Search Results - "SHIRASAKA, Yoshiyuki"

Food effects on gastrointestinal physiology and drug absorption by Kambayashi, Atsushi, Shirasaka, Yoshiyuki

“…Food ingestion affects the oral absorption of many drugs in humans. In this review article, we summarize the physiological factors in the gastrointestinal (GI)…”
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Food effects on oral drug absorption: Recent advances in understanding mechanisms and quantitative prediction by Shirasaka, Yoshiyuki, Kambayashi, Atsushi

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Magnitude of Fruit Juice–Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices by Takemura, Miyuki, Inoue, Katsuhisa, Tamai, Ikumi, Shirasaka, Yoshiyuki

“…We recently reported that the gastrointestinal (GI) fluid volume is influenced by the solution osmolality, and proposed that this effect may play a role in…”
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Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme by Suzuki, Satoru, Inoue, Katsuhisa, Tamai, Ikumi, Shirasaka, Yoshiyuki

“…Purpose This study aims to understand the effect of salvage enzyme activity on the saturable kinetics of facilitated cellular uptake of purine nucleobase by…”
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Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model by Suzuki, Satoru, Inoue, Katsuhisa, Tamai, Ikumi, Shirasaka, Yoshiyuki

“…Since the processes of dissolution and membrane permeation are affected by the water content in the gastrointestinal (GI) tract, the water dynamics in the GI…”
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Evaluation of biliary excretion process of drugs and bile acids using permeation assay by a novel in vitro hepatocyte culture system (ICHEP) by Arakawa, Hiroshi, Nakazono, Yuya, Shirasaka, Yoshiyuki, Tamai, Ikumi

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Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins by Yin, Jia, Duan, Haichuan, Shirasaka, Yoshiyuki, Prasad, Bhagwat, Wang, Joanne

“…Atenolol is a β-blocker widely used in the treatment of hypertension. Atenolol is cleared predominantly by the kidney by both glomerular filtration and active…”
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Evaluation of Platinum Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue Slices by Using Gas-Permeable Plates by Arakawa, Hiroshi, Nagao, Yurika, Nedachi, Shiho, Shirasaka, Yoshiyuki, Tamai, Ikumi

“…The type of method adopted for the evaluation of drug-induced kidney injury (DIKI) plays an important role during the drug discovery process. In the present…”
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Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats by Funai, Yuta, Ichijo, Kazuki, Suzuki, Satoru, Tateishi, Yuta, Inoue, Katsuhisa, Tamai, Ikumi, Shirasaka, Yoshiyuki

“…The drug absorption profile is dependent on the luminal drug concentration, which in turn is influenced by the gastrointestinal (GI) fluid dynamics. In the…”
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Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening by Kadoguchi, Moeno, Arakawa, Hiroshi, Honda, Ryokichi, Hotta, Kazuki, Shirasaka, Yoshiyuki, Deguchi, Yoshiharu, Tamai, Ikumi

“…Aim Identification of blood-brain barrier (BBB) uptake transporters is a major challenge in the research and development of central nervous system (CNS) drugs…”
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Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter by Takahashi, Masaki, Kishimoto, Hisanao, Shirasaka, Yoshiyuki, Inoue, Katsuhisa

“…SLC16A12/MCT12 has been recently identified as a creatine transporter in a Xenopus oocyte expression system; however, the mechanism, by which MCT12 transports…”
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Functional identification of soluble uric acid as an endogenous inhibitor of CD38 by Wen, Shijie, Arakawa, Hiroshi, Yokoyama, Shigeru, Shirasaka, Yoshiyuki, Higashida, Haruhiro, Tamai, Ikumi

“…Excessive elevation or reduction of soluble uric acid (sUA) levels has been linked to some of pathological states, raising another subject that sUA at…”
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Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine by Miyazaki, Kaori, Kishimoto, Hisanao, Muratani, Miho, Kobayashi, Hanai, Shirasaka, Yoshiyuki, Inoue, Katsuhisa

“…Purpose Mucins are the principal glycoproteins in mucus and have been implicated in the limitation of intestinal drug absorption; however, the contribution of…”
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Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats by Funai, Yuta, Shirasaka, Yoshiyuki, Ishihara, Marika, Takemura, Miyuki, Ichijo, Kazuki, Kishimoto, Hisanao, Inoue, Katsuhisa

“…A recent clinical study reported that the ingestion of apple juice (AJ) markedly reduced the plasma concentration of atenolol; however, our in vitro study…”
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Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT by Zhu, Qiunan, Iwai, Ryusuke, Okaguchi, Takehiro, Shirasaka, Yoshiyuki, Tamai, Ikumi

“…Apples are known to exhibit various beneficial effects on human health. In the present study, we investigated the effect of continuous intake of apple juice…”
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Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein by Shirasaka, Yoshiyuki, Suzuki, Kensuke, Nakanishi, Takeo, Tamai, Ikumi

“…The purpose of this study is to examine the contributions of organic anion transporting polypeptide (Oatp) and/or P-glycoprotein (P-gp) to grapefruit juice…”
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Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics by Shirasaka, Yoshiyuki, Seki, Maria, Hatakeyama, Marie, Kurokawa, Yuko, Uchiyama, Hiroki, Takemura, Miyuki, Yasugi, Yugo, Kishimoto, Hisanao, Tamai, Ikumi, Wang, Joanne, Inoue, Katsuhisa

“…The aim of this study was to investigate the contributions of multiple transport mechanisms to the intestinal absorption of metformin, focusing on OCT3, PMAT,…”
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Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide by Shirasaka, Yoshiyuki, Suzuki, Kensuke, Nakanishi, Takeo, Tamai, Ikumi

“…Purpose The purpose of this study is to clarify the impact of organic anion transporting polypeptide (Oatp) on intestinal absorption of the HMG-CoA reductase…”
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Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine by Kishimoto, Hisanao, Miyazaki, Kaori, Tedzuka, Hiroshi, Ozawa, Ryosuke, Kobayashi, Hanai, Shirasaka, Yoshiyuki, Inoue, Katsuhisa

“…As advanced synthetic technology has enabled drug candidate development with complex structure, resulting in low solubility and membrane permeability, the…”
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Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites by Shirasaka, Yoshiyuki, Mori, Takanori, Shichiri, Megumi, Nakanishi, Takeo, Tamai, Ikumi

“…The purpose of this study was to examine whether the presence of multiple binding sites can explain the pleiotropy of substrate recognition by OATP2B1, using…”
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