Search Results - "SHINDLER, Kenneth S"

CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination by Saadi, Fareeha, Chakravarty, Debanjana, Kumar, Saurav, Kamble, Mithila, Saha, Bhaskar, Shindler, Kenneth S, Das Sarma, Jayasri

“…Neurotropic mouse hepatitis virus (MHV-A59/RSA59) infection in mice induces acute neuroinflammation due to direct neural cell dystrophy, which proceeds with…”
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SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis by McDougald, Devin S, Dine, Kimberly E, Zezulin, Alexandra U, Bennett, Jean, Shindler, Kenneth S

“…Optic neuritis is a condition defined by autoimmune-mediated demyelination of the optic nerve and death of retinal ganglion cells. SIRT1 and NRF2 stimulate…”
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Intranasal Resveratrol Nanoparticles Enhance Neuroprotection in a Model of Multiple Sclerosis by Shamsher, Ehtesham, Khan, Reas S, Davis, Benjamin M, Dine, Kimberly, Luong, Vy, Cordeiro, M Francesca, Shindler, Kenneth S

“…Resveratrol is a natural polyphenol which has a very low bioavailability but whose antioxidant, anti-inflammatory and anti-apoptotic properties may have…”
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SIRT1 promotes RGC survival and delays loss of function following optic nerve crush by Zuo, Ling, Khan, Reas S, Lee, Vivian, Dine, Kimberly, Wu, Wen, Shindler, Kenneth S

“…Activation of SIRT1 deacetylase prevents retinal ganglion cell (RGC) loss in experimental optic neuritis, an inflammatory optic neuropathy. While mechanisms of…”
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Socioeconomic and Geographic Disparities in Idiopathic Intracranial Hypertension by Brahma, Venkatesh L., Snow, Jonathan, Tam, Vicky, Ross, Ahmara G., Tamhankar, Madhura A., Shindler, Kenneth S., Avery, Robert A., Liu, Grant T., Hamedani, Ali G.

“…To identify relationships between idiopathic intracranial hypertension (IIH) and socioeconomic determinants of health, such as low-income status and proximity…”
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Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis by Khan, Reas S., Baumann, Bailey, Dine, Kimberly, Song, Ying, Dunaief, Joshua L., Kim, Sangwon F., Shindler, Kenneth S.

“…Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative…”
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Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis by Fonseca-Kelly, Zoe, Nassrallah, Mayssa, Uribe, Jorge, Khan, Reas S, Dine, Kimberly, Dutt, Mahasweta, Shindler, Kenneth S

“…Resveratrol is a naturally occurring polyphenol that activates SIRT1, an NAD-dependent deacetylase. SRT501, a pharmaceutical formulation of resveratrol with…”
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Neuroprotection mediated by ST266 requires full complement of proteins secreted by amnion-derived multipotent progenitor cells by Willett, Keirnan, Khan, Reas S, Dine, Kimberly, Wessel, Howard, Kirshner, Ziv Z, Sauer, Jodie L, Ellis, Ashley, Brown, Larry R, Shindler, Kenneth S

“…ST266 is the biological secretome of cultured Amnion-derived Multipotent Progenitor cells containing multiple growth factors and cytokines. While…”
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SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis by Shindler, Kenneth S, Ventura, Elvira, Rex, Tonia S, Elliott, Peter, Rostami, Abdolmohamad

“…Axonal damage and loss of neurons correlate with permanent vision loss and neurologic disability in patients with optic neuritis and multiple sclerosis (MS)…”
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The human visual cortex responds to gene therapy-mediated recovery of retinal function by Ashtari, Manzar, Cyckowski, Laura L, Monroe, Justin F, Marshall, Kathleen A, Chung, Daniel C, Auricchio, Alberto, Simonelli, Francesca, Leroy, Bart P, Maguire, Albert M, Shindler, Kenneth S, Bennett, Jean

“…Leber congenital amaurosis (LCA) is a rare degenerative eye disease, linked to mutations in at least 14 genes. A recent gene therapy trial in patients with…”
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Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema by Mallery, Robert M, Rehmani, Obeidurahman F, Woo, John H, Chen, Yin Jie, Reddi, Sudama, Salzman, Karen L, Pinho, Marco C, Ledbetter, Luke, Tamhankar, Madhura A, Shindler, Kenneth S, Digre, Kathleen B, Friedman, Deborah I, Liu, Grant T

“…OBJECTIVE:Revised diagnostic criteria for idiopathic intracranial hypertension (IIH) were proposed in part to reduce misdiagnosis of intracranial hypertension…”
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SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells by Khan, Reas S, Fonseca-Kelly, Zoe, Callinan, Catherine, Zuo, Ling, Sachdeva, Mira M, Shindler, Kenneth S

“…Activation of SIRT1, an NAD+-dependent deacetylase, prevents retinal ganglion cell (RGC) loss in optic neuritis, an inflammatory demyelinating optic nerve…”
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Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity by Chen, Yong, Khan, Reas S, Cwanger, Alyssa, Song, Ying, Steenstra, Catherine, Bang, Sookhee, Cheah, Jaime H, Dunaief, Joshua, Shindler, Kenneth S, Snyder, Solomon H, Kim, Sangwon F

“…Dexras1, a small G-protein localized predominantly to the brain, is transcriptionally upregulated by the synthetic glucocorticoid dexamethasone. It has close…”
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Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis by Das Sarma, Jayasri, Ciric, Bogoljub, Marek, Ryan, Sadhukhan, Sanjoy, Caruso, Michael L, Shafagh, Jasmine, Fitzgerald, Denise C, Shindler, Kenneth S, Rostami, Am

“…Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune…”
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Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis by Ross, Ahmara G, Chaqour, Brahim, McDougald, Devin S, Dine, Kimberly E, Duong, Thu T, Shindler, Ryan E, Yue, Jipeng, Liu, Tehui, Shindler, Kenneth S

“…Optic neuritis (ON), the most common ocular manifestation of multiple sclerosis, is an autoimmune inflammatory demyelinating disease also characterized by…”
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Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis by Quinn, Thomas A, Dutt, Mahasweta, Shindler, Kenneth S

“…Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are neurodegenerative diseases with characteristic inflammatory…”
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Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis by Singh, Manmeet, Khan, Reas S, Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S

“…Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal…”
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Resolution of COVID-19 induced anosmia following treatment with ST266 by Bhutani, Devica L., Ross, Ahmara G., Lehman, Amanda Y., Shindler, Kenneth S.

“…Persistent anosmia following COVID-19 disease affects a significant subset of patients. Symptoms of this olfactory dysfunction negatively impact patient…”
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SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease by Khan, Reas S, Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S

“…Multiple sclerosis (MS) is characterized by central nervous system inflammation and demyelination, and increasing evidence demonstrates significant neuronal…”
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Mouse hepatitis virus infection upregulates genes involved in innate immune responses by Chatterjee, Dhriti, Addya, Sankar, Khan, Reas S, Kenyon, Lawrence C, Choe, Alexander, Cohrs, Randall J, Shindler, Kenneth S, Sarma, Jayasri Das

“…Neurotropic recombinant strain of Mouse Hepatitis Virus, RSA59, induces meningo-encephalitis, myelitis and demyelination following intracranial inoculation…”
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