Search Results - "SHIOVITZ, Thomas"

Mitigating the Effects of Nonadherence in Clinical Trials by Shiovitz, Thomas M., Bain, Earle E., McCann, David J., Skolnick, Phil, Laughren, Thomas, Hanina, Adam, Burch, Daniel

“…Accounting for subject nonadherence and eliminating inappropriate subjects in clinical trials are critical elements of a successful study. Nonadherence can…”
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A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition by HARRIGAN, Edmund P, MICELI, Jeffrey J, ANZIANO, Richard, WATSKY, Eric, REEVES, Karen R, CUTLER, Neal R, SRAMEK, T. John, SHIOVITZ, Thomas, MIDDLE, Michelle

“…Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The…”
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Atomoxetine Augmentation of Cholinesterase Inhibitor Therapy in Patients With Alzheimer Disease: 6-Month, Randomized, Double-Blind, Placebo-Controlled, Parallel-Trial Study by Mohs, Richard C., Ph.D, Shiovitz, Thomas M., M.D, Tariot, Pierre N., M.D, Porsteinsson, Anton P., M.D, Baker, Kurt D., M.S, Feldman, Peter D., Ph.D

“…Objectives: To examine the efficacy and tolerability of atomoxetine (ATX) in improving cognitive performance of patients with Alzheimer dementia. Design: A…”
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Do Professional Subjects Retire? by Shiovitz, Thomas M., MD, Schoneberg, Sabrina H., BA, Safran, Rachel O., BA

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Adjunctive therapy with pregabalin in generalized anxiety disorder patients with partial response to SSRI or SNRI treatment by Rickels, Karl, Shiovitz, Thomas M, Ramey, Tanya S, Weaver, Jerry J, Knapp, Lloyd E, Miceli, Jeffrey J

“…This study evaluated the efficacy of adjunctive pregabalin versus placebo for treatment of patients with generalized anxiety disorder (GAD) who had not…”
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Failure rate and "professional subjects" in clinical trials of major depressive disorder by Shiovitz, Thomas M, Zarrow, Marlene E, Shiovitz, Andrew M, Bystritsky, Alexander M

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CNS sites cooperate to detect duplicate subjects with a clinical trial subject registry by Shiovitz, Thomas M, Wilcox, Charles S, Gevorgyan, Lilit, Shawkat, Adnan

“…To report the results of the first 1,132 subjects in a pilot project where local central nervous system trial sites collaborated in the use of a subject…”
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Effects of high-dose ziprasidone and haloperidol on the QTc interval after intramuscular administration: A randomized, single-blind, parallel-group study in patients with schizophrenia or schizoaffective disorder by Miceli, Jeffrey J., PhD, Tensfeldt, Thomas G., MS, Shiovitz, Thomas, MD, Anziano, Richard J., MS, O'Gorman, Cedric, MD, Harrigan, Rachel H., MD

“…Abstract Background: Antipsychotic agents have been associated with a prolonged QT interval. Data on the effects of ziprasidone and haloperidol on the QTc…”
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Extreme creatine phosphokinase elevation in a 20-year-old man participating in a clinical trial of major depressive disorder by Shiovitz, Thomas M, Song, Joo Lee, Manlosa, N Bailey, Seliverstov, Maria I, Sharma, Salila

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An Open-label, Intermediate-sized, Expanded Access Protocol of Rimegepant in the Acute Treatment of Migraine (P2-2.006) by Croop, Robert, Shiovitz, Thomas, Khan, Arifulla, Noonan, Tamara, Kaplita, Stephen, Seymour, E Mitchell, Jensen, Christopher, Coric, Vladimir

“…Abstract only…”
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Cholinergic Rebound and Rapid Onset Psychosis Following Abrupt Clozapine Withdrawal by Shiovitz, Thomas M., Welke, Timothy L., Tigel, Phillip D., Anand, Ravi, Hartman, Richard D., Sramek, John J., Kurtz, Neil M., Cutler, Neal R.

“…Following the conduct of a 28-day inpatient bioequivalence study of clozapine in schizophrenia patients, withdrawal effects after abrupt discontinuation from…”
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Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial by Coric, Vladimir, Salloway, Stephen, van Dyck, Christopher H, Dubois, Bruno, Andreasen, Niels, Brody, Mark, Curtis, Craig, Soininen, Hilkka, Thein, Stephen, Shiovitz, Thomas, Pilcher, Gary, Ferris, Steven, Colby, Susan, Kerselaers, Wendy, Dockens, Randy, Soares, Holly, Kaplita, Stephen, Luo, Feng, Pachai, Chahin, Bracoud, Luc, Mintun, Mark, Grill, Joshua D, Marek, Ken, Seibyl, John, Cedarbaum, Jesse M, Albright, Charles, Feldman, Howard H, Berman, Robert M

“…Early identification of Alzheimer disease (AD) is important for clinical management and affords the opportunity to assess potential disease-modifying agents in…”
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Pharmacokinetics and Tolerability of Buspirone during Oral Administration to Children and Adolescents with Anxiety Disorder and Normal Healthy Adults by Salazar, Daniel E., Frackiewicz, Edyta J., Dockens, Randy, Kollia, Georgia, Fulmor, I. Edgar, Tigel, Phillip D., Uderman, Howard D., Shiovitz, Thomas M., Sramek, John J., Cutler, Neal R.

“…A 21‐day, open‐label, multisite, dose escalation study comprising three demographic groups (children, adolescents, and adults) was performed to determine the…”
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Brasofensine Treatment for Parkinson's Disease in Combination with Levodopa/Carbidopa by Frackiewicz, Edyta J, Jhee, Stanford S, Shiovitz, Thomas M, Webster, Jonathan, Topham, Christine, Dockens, Randy C, Whigan, Daisy, Salazar, Daniel E, Cutler, Neal R

“…OBJECTIVE: To investigate the safety, tolerability, pharmacokinetic, and pharmacodynamic properties of the dopamine transporter antagonist brasofensine…”
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The Patient in Your Alzheimer’s Disease Study May be in Another: Duplication and Deception in Clinical Trials of Alzheimer’s Disease by Shiovitz, Thomas, Steinmiller, B., Steinmetz, C., Perez, S., Oseas, R.

“…Duplicate and deceptive subjects, a significant issue in CNS studies, are not often considered in Alzheimer’s Disease (AD) clinical trials. However, AD…”
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A Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Levomilnacipran ER 40-120mg/day for Prevention of Relapse in Patients with Major Depressive Disorder by Shiovitz, Thomas, Greenberg, William M, Chen, Changzheng, Forero, Giovanna, Gommoll, Carl P

“…Major depressive disorder is often chronic, with relapse and recurrence common. Levomilnacipran extended-release is a potent and selective serotonin and…”
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An 8-Week Multicenter, Parallel-Group, Double-Blind, Placebo-Controlled Study of Sertraline in Elderly Outpatients With Major Depression by Schneider, Lon S., Nelson, J. Craig, Clary, Cathryn M., Newhouse, Paul, Krishnan, K. Ranga Rama, Shiovitz, Thomas, Weihs, Karen

“…OBJECTIVE: There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This placebo-controlled…”
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Effects of Oral Ziprasidone and Oral Haloperidol on QTc Interval in Patients with Schizophrenia or Schizoaffective Disorder by Miceli, Jeffrey J., Tensfeldt, Thomas G., Shiovitz, Thomas, Anziano, Richard, O'Gorman, Cedric, Harrigan, Rachel H.

“…Study Objective. To characterize the effect of oral ziprasidone and haloperidol on the corrected QT (QTc) interval under steady‐state conditions. Design…”
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Placebo-controlled study of gabapentin treatment of Panic disorder by PANDE, A. C, POLLACK, M. H, CROCKATT, J, GREINER, M, CHOUINARD, G, LYDIARD, R. B, TAYLOR, C. B, DAGER, S. R, SHIOVITZ, T

“…A randomized, double-blind, placebo-controlled, parallel-group study was conducted to evaluate the efficacy and safety of gabapentin in relieving the symptoms…”
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Extreme Creatine Phosphokinase Elevation in a 20-Year-Old Man Participating in a Clinical Trail of Major Depressive Disorder by Shiovitz, Thomas M., Song, Joo Lee, Manlosa, N. Bailey, Seliverstov, Maria I., Sharma, Salila

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