Search Results - "SHIRLEY, J. T"

Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues:  Implications for a New Active Site Model of PDE4 by Kleinman, Edward F, Campbell, Erin, Giordano, Lisa A, Cohan, Victoria L, Jenkinson, Teresa H, Cheng, John B, Shirley, John T, Pettipher, E. Roy, Salter, Eben D, Hibbs, Tessa A, DiCapua, Frank M, Bordner, John

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Biarylcarboxylic Acids and -amides:  Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret by Duplantier, Allen J, Biggers, Michael S, Chambers, Robert J, Cheng, John B, Cooper, Kelvin, Damon, David B, Eggler, James F, Kraus, Kenneth G, Marfat, Anthony, Masamune, Hiroko, Pillar, Joann S, Shirley, John T, Umland, John P, Watson, John W

“…In addition to having desirable inhibitory effects on inflammation, anaphylaxis, and smooth muscle contraction, PDE-IV inhibitors also produce undesirable side…”
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Discovery of CP-199,330 and CP-199,331 : Two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity by CHAMBERS, R. J, MARFAT, A, WATSON, J. W, ANTOGNOLI, G. W, CHENG, J. B, DAMON, D. B, KUPERMAN, A. V, LISTON, T. C, MEBUS, C, PILLAR, J. S, SHIRLEY, J. T

“…CP-199,330 (3) and CP-199,331 (4) are cysLT1 receptor antagonists that are equipotent to marketed cysLT1 receptor antagonists zafirlukast and pranlukast, show…”
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Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists by CHAMBERS, R. J, ANTOGNOLI, G. W, CHENG, J. B, KUPERMAN, A. V, LISTON, T. C, MARFAT, A, OWENS, B. S, PILLAR, J. S, SHIRLEY, J. T, WATSON, J. W

“…A new series of cysLT1 receptor antagonists represented by CP-288,886 (7) and CP-265,298 (8) were developed which are equipotent to clinical cysLT1 receptor…”
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Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid by Cheng, J B, Pillar, J S, Shirley, J T, Showell, H J, Watson, J W, Cohan, V L

“…Eosinophil peroxidase (EPO) has been used previously to detect the number of eosinophils in the peritoneal exudate and bone marrow of mice. The present study…”
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Development of new chromanol antagonists of leukotriene D4 by CHAMBERS, R. J, ANTOGNOLI, G. W, CHENG, J. B, MARFAT, A, PILLAR, J. S, SHIRLEY, J. T, WATSON, J. W

“…By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical…”
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Competition of leukotrienes and ICI-198,615 for [3H]LTD4 binding sites in guinea pig lung membranes suggests the involvement of two LTD4 receptor subtypes by Shirley, J T, Cheng, J B

“…Pharmacological analysis of the effects of leukotriene D4 (LTD4) antagonists on contraction of guinea pig airway smooth muscle to leukotrienes reveals the…”
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Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs by Cheng, J B, Pillar, J S, Conklyn, M J, Breslow, R, Shirley, J T, Showell, H J

“…Lungs from guinea pigs passively sensitized with an affinity-purified IgG1 antibody produce both leukotriene (LT)D4 and thromboxane (Tx)B2 upon ex vivo antigen…”
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N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D4 by BROWN, M. F, MARFAT, A, PILLAR, J. S, SHIRLEY, J. T, WATSON, J. W, ANTOGNOLI, G, CHAMBERS, R. J, CHENG, J. B, DAMON, D. B, LISTON, T. E, MCGLYNN, M. A, O'SULLIVAN, S. P, OWENS, B. S

“…Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed…”
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Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase by Lowe, John A, Archer, Robert L, Chapin, Douglas S, Cheng, John B, Helweg, David, Johnson, Jonathan L, Koe, B. Kenneth, Lebel, Lorraine A, Moore, Peter F

“…A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase…”
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Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α by Chambers, R.J., Marfat, A., Cheng, J.B., Cohan, V.L., Damon, D.B., Duplantier, A.J., Hibbs, T.A., Jenkinson, T.H., Johnson, K.L., Kraus, K.G., Pettipher, E.R., Salter, E.D., Shirley, J.T., Umland, J.P.

“…Tumor necrosis factor-α (TNF-α) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV)…”
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A Preview of Augmented Reality as Pioneering Method in Education by Shirley, J.T. Preethy, Malathi, S.

“…In Today's fast paced world, constant changes occur in everything around us especially technologies and this triggers the education sector to embrace the…”
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Antigen-dependent leukotriene synthesis and histamine release from IgG1 passively-sensitized guinea pig lungs ex vivo: relationship between serum levels of antigen-specific IgG1 and mediator synthesis/release by Cheng, J B, Pillar, J S, Conklyn, M J, Breslow, R, Shirley, J T, Gerard, N P, Showell, H J

“…Naive guinea-pigs were passively sensitized with varying amounts of affinity column purified, homologous, anti-ovalbumin IgG1 (anti-OA IgG1) and then examined…”
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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function by Chambers, Robert J., Abrams, Kristin, Castleberry, Tessa A., Cheng, John B., Fisher, Douglas A., Kamath, Ajith V., Marfat, Anthony, Nettleton, David O., Pillar, Joann D., Salter, Eben D., Sheils, Alissa L., Shirley, John T., Turner, Claudia R., Umland, John P., Lam, Kelvin T.

“…Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis…”
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Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonists by Masamune, H., Breslow, R., Cheng, J.B., Conklyn, M.J., Eggler, J.F., Marfat, A., Melvin, L.S., Pillar, J.S., Shirley, J.T., Showell, H.J., Tickner, J.E.

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Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists by Andrews, E.G., Antognoli, G.W., Breslow, R., Carta, M.P., Carty, T.J., Chambers, R.J., Cheng, J.B., Cohan, V.L., Collins, J.L., Damon, D.B., Delehunt, J., Eggler, J.F., Eskra, J.D., Freiert, K.W., Hada, W.A., Marfat, A., Masamune, H., Melvin, L.S., Mularski, C.J., Naclerio, B.A., Pazoles, C.J., Pillar, J.S., Rappach, L.A., Reiche, P., Rusek, F.W., Sherman, H., Shirley, J.T., Sweeney, F.J., Tickner, J.E., Watson, J.W., Wright, C.F.

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Development of new chromanol antagonists of leukotriene D 4 by Chambers, R.J., Antognoli, G.W., Cheng, J.B., Marfat, A., Pillar, J.S., Shirley, J.T., Watson, J.W.

“…By addressing the issues of potency and metabolism in 3, a new series of LTD 4 antagonists represented by (+)- 26 was developed which is equipotent to clinical…”
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Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [ 3H]rolipram binding site by Cheng, John B., Cooper, Kelvin, Duplantier, Allen J., Eggler, James F., Kraus, Kenneth G., Marshall, Sally C., Marfat, Anthony, Masamune, Hiroko, Shirley, John T., Tickner, Jeenene E., Umland, John P.

“…The synthesis and biological properties of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors are described. These catechol…”
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N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D 4 by Brown, Matthew F., Marfat, Anthony, Antognoli, Gerard, Chambers, Robert J., Cheng, John B., Damon, David B., Liston, Theodore E., McGlynn, Molly A., O'Sullivan, Stacie P., Owens, Brian S., Pillar, Joann S., Shirley, John T., Watson, John W.

“…Exploration of the indole nitrogen region of Zafirlukast ( 1) has uncovered a potent series of cysteinyl leukotriene D 4 (LTD 4) antagonists. These studies…”
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National Shakespeare Committee by TAYLOR. MARTIN. BROOKS. BREWER. HARDY, TOM THEODORE SHIRLEY J. T, WALKER. BELL. L.GRUNEISEN. FRISWELL, THOMAS ROBERT C. HAIN

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