Search Results - "SHINJO, Kaori"

Depletion of Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatases 1 and 2 by Bcr-Abl Promotes Chronic Myelogenous Leukemia Cell Proliferation through Continuous Phosphorylation of Akt Isoforms by Hirano, Isao, Nakamura, Satoki, Yokota, Daisuke, Ono, Takaaki, Shigeno, Kazuyuki, Fujisawa, Shinya, Shinjo, Kaori, Ohnishi, Kazunori

“…The constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway commonly occurs in cancers and is a crucial event in tumorigenesis. Chronic…”
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Arsenic trioxide therapy in relapsed or refractory Japanese patients with acute promyelocytic leukemia : Updated outcomes of the phase II study and postremission therapies by SHIGENO, Kazuyuki, NAITO, Kensuke, SAHARA, Naohi, KOBAYASHI, Miki, NAKAMURA, Satoki, FUJISAWA, Sinya, SHINJO, Kaori, TAKESHITA, Akihiro, OHNO, Ryuzo, OHNISHI, Kazunori

“…Recently, arsenic trioxide (ATO) has been proved to induce complete remission (CR) at a high rate in patients with acute promyelocytic leukemia (APL). We…”
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Two cases of acute promyelocytic leukemia complicated by torsade de pointes during arsenic trioxide therapy by NAITO, Kensuke, KOBAYASHI, Miki, SAHARA, Naohi, SHIGENO, Kazuyuki, NAKAMURA, Satoki, SHINJO, Kaori, TOBITA, Tadasu, TAKESHITA, Akihiro, OHNO, Ryuzo, OHNISHI, Kazunori

“…We describe 2 patients with acute promyelocytic leukemia (APL) in whom torsade de pointes (TdP) developed during treatment with arsenic trioxide. Patient 1 was…”
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Biological markers for diagnosis of myeloid leukemia by Takeshita, Akihiro, Shinjo, Kaori

“…There are several important biological markers in myeloid leukemia. In particular, WT1, FLT3, P-glycoprotein (P-gp) and surface antigens are important biologic…”
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HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells by Sugimoto, Yuya, Nakamura, Satoki, Okinaka, Keiji, Hirano, Isao, Ono, Takaaki, Shigeno, Kazuyuki, Shinjo, Kaori, Ohnishi, Kazunori

“…Abstract Chronic myelogenous leukemia is characterized by the reciprocal chromosomal translocation (9;22), which generates a novel fusion gene, BCR-ABL…”
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KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells by Nakamura, Satoki, Okinaka, Keiji, Hirano, Isao, Ono, Takaaki, Sugimoto, Yuya, Shigeno, Kazuyuki, Fujisawa, Shinya, Shinjo, Kaori, Ohnishi, Kazunori

“…CEM, MOLT4 and SUP-B15 cells were transduced with lentivirus-mediated siRNA KIS gene. The mRNA expressions of KIS were successfully reduced in all cell lines…”
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Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells by Nakamura, Satoki, Kobayashi, Miki, Shibata, Kiyoshi, Sahara, Naohi, Shigeno, Kazuyuki, Shinjo, Kaori, Naito, Kensuke, Hayashi, Hideharu, Ohnishi, Kazunori

“…Cyclooxygenase-2 (COX-2) is reported to regulate apoptosis and to be an important cellular target for therapy. We examined whether etodolac, meloxicam, and…”
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Delayed Recovery of Normal Hematopoiesis in Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia: A Comparison to All-trans Retinoic Acid Treatment by SHINJO, Kaori, TAKESHITA, Akihiro, SAHARA, Naohi, KOBAYASHI, Miki, NAKAMURA, Satoki, SHIGENO, Kazuyuki, NAITO, Kensuke, MAEKAWA, Masato, OHNISHI, Kazunori, OHNO, Ryuzo

“…Objective To examine laboratory data including total blood cell count, leukocyte morphology and coagulation parameters during treatment for acute promyelocytic…”
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Two patients with all-trans retinoic acid-resistant acute promyelocytic leukemia treated successfully with gemtuzumab ozogamicin as a single agent by TAKESHITA, Akihiro, SHINJO, Kaori, YADA, Yoshihiro, TESHIMA, Hirofumi, TAKEUCHI, Jin, OHNISHI, Kazunori, OHNO, Ryuzo, NAITO, Kensuke, MATSUI, Hirotaka, SAHARA, Naohi, SHIGENO, Kazuyuki, SUZUMURA, Taeko, HORII, Toshinobu, SHIRAI, Naohito, MAEKAWA, Masato

“…Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower…”
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New Flow Cytometric Method for Detection of Minimally Expressed Multidrug Resistance P‐Glycoprotein on Normal and Acute Leukemia Cells Using Biotinylated MRK16 and Streptavidin‐RED670 Conjugate by Takeshita, Akihiro, Shinjo, Kaori, Ohnishl, Kazunori, Ohno, Ryuzo

“…To evaluate the expression of multidrug resistance (MDR) on normal and leukemia cells, we examined P‐glycoprotein (P‐gp) by a newly devised flow cytometric…”
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All-trans Retinoic Acid (ATRA) Differentiates Acute Promyelocytic Leukemia Cells Independently of P-Glycoprotein (P-gp) Related Multidrug Resistance by Takeshita, Akihiro, Shigeno, Kazuyuki, Shinjo, Kaori, Naito, Kensuke, Ohnishi, Kazunori, Hayashi, Hideharu, Tanimoto, Mitsune, Ohno, Ryuzo

“…Here the relationship between all-trans retinoic acid (ATRA)-resistance and P-glycoprotein (P-gp)-associated multidrug resistance (MDR) is discussed in acute…”
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Good prognosis of patients with acute promyelocytic leukemia who achieved second complete remission (CR) with a new retinoid, Am80, after relapse from CR induced by all-trans-retinoic acid by Shinjo, K, Takeshita, A, Ohnishi, K, Sakura, T, Miyawaki, S, Hiraoka, A, Takeuchi, M, Tomoyasu, S, Wakita, H, Ata, K, Fukutani, H, Ueda, R, Ohno, R

“…A new synthetic retinoid, Am80, is effective in treating acute promyelocytic leukemia relapsed from all-trans-retinoic acid-induced complete remission (CR). We…”
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Spicamycin and KRN5500 Induce Apoptosis in Myeloid and Lymphoid Cell Lines with Down‐regulation of Bcl‐2 Expression and Modulation of Promyelocytic Leukemia Protein by Zhang, Wen Jie, Ohnishi, Kazunori, Yoshida, Hitoshi, Pan, Ling, Maksumova, Lola, Muratkhodjaev, Farkhad, Luo, Jian Min, Shigeno, Kazuyuki, Fujisawa, Shinya, Naito, Kensuke, Nakamura, Satoki, Shinjo, Kaori, Takeshita, Akihiro, Ohno, Ryuzo

“…Spicamycin is a potent inducer of differentiation of human myeloid leukemia cells (HL‐60) and murine myeloid leukemia cells (M1). One of the spicamycin…”
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CMC‐544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B‐cell chronic lymphocytic leukaemia and lymphoma by Takeshita, Akihiro, Shinjo, Kaori, Yamakage, Nozomi, Ono, Takaaki, Hirano, Isao, Matsui, Hirotaka, Shigeno, Kazuyuki, Nakamura, Satoki, Tobita, Tadasu, Maekawa, Masato, Ohnishi, Kazunori, Sugimoto, Yoshikazu, Kiyoi, Hitoshi, Naoe, Tomoki, Ohno, Ryuzo

“…Summary The effect of CMC‐544, a calicheamicin‐conjugated anti‐CD22 monoclonal antibody, was analysed in relation to CD22 and P‐glycoprotein (P‐gp) in B‐cell…”
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Pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia treated with arsenic trioxide by FUJISAWA, Shinya, OHNO, Ryuzo, HASHIMOTO, Hisakuni, KINOSHITA, Kenji, SHIMOYA, Masahito, KAISE, Toshikazu, OHNISHI, Kazunori, SHIGENO, Kazuyuki, SAHARA, Naohi, NAKAMURA, Satoki, NAITO, Kensuke, KOBAYASHI, Miki, SHINJO, Kaori, TAKESHITA, Akihiro, SUZUKI, Yoshinari

“…To investigate the pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia (APL) treated with arsenic…”
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Retraction: Depletion of pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms by Hirano, Isao, Nakamura, Satoki, Yokota, Daisuke, Ono, Takaaki, Shigeno, Kazuyuki, Fujisawa, Shinya, Shinjo, Kaori, Ohnishi, Kazunori

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Depletion of pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms by Hirano, Isao, Nakamura, Satoki, Yokota, Daisuke, Ono, Takaaki, Shigeno, Kazuyuki, Fujisawa, Shinya, Shinjo, Kaori, Ohnishi, Kazunori

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Allergic Reaction Involving Liver Dysfunction and Disseminated Intravascular Coagulation Caused by a Health Food, Proporis by TAKESHITA, Akihiro, SHINJO, Kaori, OHNISHI, Kazunori, OHNO, Ryuzo

“…A 43-year-old woman was hospitalized with skin eruption and liver dysfunction complicated with disseminated intravascular coagulation (DIC) after taking…”
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Prolongation of the QT interval and ventricular tachycardia in patients treated with Arsenic trioxide for acute promyelocytic leukemia by OHNISHI, Kazunori, YOSHIDA, Hitoshi, SUGIYAMA, Shiho, SATOH, Hiroshi, TERADA, Hajime, OHNO, Ryuzo, SHIGENO, Kazuyuki, NAKAMURA, Satoki, FUJISAWA, Shinya, NAITO, Kensuke, SHINJO, Kaori, FUJITA, Yota, MATSUI, Hirotaka, TAKESHITA, Akihiro

“…Recently, arsenic trioxide has increasingly been used for relapsed acute promyelocytic leukemia. However, it is known to have several adverse effects,…”
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Abstract 5053: Depletion of PHLPP1 and 2 by Bcr-Abl promotes CML cell proliferation by Hirano, Isao, Nakamura, Satoki, Takemura, Tomonari, Yokota, Daisuke, Ono, Taka-aki, Shinjo, Kaori, Shigeno, Kazuyuki, Fujisawa, Shin-ya, Ohnishi, Kazunori

“…Abstract [Objective] PHLPP1 and 2 (pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 1 and 2) is identified as the dephosphorylation…”
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