Search Results - "SHING CHUAN HOOI"

A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers by Yu, Kun, Ganesan, Kumaresan, Tan, Lay Keng, Laban, Mirtha, Wu, Jeanie, Zhao, Xiao Dong, Li, Hongmin, Leung, Carol Ho Wing, Zhu, Yansong, Wei, Chia Lin, Hooi, Shing Chuan, Miller, Lance, Tan, Patrick

“…Successful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing…”
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Complex and novel determinants of empathy change in medical students by Sng, Gerald, Tung, Joshua, Ping, Yeo Su, Lee, Shuh Shing, Win, Ma Thin Mar, Hooi, Shing Chuan, Samarasekera, Dujeepa D

“…Physician empathy is a core attribute in medical professionals, giving better patient outcomes. Medical school is an opportune time for building empathetic…”
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Improving a newly adapted teaching and learning approach by Shuh Shing Lee, Shing Chuan Hooi, Terry Pan, Chong Hui Ann Fong, Dujeepa D. Samarasekera

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Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective by Ong, Mei Shan, Deng, Shuo, Halim, Clarissa Esmeralda, Cai, Wanpei, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T

“…Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival…”
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FOXQ1 Regulates Epithelial-Mesenchymal Transition in Human Cancers by YUANYUAN QIAO, XIA JIANG, THENG LEE, Shuet, MURTHY KARUTURI, R. K, SHING CHUAN HOOI, QIANG YU

“…Epithelial-mesenchymal transition (EMT) in cancer cells plays a pivotal role in determining metastatic prowess, but knowledge of EMT regulation remains…”
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Perceived challenges and opportunities for basic scientists transitioning to basic science educators in medical and health professions education by Wong, Lik-Wei, Wong, Amanda Huee-Ping, Lian, Derrick Wen Quan, Hooi, Shing Chuan

“…Basic science educators play a significant role in medical and health professions curricula, particularly in the biomedical science components. Although the…”
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HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population by LER, SER YENG, LEUNG, CAROL HO WING, KHIN, LAY WAI, LU, GUO-DONG, SALTO-TELLEZ, MANUEL, HARTMAN, MIKAEL, IAU, PHILIP TSAU CHOONG, YAP, CELESTIAL T, HOOI, SHING CHUAN

“…Histone deacetylases (HDACs) are enzymes involved in transcriptional repression. We aimed to examine the significance of HDAC1 and HDAC2 gene expression in the…”
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Acetyl‐keto‐β‐boswellic acid inhibits cellular proliferation through a p21‐dependent pathway in colon cancer cells by Liu, Jian‐Jun, Huang, Baohua, Hooi, Shing Chuan

“…1 Although there is increasing evidence showing that boswellic acid might be a potential anticancer agent, the mechanisms involved in its action are unclear. 2…”
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AKT activation was not essential for hepatocellular carcinoma cell survival under glucose deprivation by Zhou, Jing, Tang, Yue, Xie, Ze-Jun, Lu, Jing-Ning, Deng, Jing-Huan, Huang, Xiao-Wei, Chuan Hooi, Shing, He, Min, Lu, Guo-Dong

“…Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, with a dismal 5-year survival rate less than 15%. The present…”
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The pro-survival function of DLEC1 and its protection of cancer cells against 5-FU-induced apoptosis through up-regulation of BCL-XL by Qiu, Guo-Hua, Que, Wutang, Yan, Shanying, Zheng, Xintian, Xie, Xiaojin, Huang, Cuiqin, Yang, Xiaoyan, Hooi, Shing Chuan

“…The tumor suppressor DLEC1 has been shown to promote cell proliferation when AP-2α2 is down-regulated in HCT116 stable clones, suggesting its pro-survival…”
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Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade by Zhuo, Jingli, Tan, Ee Hong, Yan, Benedict, Tochhawng, Lalchhandami, Jayapal, Manikandan, Koh, Shiuan, Tay, Hwee Kee, Maciver, Sutherland K, Hooi, Shing Chuan, Salto-Tellez, Manuel, Kumar, Alan Prem, Goh, Yaw Chong, Lim, Yaw Chyn, Yap, Celestial T

“…Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a…”
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The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle by Qiu, Guo-Hua, Salto-Tellez, Manuel, Ross, James A, Yeo, Winnie, Cui, Yan, Wheelhouse, Nicholas, Chen, George G, Harrison, David, Lai, Paul, Tao, Qian, Hooi, Shing Chuan

“…Background/Aims The chromosome locus 3p21.3 is a “hot-spot” for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20…”
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Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma by Qiu, Guo-Hua, Xie, Huangming, Wheelhouse, Nicholas, Harrison, David, Chen, George G, Salto-Tellez, Manuel, Lai, Paul, Ross, James A, Hooi, Shing Chuan

“…Background/Aims hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB , in normal tissues, and the…”
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Improving a newly adapted teaching and learning approach: Collaborative Learning Cases using an action research by Lee, Shuh Shing, Hooi, Shing Chuan, Pan, Terry, Fong, Chong Hui Ann, Samarasekera, Dujeepa D

“…Although medical curricula are now better structured for integration of biomedical sciences and clinical training, most teaching and learning activities still…”
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Palladin, an actin-associated protein, is required for adherens junction formation and intercellular adhesion in HCT116 colorectal cancer cells by PUEI NAM TAY, TAN, Patrick, THERESE YAP, Celestial, HSIU KIM LIM, Lina, YAW CHYN LIM, SHING CHUAN HOOI, YUHONG LAN, LEUNG, Carol Ho-Wing, LABAN, Mirtha, CHIN TAN, Tze, HONGMIN NI, MANIKANDAN, Jayapal, BIN ABDUL RASHID, Suhaimi, YAN, Benedict

“…Palladin is a scaffold protein involved in the formation of actin-associated protein complexes. Gene expression array analysis on the poorly metastatic HCT116…”
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CCAAT/enhancer binding protein a knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma by EE HONG TAN, SHING CHUAN HOOI, LABAN, Mirtha, WONG, Esther, PONNIAH, Sathivel, WEE, Aileen, WANG, Nai-Dy

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Effectiveness of early cardiology undergraduate learning using simulation on retention, application of learning and level of confidence during clinical clerkships by Lin, Weiqin, Lee, Glenn K, Loh, Joshua P, Tay, Edgar L, Sia, Winnie, Lau, Tang-Ching, Hooi, Shing-Chuan, Poh, Kian-Keong

“…This study aimed to assess the effectiveness of the use of a cardiopulmonary patient simulator in the teaching of second-year medical students. Effectiveness…”
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Proteome analysis of butyrate‐treated human colon cancer cells (HT‐29) by Tan, Sandra, Seow, Teck Keong, Liang, Rosa Cynthia M.Y., Koh, Shiuan, Lee, Christine P.C., Chung, Maxey C.M., Hooi, Shing Chuan

“…Butyrate, a 4‐carbon fatty acid, has been shown to cause growth arrest and apoptosis of cancer cells in vitro and in vivo. The signaling pathways leading to…”
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The proline-rich acidic protein is epigenetically regulated and inhibits growth of cancer cell lines by JINQIU ZHANG, HANGYEE WONG, RAMANAN, Sriram, CHEONG, Denis, LEONG, Adrian, SHING CHUAN HOOI

“…The proline-rich acidic protein (PRAP) gene was found previously to be expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and…”
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Heparin/heparan sulfate interacting protein plays a role in apoptosis induced by anticancer drugs by Liu, Jian-Jun, Zhang, Jinqiu, Ramanan, Sriram, Julian, JoAnne, Carson, Daniel D., Hooi, Shing Chuan

“…Heparin/heparan sulfate interacting protein (HIP, also known as ribosome protein L29) is involved in cell–cell and cell–extracelluar matrix interactions and…”
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