Search Results - "SHIPSTON, Michael J"

Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels by Tian, Lijun, McClafferty, Heather, Knaus, Hans-Guenther, Ruth, Peter, Shipston, Michael J.

“…Protein palmitoylation is rapidly emerging as an important determinant in the regulation of ion channels, including large conductance calcium-activated…”
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Substrate recognition by the cell surface palmitoyl transferase DHHC5 by Howie, Jacqueline, Reilly, Louise, Fraser, Niall J., Walker, Julia M. Vlachaki, Wypijewski, Krzysztof J., Ashford, Michael L. J., Calaghan, Sarah C., McClafferty, Heather, Tian, Lijun, Shipston, Michael J., Boguslavskyi, Andrii, Shattock, Michael J., Fuller, William

“…The cardiac phosphoprotein phospholemman (PLM) regulates the cardiac sodium pump, activating the pump when phosphorylated and inhibiting it when palmitoylated…”
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Sex differences in pituitary corticotroph excitability by Duncan, Peter J, Romanò, Nicola, Nair, Sooraj V, Murray, Joanne F, Le Tissier, Paul, Shipston, Michael J

“…Stress-related illness represents a major burden on health and society. Sex differences in stress-related disorders are well documented, with women having…”
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Regulation of large conductance calcium- and voltage-activated potassium (BK) channels by S-palmitoylation by Shipston, Michael J

“…BK (large conductance calcium- and voltage-activated potassium) channels are important determinants of physiological control in the nervous, endocrine and…”
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Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs by Duncan, Peter J, Tabak, Joël, Ruth, Peter, Bertram, Richard, Shipston, Michael J

“…Corticotroph cells from the anterior pituitary are an integral component of the hypothalamic-pituitary-adrenal (HPA) axis, which governs the neuroendocrine…”
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Multiple Palmitoyltransferases Are Required for Palmitoylation-dependent Regulation of Large Conductance Calcium- and Voltage-activated Potassium Channels by Tian, Lijun, McClafferty, Heather, Jeffries, Owen, Shipston, Michael J.

“…Palmitoylation is emerging as an important and dynamic regulator of ion channel function; however, the specificity with which the large family of acyl…”
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Regulatory effects of protein S-acylation on insulin secretion and insulin action by Chamberlain, Luke H, Shipston, Michael J, Gould, Gwyn W

“…Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of…”
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Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C by Zhou, Xiaobo, Wulfsen, Iris, Korth, Michael, McClafferty, Heather, Lukowski, Robert, Shipston, Michael J., Ruth, Peter, Dobrev, Dobromir, Wieland, Thomas

“…Large-conductance, calcium- and voltage-gated potassium (BK) channels play an important role in cellular excitability by controlling membrane potential and…”
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Large conductance Ca2+‐activated K+ (BK) channels promote secretagogue‐induced transition from spiking to bursting in murine anterior pituitary corticotrophs by Duncan, Peter J., Şengül, Sevgi, Tabak, Joël, Ruth, Peter, Bertram, Richard, Shipston, Michael J.

“…Key points Corticotroph cells of the anterior pituitary are electrically excitable and are an integral component of the hypothalamic‐pituitary‐adrenal axis…”
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S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels by Shipston, Michael J

“…Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK) channels are important determinants of their…”
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The physiology of protein S-acylation by Chamberlain, Luke H, Shipston, Michael J

“…Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the…”
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Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels by Tian, Lijun, Jeffries, Owen, McClafferty, Heather, Molyvdas, Adam, Rowe, Iain C.M, Saleem, Fozia, Chen, Lie, Greaves, Jennifer, Chamberlain, Luke H, Knaus, Hans-Guenther, Ruth, Peter, Shipston, Michael J

“…Large conductance calcium- and voltage-gated potassium (BK) channels are important regulators of physiological homeostasis and their function is potently…”
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An Electrostatic Switch Controls Palmitoylation of the Large Conductance Voltage- and Calcium-activated Potassium (BK) Channel by Jeffries, Owen, Tian, Lijun, McClafferty, Heather, Shipston, Michael J.

“…Protein palmitoylation is a major dynamic posttranslational regulator of protein function. However, mechanisms that control palmitoylation are poorly…”
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Ion Channel Regulation by Protein Palmitoylation by Shipston, Michael J.

“…Protein S-palmitoylation, the reversible thioester linkage of a 16-carbon palmitate lipid to an intracellular cysteine residue, is rapidly emerging as a…”
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Hierarchal type III secretion of translocators and effectors from Escherichia coli O157:H7 requires the carboxy terminus of SepL that binds to Tir by Wang, Dai, Roe, Andrew J, McAteer, Sean, Shipston, Michael.J, Gally, David L

“…Type III secretion (T3S) from enteric bacteria is a co-ordinated process with a hierarchy of secreted proteins. In enteropathogenic and enterohaemorrhagic…”
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LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response by MacMillan, Sandy, Holmes, Andrew P., Dallas, Mark L., Mahmoud, Amira D., Shipston, Michael J., Peers, Chris, Hardie, D. Grahame, Kumar, Prem, Evans, A. Mark

“…The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to the body and is primarily mediated by the carotid bodies. Here we…”
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Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage- and Calcium-activated Potassium (BK) Channels by Jeffries, Owen, Geiger, Nina, Rowe, Iain C.M., Tian, Lijun, McClafferty, Heather, Chen, Lie, Bi, Danlei, Knaus, Hans Guenther, Ruth, Peter, Shipston, Michael J.

“…S-Palmitoylation is rapidly emerging as an important post-translational mechanism to regulate ion channels. We have previously demonstrated that large…”
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Publisher Correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response by MacMillan, Sandy, Holmes, Andrew P., Dallas, Mark L., Mahmoud, Amira D., Shipston, Michael J., Peers, Chris, Hardie, D. Grahame, Kumar, Prem, Evans, A. Mark

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Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice by SAUSBIER, Matthias, AMTZ, Claudia, ABDULLAH, Usamah, KRIPPEIT-DREWS, Peter, FEIL, Robert, HOFMANN, Franz, KNAUS, Hans-Günier, KENYON, Chris, SHIPSTON, Michael J, STORM, Johan F, NEUHUBER, Winfried, KORTH, Michael, BUCURENCIU, Iancu, SCHUBERT, Rudolf, GOLLASCH, Maik, RUTH, Peter, HONG ZHAO, ZHOU, Xiao-Bo, SAUSBIER, Ulrike, FEIL, Susanne, KAMM, Simone, ESSIN, Kyrill, SAILER, Claudia A

“…Abnormally elevated blood pressure is the most prevalent risk factor for cardiovascular disease. The large-conductance, voltage- and Ca2+-dependent K+ (BK)…”
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Ion channel regulation by protein S-acylation by Shipston, Michael J

“…Protein S-acylation, the reversible covalent fatty-acid modification of cysteine residues, has emerged as a dynamic posttranslational modification (PTM) that…”
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