Search Results - "SHISHIDO, Takao"

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents by Hayden, Frederick G, Sugaya, Norio, Hirotsu, Nobuo, Lee, Nelson, de Jong, Menno D, Hurt, Aeron C, Ishida, Tadashi, Sekino, Hisakuni, Yamada, Kota, Portsmouth, Simon, Kawaguchi, Keiko, Shishido, Takao, Arai, Masatsugu, Tsuchiya, Kenji, Uehara, Takeki, Watanabe, Akira

“…In phase 2 and 3 randomized, controlled trials, baloxavir — an inhibitor of influenza cap-dependent endonuclease — showed evidence of clinical symptom relief…”
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In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit by Noshi, Takeshi, Kitano, Mitsutaka, Taniguchi, Keiichi, Yamamoto, Atsuko, Omoto, Shinya, Baba, Keiko, Hashimoto, Takashi, Ishida, Kayo, Kushima, Yukihiro, Hattori, Kazunari, Kawai, Makoto, Yoshida, Ryu, Kobayashi, Masanori, Yoshinaga, Tomokazu, Sato, Akihiko, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Shishido, Takao, Naito, Akira

“…Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical “cap-snatching” step of viral RNA transcription,…”
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Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models by Fukao, Keita, Ando, Yoshinori, Noshi, Takeshi, Kitano, Mitsutaka, Noda, Takahiro, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira

“…Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA…”
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Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model by Nobori, Haruaki, Fukao, Keita, Kuroda, Takayuki, Anan, Naomi, Tashima, Ryoichi, Nakashima, Masaaki, Noda, Sayuri, Tajiri, Minako, Torii, Mikinori, Toba, Shinsuke, Uemura, Kentaro, Sanaki, Takao, Shishido, Takao, Tachibana, Yuki, Kato, Teruhisa

“…OBJECTIVESSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19) and a devastating…”
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Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil by Taniguchi, Keiichi, Ando, Yoshinori, Nobori, Haruaki, Toba, Shinsuke, Noshi, Takeshi, Kobayashi, Masanori, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira, Matsuno, Keita, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi

“…Human infections with avian-origin influenza A(H7N9) virus represent a serious threat to global health; however, treatment options are limited. Here, we show…”
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Inhibition of dengue virus infection by 1‐stearoyl‐2‐arachidonoyl‐phosphatidylinositol in vitro by Sanaki, Takao, Wakabayashi, Masato, Yoshioka, Takeshi, Yoshida, Ryu, Shishido, Takao, Hall, William W., Sawa, Hirofumi, Sato, Akihiko

“…Dengue fever is an acute febrile infectious disease caused by dengue virus (DENV). Despite the significant public health concerns posed by DENV, there are…”
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Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection by Ando, Yoshinori, Noshi, Takeshi, Sato, Kenji, Ishibashi, Toru, Yoshida, Yuki, Hasegawa, Takahiro, Onishi, Motoyasu, Kitano, Mitsutaka, Oka, Ryoko, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira

“…Baloxavir acid, the active form of the orally available prodrug baloxavir marboxil, is a novel cap-dependent endonuclease inhibitor of influenza virus…”
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Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil by Hashimoto, Takashi, Baba, Keiko, Inoue, Kae, Okane, Miyako, Hata, Satoshi, Shishido, Takao, Naito, Akira, Wildum, Steffen, Omoto, Shinya

“…Background Baloxavir marboxil (BXM) is an approved drug that selectively targets cap‐dependent endonuclease on PA subunit in the RNA polymerase complex of…”
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Pharmacokinetic and Pharmacodynamic Analysis of the 3CL Protease Inhibitor Ensitrelvir in a SARS-CoV-2 Infection Mouse Model by Fukao, Keita, Nobori, Haruaki, Kuroda, Takayuki, Baba, Kaoru, Matsumoto, Kazumi, Tanaka, Yukari, Tachibana, Yuki, Kato, Teruhisa, Shishido, Takao

“…The small-molecule antiviral drug ensitrelvir targets the 3C-like protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study…”
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Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses by Fukao, Keita, Noshi, Takeshi, Shano, Shinya, Baba, Kaoru, Sato, Kenji, Sakuramoto, Masashi, Kitade, Naohisa, Tanioka, Hideki, Kusakabe, Shinji, Shishido, Takao

“…Influenza remains a worldwide health concern. Antiviral drugs are considered as one of the useful options for its prevention as a complementary measure to…”
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Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model by Lee, Leo Yy, Zhou, Jie, Koszalka, Paulina, Frise, Rebecca, Farrukee, Rubaiyea, Baba, Keiko, Miah, Shahjahan, Shishido, Takao, Galiano, Monica, Hashimoto, Takashi, Omoto, Shinya, Uehara, Takeki, Mifsud, Edin J, Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Wildum, Steffen, Barclay, Wendy S, Hurt, Aeron C

“…Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses…”
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In Vivo Antiviral Activity of Baloxavir against PA/I38T-Substituted Influenza A Viruses at Clinically Relevant Doses by Kuroda, Takayuki, Fukao, Keita, Yoshida, Shinpei, Oka, Ryoko, Baba, Kaoru, Ando, Yoshinori, Taniguchi, Keiichi, Noshi, Takeshi, Shishido, Takao

“…Although the prevalence of polymerase acidic (PA)/I38T strains of influenza virus with reduced susceptibility to baloxavir acid is low, there is a possibility…”
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Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission by Lee, Leo Yi Yang, Zhou, Jie, Frise, Rebecca, Goldhill, Daniel H, Koszalka, Paulina, Mifsud, Edin J, Baba, Kaoru, Noda, Takahiro, Ando, Yoshinori, Sato, Kenji, Yuki, Aoe-Ishikawa, Shishido, Takao, Uehara, Takeki, Wildum, Steffen, Zwanziger, Elke, Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Hurt, Aeron C, Barclay, Wendy S

“…Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies…”
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Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection by Taniguchi, Keiichi, Ando, Yoshinori, Kobayashi, Masanori, Toba, Shinsuke, Nobori, Haruaki, Sanaki, Takao, Noshi, Takeshi, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira, Matsuno, Keita, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi

“…Human infections caused by the H5 highly pathogenic avian influenza virus (HPAIV) sporadically threaten public health. The susceptibility of HPAIVs to…”
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Kinase Control of Latent HIV-1 Infection: PIM-1 Kinase as a Major Contributor to HIV-1 Reactivation by Duverger, Alexandra, Wolschendorf, Frank, Anderson, Joshua C, Wagner, Frederic, Bosque, Alberto, Shishido, Takao, Jones, Jennifer, Planelles, Vicente, Willey, Christopher, Cron, Randall Q, Kutsch, Olaf

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Kinase Control Prevents HIV-1 Reactivation in Spite of High Levels of Induced NF-κB Activity by WOLSCHENDORF, Frank, BOSQUE, Alberto, SHISHIDO, Takao, DUVERGER, Alexandra, JONES, Jennifer, PLANELLES, Vicente, KUTSCH, Olaf

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Selected Drugs with Reported Secondary Cell-Differentiating Capacity Prime Latent HIV-1 Infection for Reactivation by SHISHIDO, Takao, WOLSCHENDORF, Frank, DUVERGER, Alexandra, WAGNER, Frederic, KAPPES, John, JONES, Jennifer, KUTSCH, Olaf

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The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets by Kitano, Mitsutaka, Matsuzaki, Takanobu, Oka, Ryoko, Baba, Kaoru, Noda, Takahiro, Yoshida, Yuki, Sato, Kenji, Kiyota, Kohei, Mizutare, Tohru, Yoshida, Ryu, Sato, Akihiko, Kamimori, Hiroshi, Shishido, Takao, Naito, Akira

“…Background Baloxavir marboxil (BXM), the oral prodrug of baloxavir acid (BXA), greatly reduces virus titers as well as influenza symptoms of uncomplicated…”
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Corporate Efforts to Research and Develop Therapeutic Agents for Infectious Diseases That Threaten Human by Yoshida, Ryu, Kaki, Rina, Yoshida, Osamu, Shishido, Takao, Kato, Teruhisa, Yamano, Yoshinori

“…Overcoming serious infectious diseases such as malaria, tuberculosis, and other neglected tropical diseases (NTDs) that threaten human life around the world is…”
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Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model by Stannard, Harry L., Mifsud, Edin J., Wildum, Steffen, Brown, Sook Kwan, Koszalka, Paulina, Shishido, Takao, Kojima, Satoshi, Omoto, Shinya, Baba, Keiko, Kuhlbusch, Klaus, Hurt, Aeron C., Barr, Ian G.

“…Influenza antivirals are important tools in our fight against annual influenza epidemics and future influenza pandemics. Combinations of antivirals may reduce…”
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