Search Results - "SHIRATO, K"

Thrombin stimulates production of fibronectin by human proximal tubular epithelial cells via a transforming growth factor- -dependent mechanism by Shirato, K.

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Novel Roles of CpG Oligodeoxynucleotides as a Leader for the Sampling and Presentation of CpG-Tagged Antigen by Dendritic Cells by Shirota, Hidekazu, Sano, Kunio, Hirasawa, Noriyasu, Terui, Tadashi, Ohuchi, Kazuo, Hattori, Toshio, Shirato, Kunio, Tamura, Gen

“…Oligodeoxynucleotides containing CpG motifs have been highlighted as potent Th1 activators. We previously reported that Ag and CpG, when conjugated together,…”
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Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma by Kikuchi, Yoshihiro, Okabe, Shinichi, Tamura, Gen, Hida, Wataru, Homma, Masaaki, Shirato, Kunio, Takishima, Tamotsu

“…Concern about deaths from asthma is increasing 1 – 3 . Most of the deaths are avoidable if patients are adequately treated 3 , 4 . However, adequate treatment…”
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Gramicidin-perforated patch recording: GABA response in mammalian neurones with intact intracellular chloride by Ebihara, S, Shirato, K, Harata, N, Akaike, N

“…1. By the development of a new perforated patch method using gramicidin, the effects of GABA on neurones dissociated from the rat substantia nigra pars…”
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Activation and Transforming Growth Factor-beta Production in Eosinophils by Hyaluronan by Ohkawara, Yuichi, Tamura, Gen, Iwasaki, Tadashi, Tanaka, Akiko, Kikuchi, Tadashi, Shirato, Kunio

“…To investigate whether extracellular matrix glycosaminoglycan hyaluronan (HA) modulates eosinophil activation and transforming growth factor (TGF)-beta…”
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Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma by Shimura, S, Andoh, Y, Haraguchi, M, Shirato, K

“…The aim of this study was to elucidate the mechanism of the formation of the widespread mucous-plugging observed in autopsied lungs from patients with…”
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Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways by Ichinose, M, Sugiura, H, Yamagata, S, Koarai, A, Tomaki, M, Ogawa, H, Komaki, Y, Barnes, P.J, Shirato, K, Hattori, T

“…Reactive nitrogen species (RNS) have been reported to be involved in the inflammatory process in chronic obstructive pulmonary disease (COPD). However, there…”
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Correlation between change in pulmonary function and suppression of reactive nitrogen species production following steroid treatment in COPD by Sugiura, H, Ichinose, M, Yamagata, S, Koarai, A, Shirato, K, Hattori, T

“…Background: Reactive nitrogen species (RNS) have a number of inflammatory actions and the production of these molecules has been reported to be increased in…”
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Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation by Ohno, I, Ohtani, H, Nitta, Y, Suzuki, J, Hoshi, H, Honma, M, Isoyama, S, Tanno, Y, Tamura, G, Yamauchi, K, Nagura, H, Shirato, K

“…Bronchial asthma is characterized by eosinophil infiltration and tissue remodeling. Matrix metalloproteinases (MMPs) are thought to play critical roles by…”
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iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response by Koarai, A, Ichinose, M, Sugiura, H, Tomaki, M, Watanabe, M, Yamagata, S, Komaki, Y, Shirato, K, Hattori, T

“…Nitric oxide (NO) shows proinflammatory actions mainly via reactive nitrogen species (RNS) formation through superoxide- and peroxidase-dependent mechanisms…”
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Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation by Ohno, I, Nitta, Y, Yamauchi, K, Hoshi, H, Honma, M, Woolley, K, O'Byrne, P, Tamura, G, Jordana, M, Shirato, K

“…The increase in thickness of bronchial walls by such structural changes as subepithelial fibrosis contributes to the severity and chronicity of asthma by…”
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Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats by Minatoya, Y., Ito, K., Kagaya, Y., Asaumi, Y., Takeda, M., Nakayama, M., Takahashi, J., Iguchi, A., Shirato, K., Shimokawa, H.

“…Aim:  Chronic cardiac unloading causes a time‐dependent upregulation of phospholamban (PLB) and depression of myocyte contractility in normal rat hearts. As…”
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Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia by Ogawa, H, Mizusawa, A, Kikuchi, Y, Hida, W, Miki, H, Shirato, K

“…1. We examined the role of nitric oxide (NO) in respiratory regulation in the nucleus tractus solitarii (NTS), where L-glutamate release associated with…”
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In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia by Mizusawa, A, Ogawa, H, Kikuchi, Y, Hida, W, Kurosawa, H, Okabe, S, Takishima, T, Shirato, K

“…1. An attempt has been made to test the hypothesis that, in the caudal part of nucleus tractus solitarii (NTS) where carotid sinus nerve (CSN) afferents…”
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Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibre by Ichinose, M, Takahashi, T, Sugiura, H, Endoh, N, Miura, M, Mashito, Y, Shirato, K

“…Airway hyperresponsiveness (AHR), in which airway inflammation has been reported to be a key factor, is an important component of asthma. However the precise…”
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Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus by Mizutani, T, Kobayashi, M, Eshita, Y, Shirato, K, Kimura, T, Ako, Y, Miyoshi, H, Takasaki, T, Kurane, I, Kariwa, H

“…We recently cloned a c-Jun amino-terminal kinase (JNK) sequence from the C6/36 cell line, derived from the mosquito Aedes albopictus. We showed that SP600125,…”
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Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats by Tabata, M, Kurosawa, H, Kikuchi, Y, Hida, W, Ogawa, H, Okabe, S, Tun, Y, Hattori, T, Shirato, K

“…The purpose of this study was to examine our hypothesis that gamma-aminobutyric acid (GABA) in the nucleus tractus solitarii (NTS) may be related to the…”
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TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia by Haneda, K, Sano, K, Tamura, G, Sato, T, Habu, S, Shirato, K

“…Induction of peripheral tolerance is one of the feasible approaches for the control of autoimmunities and allergies. Therapeutic applications of oral tolerance…”
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Effects of Pimobendan on Adverse Cardiac Events and Physical Activities in Patients With Mild to Moderate Chronic Heart Failure: The Effects of Pimobendan on Chronic Heart Failure Study (EPOCH Study) by Group, The EPOCH Study

“…The long-term beneficial effects of pimobendan in the treatment of chronic heart failure (CHF) have not been established, so the present trial compared…”
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A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients by Ichinose, M, Miura, M, Yamauchi, H, Kageyama, N, Tomaki, M, Oyake, T, Ohuchi, Y, Hida, W, Miki, H, Tamura, G, Shirato, K

“…Recent reports suggest the involvement of vascular phenomena in exercise-induced asthma. Sensory neuropeptides, such as substance P (SP), which causes airway…”
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