Relapse in the External Auditory Canal of Acute Promyelocytic Leukemia after Treatment with All-Trans Retinoic Acid

A 54-year-old female was admitted to our hospital for gingival bleeding and was diagnosed as acute promyelocytic leukemia (APL). She received induction therapy according to the AML92 protocol of the Japan Adult Leukemia Study Group (JALSG) with all-trans retinoic acid (ATRA) plus chemotherapeutic ag...

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Bibliographic Details
Published in:	Internal Medicine Vol. 36; no. 7; pp. 484 - 486
Main Authors:	TOBITA, Tadasu, SHINJYO, Kaori, YANAGI, Mitsuaki, TAKESHITA, Akihiro, OHNISHI, Kazunori, OHNO, Ryuzo
Format:	Journal Article
Language:	English
Published:	Tokyo The Japanese Society of Internal Medicine 1997 Japanese Society of Internal Medicine
Subjects:	Agranulocytosis - chemically induced Agranulocytosis - drug therapy Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers, Tumor - analysis Combined Modality Therapy Cytarabine - administration & dosage Cytarabine - analogs & derivatives Daunorubicin - administration & dosage Ear Canal extramedullary disease Female Granulocyte Colony-Stimulating Factor - therapeutic use Hematologic and hematopoietic diseases Humans Idarubicin - administration & dosage leukemia cutis Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - pathology Leukemia, Promyelocytic, Acute - radiotherapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mercaptopurine - administration & dosage Middle Aged Mitoxantrone - administration & dosage Neoplasm Proteins - analysis Oncogene Proteins, Fusion - analysis Radiotherapy Recurrence Remission Induction Salvage Therapy Tretinoin - administration & dosage Vindesine - administration & dosage Antineoplastic agent Human Promyelocytic leukemia Drug combination Relapse Acute Malignant hemopathy Induction treatment Case study Chemotherapy Treatment External auditory canal ENT disease Female Retinoic acid
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Summary:	A 54-year-old female was admitted to our hospital for gingival bleeding and was diagnosed as acute promyelocytic leukemia (APL). She received induction therapy according to the AML92 protocol of the Japan Adult Leukemia Study Group (JALSG) with all-trans retinoic acid (ATRA) plus chemotherapeutic agents. She achieved complete remission, but one year later had a relapse in her external auditory canal without leukemic cell in the bone marrow. Extramedullary disease is rare in APL. This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA. (Internal Medicine 36: 484-486, 1997)
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.36.484