoplasmic proteins from dorsal root ganglia nerves for proteomics analysis by Kong, Guiping, Zhou, Luming, Freiwald, Anja, Shkura, Kirill, Di Giovanni, Simone

“…The study of neuronal signaling ex vivo requires the identification of the proteins that are represented within the neuronal axoplasm. Here, we describe a…”
Get full text

Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling by Chen, Huimei, Moreno-Moral, Aida, Pesce, Francesco, Devapragash, Nithya, Mancini, Massimiliano, Heng, Ee Ling, Rotival, Maxime, Srivastava, Prashant K., Harmston, Nathan, Shkura, Kirill, Rackham, Owen J. L., Yu, Wei-Ping, Sun, Xi-Ming, Tee, Nicole Gui Zhen, Tan, Elisabeth Li Sa, Barton, Paul J. R., Felkin, Leanne E., Lara-Pezzi, Enrique, Angelini, Gianni, Beltrami, Cristina, Pravenec, Michal, Schafer, Sebastian, Bottolo, Leonardo, Hubner, Norbert, Emanueli, Costanza, Cook, Stuart A., Petretto, Enrico

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Integrated systems‐genetic analyses reveal a network target for delaying glioma progression by Laaniste, Liisi, Srivastava, Prashant K., Stylianou, Julianna, Syed, Nelofer, Cases‐Cunillera, Silvia, Shkura, Kirill, Zeng, Qingyu, Rackham, Owen J. L., Langley, Sarah R., Delahaye-Duriez, Andree, O'Neill, Kevin, Williams, Matthew, Becker, Albert, Roncaroli, Federico, Petretto, Enrico, Johnson, Michael R.

“…Objective To identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy discovery…”
Get full text

Epigenomic signatures underpin the axonal regenerative ability of dorsal root ganglia sensory neurons by Palmisano, Ilaria, Danzi, Matt C., Hutson, Thomas H., Zhou, Luming, McLachlan, Eilidh, Serger, Elisabeth, Shkura, Kirill, Srivastava, Prashant K., Hervera, Arnau, Neill, Nick O’, Liu, Tong, Dhrif, Hassen, Wang, Zheng, Kubat, Miroslav, Wuchty, Stefan, Merkenschlager, Matthias, Levi, Liron, Elliott, Evan, Bixby, John L., Lemmon, Vance P., Di Giovanni, Simone

“…Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study…”
Get full text

Genome-wide analysis of differential RNA editing in epilepsy by Srivastava, Prashant Kumar, Bagnati, Marta, Delahaye-Duriez, Andree, Ko, Jeong-Hun, Rotival, Maxime, Langley, Sarah R, Shkura, Kirill, Mazzuferi, Manuela, Danis, Bénédicte, van Eyll, Jonathan, Foerch, Patrik, Behmoaras, Jacques, Kaminski, Rafal M, Petretto, Enrico, Johnson, Michael R

“…The recoding of genetic information through RNA editing contributes to proteomic diversity, but the extent and significance of RNA editing in disease is poorly…”
Get full text

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery by Delahaye-Duriez, Andree, Srivastava, Prashant, Shkura, Kirill, Langley, Sarah R, Laaniste, Liisi, Moreno-Moral, Aida, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Gazina, Elena V, Richards, Kay, Petrou, Steven, Kaminski, Rafal M, Petretto, Enrico, Johnson, Michael R

“…The relationship between monogenic and polygenic forms of epilepsy is poorly understood and the extent to which the genetic and acquired epilepsies share…”
Get full text

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease by Johnson, Michael R, Shkura, Kirill, Langley, Sarah R, Delahaye-Duriez, Andree, Srivastava, Prashant, Hill, W David, Rackham, Owen J L, Davies, Gail, Harris, Sarah E, Moreno-Moral, Aida, Rotival, Maxime, Speed, Doug, Petrovski, Slavé, Katz, Anaïs, Hayward, Caroline, Porteous, David J, Smith, Blair H, Padmanabhan, Sandosh, Hocking, Lynne J, Starr, John M, Liewald, David C, Visconti, Alessia, Falchi, Mario, Bottolo, Leonardo, Rossetti, Tiziana, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Grote, Alexander, Helmstaedter, Christoph, Becker, Albert J, Kaminski, Rafal M, Deary, Ian J, Petretto, Enrico

“…Impairment of cognitive function is a common feature of many neurodevelopmental disorders. Systems genetics analysis in the brain uncovered a convergent gene…”
Get full text

Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers by Palomäki, Antti, Palotie, Aarno, Koskela, Jukka, Eklund, Kari K, Pirinen, Matti, Ripatti, Samuli, Laitinen, Tarja, Mars, Nina

“…To estimate lifetime risk of developing rheumatoid arthritis-associated interstitial lung disease (RA-ILD) with respect to the strongest known risk factor for…”
Get more information

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus by Johnson, Michael R., Behmoaras, Jacques, Bottolo, Leonardo, Krishnan, Michelle L., Pernhorst, Katharina, Santoscoy, Paola L. Meza, Rossetti, Tiziana, Speed, Doug, Srivastava, Prashant K., Chadeau-Hyam, Marc, Hajji, Nabil, Dabrowska, Aleksandra, Rotival, Maxime, Razzaghi, Banafsheh, Kovac, Stjepana, Wanisch, Klaus, Grillo, Federico W., Slaviero, Anna, Langley, Sarah R., Shkura, Kirill, Roncon, Paolo, De, Tisham, Mattheisen, Manuel, Niehusmann, Pitt, O’Brien, Terence J., Petrovski, Slave, von Lehe, Marec, Hoffmann, Per, Eriksson, Johan, Coffey, Alison J., Cichon, Sven, Walker, Matthew, Simonato, Michele, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Schoch, Susanne, De Paola, Vincenzo, Kaminski, Rafal M., Cunliffe, Vincent T., Becker, Albert J., Petretto, Enrico

“…Gene-regulatory network analysis is a powerful approach to elucidate the molecular processes and pathways underlying complex disease. Here we employ systems…”
Get full text

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling by Chen, Huimei, Moreno-Moral, Aida, Pesce, Francesco, Devapragash, Nithya, Mancini, Massimiliano, Heng, Ee Ling, Rotival, Maxime, Srivastava, Prashant K., Harmston, Nathan, Shkura, Kirill, Rackham, Owen J. L., Yu, Wei-Ping, Sun, Xi-Ming, Tee, Nicole Gui Zhen, Tan, Elisabeth Li Sa, Barton, Paul J. R., Felkin, Leanne E., Lara-Pezzi, Enrique, Angelini, Gianni, Beltrami, Cristina, Pravenec, Michal, Schafer, Sebastian, Bottolo, Leonardo, Hubner, Norbert, Emanueli, Costanza, Cook, Stuart A., Petretto, Enrico

“…Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems…”
Get full text

Systems-level analysis of episodic memory performance and neuropsychiatric disease by Shkura, Kirill

“…Episodic memory refers to the ability to store and recall place and time related information. The hippocampus is essential to the encoding of new memories via…”
Get full text

L. Laaniste et al by Laaniste, Liisi, Srivastava, Prashant K, Stylianou, Julianna, Nelofer Syed, Silvia Cases‐Cunillera, Shkura, Kirill, Zeng, Qingyu, Rackham, Owen J L, Langley, Sarah R, Delahaye-Duriez, Andree, O'Neill, Kevin, Williams, Matthew, Becker, Albert, Roncaroli, Federico, Petretto, Enrico, Johnson, Michael R

“…ObjectiveTo identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy…”
Get full text

Les approches de génomique intégrative identifient un réseau de gènes pour le développement de médicaments anti-épileptiques by Delahaye-Duriez, Andrée, Srivastava, Prashant, Shkura, Kirill, Langley, Sarah, Danis, Benedicte, Mazzuferi, Manuela, Foerch, Patrik, Gazina, Elena, Richards, Kay, Petrou, Steven, Kaminski, Rafal, Petretto, Enrico, Johnson, Michael

“…L’épilepsie est une maladie neurologique grave qui se caractérise par une récurrence non provoquée de crises convulsives. La biologie des systèmes et les…”
Get full text