Search Results - "SHIROTANI, TETSUYA"

Regulation of the Insulin Gene Transcription by Glucose by FURUKAWA, NOBORU, SHIROTANI, TETSUYA, NAKAMARU, KAZUHIKO, MATSUMOTO, KAZUYA, SHICHIRI, MOTOAKI, ARAKI, EIICHI

“…BETA cells in the pancreatic islet synthesize and secrete insulin, the key hormone involved in glucose homeostasis. Impaired insulin secretion and/or impaired…”
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Possible Involvement of Atypical Protein Kinase C (PKC) in Glucose-Sensitive Expression of the Human Insulin Gene: DNA-Binding Activity and Transcriptional Activity of Pancreatic and Duodenal Homeobox Gene-1 (PDX-1) Are Enhanced via Calphostin C-Sensitive but Phorbol 12-Myristate 13-Acetate (PMA) and Gö 6976-Insensitive Pathway by FURUKAWA, NOBORU, SHIROTANI, TETSUYA, ARAKI, EIICHI, KANEKO, KENGO, TODAKA, MIKIO, MATSUMOTO, KAZUYA, TSURUZOE, KAKU, MOTOSHIMA, HIROYUKI, YOSHIZATO, KAZUAKI, KISHIKAWA, HIDEKI, SHICHIRI, MOTOAKI

“…Pancreatic and duodenal homeobox gene-1(PDX-1) is a transcription factor which regulates the insulin gene expression. In this study, we tried to elucidate the…”
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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells by Sakai, Koji, Matsumoto, Kazuya, Nishikawa, Takeshi, Suefuji, Mihoshi, Nakamaru, Kazuhiko, Hirashima, Yoshiaki, Kawashima, Junji, Shirotani, Tetsuya, Ichinose, Kenshi, Brownlee, Michael, Araki, Eiichi

“…Pancreatic β-cells exposed to hyperglycemia produce reactive oxygen species (ROS). Because β-cells are sensitive to oxidative stress, excessive ROS may cause…”
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Possible Involvement of Atypical Protein Kinase C(PKC) in Glucose-Sensitive Expression of the Human Insulin Gene: DNA-Binding Activity and Transcriptional Activity of Pancreatic and Duodenal Homeobox Gene-1(PDX-1) Are Enhanced via Calphostin C-Sensitive but Phorbol 12-Myristate 13-Acetate(PMA) and Goe 6976-Insensitive Pathway by FURUKAWA, NOBORU, SHIROTANI, TETSUYA, ARAKI, EIICHI, KANEKO, KENGO, TODAKA, MIKIO, MATSUMOTO, KAZUYA, TSURUZOE, KAKU, MOTOSHIMA, HIROYUKI, YOSHIZATO, KAZUAKI, KISHIKAWA, HIDEKI, SHICHIRI, MOTOAKI

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Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice by Nishiyama, T, Shirotani, T, Murakami, T, Shimada, F, Todaka, M, Saito, S, Hayashi, H, Noma, Y, Shima, K, Makino, H

“…Defects in the insulin receptor (IR) in diabetic patients have been given much attention. To address the role of such defects, we generated a transgenic (TG)…”
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Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle: Studies in normal and diabetic humans and rats by Taguchi, Tetsuya, Kishikawa, Hideki, Motoshima, Hiroyuki, Sakai, Kohji, Nishiyama, Toshihiko, Yoshizato, Kazuaki, Shirakami, Atsuhisa, Toyonaga, Tetsushi, Shirotani, Tetsuya, Araki, Eiichi, Shichiri, Motoaki

“…Acute exercise induces glucose uptake in skeletal muscle in vivo, but the molecular mechanism of this phenomenon remains to be identified. In this study, we…”
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Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas by TSURUZOE, K, ARAKI, E, MIYAZAKI, J.-I, SHICHIRI, M, FURUKAWA, N, SHIROTANI, T, MATSUMOTO, K, KANEKO, K, MOTOSHIMA, H, YOSHIZATO, K, SHIRAKAMI, A, KISHIKAWA, H

“…Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and…”
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Sudden onset of diabetes with ketoacidosis in a patient treated with FK506/tacrolimus by Toyonaga, Tetsushi, Kondo, Tatsuya, Miyamura, Nobuhiro, Sekigami, Taiji, Sonoda, Kazuhiro, Kodama, Shoko, Shirakami, Atsuhisa, Shirotani, Tetsuya, Araki, Eiichi

“…We report a 43-year-old man who presented diabetic ketoacidosis 1 year after receiving kidney transplantation. He was a recipient of renal transplantation…”
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Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes by MURAKAMI, T, NISHIYAMA, T, SHIROTANI, T, SHINOHARA, Y, KAN, M, ISHII, K, KANAI, F, NAKAZURU, S, EBINA, Y

“…The type 1 glucose transporter (GLUT1) gene encodes an integral membrane glycoprotein responsible for facilitating transfer of glucose across plasma membrane…”
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A carboxy-terminal truncation of human alpha-galactosidase A in a heterozygous female with Fabry disease and modification of the enzymatic activity by the carboxy-terminal domain. Increased, reduced, or absent enzyme activity depending on number of amino acid residues deleted by Miyamura, N, Araki, E, Matsuda, K, Yoshimura, R, Furukawa, N, Tsuruzoe, K, Shirotani, T, Kishikawa, H, Yamaguchi, K, Shichiri, M

“…Fabry disease is an X-linked disorder of glycosphingolipid metabolism caused by a deficiency of alpha-galactosidase A (alpha-Gal A). We identified a novel…”
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Identification of a cis-Acting Element and a Novel trans-Acting Factor of the Human Insulin Receptor Gene in HepG2 and Rat Liver Cells by Yoshizato, Kazuaki, Shirotani, Tetsuya, Furukawa, Noboru, Taguchi, Tetsuya, Motoshima, Hiroyuki, Toyonaga, Tetsushi, Hirashima, Yoshiaki, Kawashima, Junji, Ebina, Yousuke, Shichiri, Motoaki, Araki, Eiichi

“…The liver is a major target organ of insulin and is important for glucose homeostasis. We analyzed the tissue specific regulation of the insulin receptor gene…”
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Thyroxine-Binding Globulin Variant (TBG-Kumamoto): Identification of a Point Mutation and Genotype Analysis of Its Family by SHIROTANI, TETSUYA, KISHIKAWA, HIDEKI, WAKE, NAKAYASU, MIYAMURA, NOBUHIRO, HASHIMOTO, YASUYOSHI, MOTOYOSHI, SADATOSHI, YAMAGUCHI, KOHEI, SHICHIRI, MOTOAKI

“…Thyroxine-binding globulin (TBG) is the major thyroid hormone transport protein. Several inherited TBG variants resulting in partial or complete TBG…”
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Group-II phospholipase A2 enhances oxidized low density lipoprotein-induced macrophage growth through enhancement of GM-CSF release by KANEKO, Kengo, SAKAI, Masakazu, SHICHIRI, Motoaki, MATSUMURA, Takeshi, BIWA, Takeshi, FURUKAWA, Noboru, SHIROTANI, Tetsuya, KIRITOSHI, Shinsuke, ANAMI, Yoshichika, MATSUDA, Kohji, SASAHARA, Takayuki

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Possible Involvement of Atypical Protein Kinase C in Glucose-Induced Expression of the Human Insulin Gene by AKARI, EIICHI, FURUKAWA, NOBORU, SHIROTANI, TETSUYA, MATSUMOTO, KAZUYA, TOYONAGA, TETSUSHI, KISHIKAWA, HIDEKI, SHICHIRI, MOTOAKI

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Bradykinin enhances insulin receptor tyrosine kinase in 32D cells reconstituted with bradykinin and insulin signaling pathways by Motoshima, Hiroyuki, Araki, Eiichi, Nishiyama, Toshihiko, Taguchi, Tetsuya, Kaneko, Kengo, Hirashima, Yoshiaki, Yoshizato, Kazuaki, Shirakami, Atsuhisa, Sakai, Koji, Kawashima, Junji, Shirotani, Tetsuya, Kishikawa, Hideki, Shichiri, Motoaki

“…We have previously shown that bradykinin potentiated insulin-induced glucose uptake through GLUT4 translocation in canine adipocytes and skeletal muscles. The…”
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Group-II phospholipase A 2 enhances oxidized low density lipoprotein-induced macrophage growth through enhancement of GM-CSF release by Kaneko, Kengo, Sakai, Masakazu, Matsumura, Takeshi, Biwa, Takeshi, Furukawa, Noboru, Shirotani, Tetsuya, Kiritoshi, Shinsuke, Anami, Yoshichika, Matsuda, Kohji, Sasahara, Takayuki, Shichiri, Motoaki

“…Inflammatory process plays an important role in the development and progression of atherosclerotic lesions. Recently, group-II phospholipase A 2 (PLA 2), an…”
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A cluster of four Sp1 binding sites required for efficient expression of the human insulin receptor gene by Araki, E, Murakami, T, Shirotani, T, Kanai, F, Shinohara, Y, Shimada, F, Mori, M, Shichiri, M, Ebina, Y

“…Fragments of 5'-flanking sequences of the human insulin receptor gene were analyzed in transient expression assays after transfection of cell lines with…”
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Inhibitory effects of somatostatin analog (SMS 201-995) on pancreatic hormones in patients with malignant islet-cell carcinoma by Fukushima, H, Ueno, S, Sakakida, M, Takahashi, T, Shirotani, T, Araki, E, Kishikawa, H, Yamaguchi, K, Nakamura, N, Uzawa, H

“…Acute effects of somatostatin analog (SMS 201-995) on pancreatic hormones were studied in two patients with malignant islet-cell carcinoma. Before and after…”
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