Search Results - "SHIROTANI, K."

Metabolic Regulation of Brain Aβ by Neprilysin by Iwata, Nobuhisa, Tsubuki, Satoshi, Takaki, Yoshie, Shirotani, Keiro, Lu, Bao, Gerard, Norma P., Gerard, Craig, Hama, Emi, Lee, Hahn-Jun, Saido, Takaomi C.

“…Amyloid β peptide (Aβ), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite in the brain. We examined the role of neprilysin, a…”
Get full text

Lectin-dependent inhibition of antigen-antibody reaction: application for measuring  2,6-sialylated glycoforms of transferrin by Hoshi, K., Kariya, Y., Nara, K., Ito, H., Matsumoto, K., Nagae, M., Yamaguchi, Y., Nakajima, M., Miyajima, M., Arai, H., Kuno, A., Narimatsu, H., Shirotani, K., Hashimoto, Y.

Get full text

Overexpression of Presenilin-2 Enhances Apoptotic Death of Cultured Cortical Neurons by ARAKI, W., YUASA, K., TAKEDA, S., SHIROTANI, K., TAKAHASHI, K., TABIRA, T.

“…: Presenilin‐2 (PS2) is a gene of unknown function linked with some forms of familial Alzheimer's disease. To investigate the biological role of PS2 in…”
Get full text

Effects of carbon source on denitrification efficiency and microbial community structure in a saline wastewater treatment process by Osaka, Toshifumi, Shirotani, Kosuke, Yoshie, Sachiko, Tsuneda, Satoshi

“…Two different denitrifying reactors were monitored in order to evaluate the effects of carbon source on denitrification efficiency and microbial community…”
Get full text

Clearance of Extracellular and Cell-Associated Amyloid   Peptide through Viral Expression of Neprilysin in Primary Neurons by Hama, E., Shirotani, K., Masumoto, H., Sekine-Aizawa, Y., Aizawa, H., Saido, T. C.

Get full text

Purification of Nuclear Proteins That Potentially Regulate Transcription of the MUC1 Mucin Gene Induced by a Soluble Factor by Shirotani, Keiro, Irimura, Tatsuro

“…Transcriptional regulation of the MUC1 mucin gene in KM12C human colon carcinoma cells, which is induced by a soluble stimulatory factor derived from normal…”
Get full text

Identification of distinct gamma-secretase complexes with different APH-1 variants by Shirotani, Keiro, Edbauer, Dieter, Prokop, Stefan, Haass, Christian, Steiner, Harald

“…The gamma-secretase complex catalyzes the final intramembraneous cleavage of the beta-amyloid precursor protein, liberating the neurotoxic amyloid beta-peptide…”
Get full text

Transcriptional regulation of the MUC1 mucin gene in colon carcinoma cells by a soluble factor. Identification of a regulatory element by SHIROTANI, K, TAYLOR-PAPADIMITRIOU, J, GENDLER, S. J, IRIMURA, T

“…We have investigated a mechanism of the regulation of mucin core polypeptide (MUC1) gene expression, which is induced by a soluble stimulatory factor, in KM12C…”
Get full text

Vortex structures and temperature fluctuations in a bluff-body burner by Nishimura, T., Kaga, T., Shirotani, K., Kadowaki, J.

Get full text

Requirement of PEN-2 for Stabilization of the Presenilin N-/C-terminal Fragment Heterodimer within the γ-Secretase Complex by Prokop, Stefan, Shirotani, Keiro, Edbauer, Dieter, Haass, Christian, Steiner, Harald

“…γ-Secretase is a protease complex composed of presenilin (PS), nicastrin (NCT), APH-1, and PEN-2, which catalyzes intramembrane cleavage of several type I…”
Get full text

Biochemical Identification of the Neutral Endopeptidase Family Member Responsible for the Catabolism of Amyloid   Peptide in the Brain by Takaki, Y., Iwata, N., Tsubuki, S., Taniguchi, S., Toyoshima, S., Lu, B., Gerard, N. P., Gerard, C., Lee, H.-J., Shirotani, K., Saido, T. C.

Get full text

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain by Iwata, Nobuhisa, Mizukami, Hiroaki, Shirotani, Keiro, Takaki, Yoshie, Muramatsu, Shin-ichi, Lu, Bao, Gerard, Norma P, Gerard, Craig, Ozawa, Keiya, Saido, Takaomi C

“…A local increase in amyloid-beta peptide (Abeta) is closely associated with synaptic dysfunction in the brain in Alzheimer's disease. Here, we report on the…”
Get full text

Distinct Mechanistic Roles of Calpain and Caspase Activation in Neurodegeneration as Revealed in Mice Overexpressing Their Specific Inhibitors by Higuchi, Makoto, Tomioka, Masanori, Takano, Jiro, Shirotani, Keiro, Iwata, Nobuhisa, Masumoto, Hajime, Maki, Masatoshi, Itohara, Shigeyoshi, Saido, Takaomi C.

“…Enzymatic proteolysis has been implicated in diverse neuropathological conditions, including acute/subacute ischemic brain injuries and chronic…”
Get full text

Alzheimer's β-Secretase, β-Site Amyloid Precursor Protein-Cleaving Enzyme, is Responsible for Cleavage Secretion of a Golgi-Resident Sialyltransferase by Kitazume, Shinobu, Tachida, Yuriko, Oka, Ritsuko, Shirotani, Keiro, Saido, Takaomi C., Hashimoto, Yasuhiro

“…The deposition of amyloid β-peptide (Aβ) in the brain is closely associated with the development of Alzheimer's disease. Aβ is generated from the amyloid…”
Get full text

Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases by Shirotani, Keiro, Tsubuki, Satoshi, Iwata, Nobuhisa, Takaki, Yoshie, Harigaya, Wakako, Maruyama, Kei, Kiryu-Seo, Sumiko, Kiyama, Hiroshi, Iwata, Hiroshi, Tomita, Taisuke, Iwatsubo, Takeshi, Saido, Takaomi C.

“…To identify the amyloid β peptide (Aβ) 1–42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin…”
Get full text

γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin by Shirotani, Keiro, Edbauer, Dieter, Capell, Anja, Schmitz, Julia, Steiner, Harald, Haass, Christian

“…γ-Secretase is a high molecular weight multicomponent protein complex with an unusual intramembrane-cleaving aspartyl protease activity. γ-Secretase is…”
Get full text

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation by Tabira, Takeshi, Chui, De-Hua, Tanahashi, Hiroshi, Ozawa, Kazuharu, Ikeda, Sachiya, Checler, Frédéric, Ueda, Otoya, Suzuki, Hiroshi, Araki, Wataru, Inoue, Haruhisa, Shirotani, Keiro, Takahashi, Keikichi, Gallyas, Ferenc

“…Familial Alzheimer disease mutations of presenilin 1 (PS-1) enhance the generation of A beta1-42, indicating that PS-1 is involved in amyloidogenesis. However,…”
Get full text

Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1 by Shirotani, Keiro, Edbauer, Dieter, Kostka, Marcus, Steiner, Harald, Haass, Christian

“…γ‐Secretase is a high molecular mass aspartyl protease complex composed of presenilin (PS1 or PS2), nicastrin (Nct), anterior pharynx‐defective‐1 (APH‐1) and…”
Get full text

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons by Hama, Emi, Shirotani, Keiro, Iwata, Nobuhisa, Saido, Takaomi C

“…Neprilysin (NEP) is a rate-limiting amyloid beta peptide (Abeta)-degrading enzyme in the brain. We demonstrated previously that overexpression of neprilysin in…”
Get full text

Nicastrin Interacts with γ-Secretase Complex Components via the N-terminal Part of Its Transmembrane Domain by Capell, Anja, Kaether, Christoph, Edbauer, Dieter, Shirotani, Keiro, Merkl, Sabine, Steiner, Harald, Haass, Christian

“…Two secretases are involved in the generation of amyloid β-peptide, the principal component of amyloid plaques in the brains of Alzheimer's disease patients…”
Get full text