Search Results - "SHIN, Haina"

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2 by Shin, Haina, Kumamoto, Yosuke, Gopinath, Smita, Iwasaki, Akiko

“…Tissue-resident memory CD8+ T (CD8 T RM ) cells are an essential component of protective immune responses at barrier tissues, including the female genital…”
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Generating protective immunity against genital herpes by Shin, Haina, Iwasaki, Akiko

“…Highlights • HSV shedding occurs with great frequency and cannot be entirely controlled. • Tissue-resident T cells mediate control of HSV-2 infection. •…”
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Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade by Blackburn, Shawn D, Shin, Haina, Freeman, Gordon J, Wherry, E. John

“…Programmed death-1 (PD-1) regulates T cell exhaustion during chronic infections. Blocking the PD-1:PD-ligand (PD-L) pathway reinvigorates exhausted CD8 T…”
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A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection by Lebratti, Tania, Lim, Ying Shiang, Cofie, Adjoa, Andhey, Prabhakar, Jiang, Xiaoping, Scott, Jason, Fabbrizi, Maria Rita, Ozantürk, Ayşe Naz, Pham, Christine, Clemens, Regina, Artyomov, Maxim, Dinauer, Mary, Shin, Haina

“…Neutrophil responses against pathogens must be balanced between protection and immunopathology. Factors that determine these outcomes are not well-understood…”
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Low-dose inoculation of Escherichia coli achieves robust vaginal colonization and results in ascending infection accompanied by severe uterine inflammation in mice by O'Brien, Valerie P, Gilbert, Nicole M, Lebratti, Tania, Agarwal, Kavita, Foster, Lynne, Shin, Haina, Lewis, Amanda L

“…Escherichia coli infection of the female reproductive tract is a significant cause of disease in humans and animals, but simple animal models are lacking. Here…”
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NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection by Lim, Ying Shiang, Lee, Aisha G., Jiang, Xiaoping, Scott, Jason M., Cofie, Adjoa, Kumar, Sandeep, Kennedy, Dania, Granville, David J., Shin, Haina

“…Genital herpes is characterized by recurrent episodes of epithelial blistering. The mechanisms causing this pathology are ill defined. Using a mouse model of…”
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Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion by BLACKBURN, Shawn D, CRAWFORD, Alison, SHIN, Haina, POLLEY, Antonio, FREEMAN, Gordon J, WHERRY, E. John

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Simplified Quantitative Real-Time PCR Assay for Monitoring SARS-CoV-2 Growth in Cell Culture by Shema Mugisha, Christian, Vuong, Hung R, Puray-Chavez, Maritza, Bailey, Adam L, Fox, Julie M, Chen, Rita E, Wessel, Alex W, Scott, Jason M, Harastani, Houda H, Boon, Adrianus C M, Shin, Haina, Kutluay, Sebla B

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions within just a few months, causing severe respiratory disease and mortality…”
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Skin T_RM mediates distributed border patrol by Haina Shin Akiko Iwasak

“…Tissue-resident memory T cells T_RM are a new subset of memory cells that have been associated with enhanced protective immunity for their tissue of residence…”
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A vaccine strategy that protects against genital herpes by establishing local memory T cells by Shin, Haina, Iwasaki, Akiko

“…A genital herpes simplex vaccine strategy of immunization using attenuated virus with peripheral local chemokine application can establish a population of…”
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Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells by Wiehagen, Karla R., Corbo, Evann, Schmidt, Michelle, Shin, Haina, Wherry, E. John, Maltzman, Jonathan S.

“…The requirements for tonic T-cell receptor (TCR) signaling in CD8+ memory T-cell generation and homeostasis are poorly defined. The SRC homology 2…”
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Tissue-resident memory T cells by Shin, Haina, Iwasaki, Akiko

“…Summary Tissues such as the genital tract, skin, and lung act as barriers against invading pathogens. To protect the host, incoming microbes must be quickly…”
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Formation and function of tissue-resident memory T cells during viral infection by Shin, Haina

“…•TRM are abundant in a wide range of tissues in both mice and humans.•Environmental cues instruct TRM differentiation.•TRM protect against numerous viruses at…”
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CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity by Lim, Ying Shiang, Shin, Haina

“…Tissue-resident memory T (TRM) cells exert antiviral effects in situ using a variety of cell-intrinsic mechanisms. In this issue of Mucosal Immunology, Rosato…”
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CD8 T cell dysfunction during chronic viral infection by Shin, Haina, Wherry, E John

“…Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By…”
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Coregulation of CD8 + T cell exhaustion by multiple inhibitory receptors during chronic viral infection by Shin, Haina, Haining, W Nicholas, Wherry, E John, Betts, Michael R, Polley, Antonio, Blackburn, Shawn D, Vignali, Dario A A, Zou, Tao, Workman, Creg J, Freeman, Gordon J

“…Chronic infection can lead to T cell exhaustion. Wherry and colleagues demonstrate that a hierarchy of inhibitory receptors coregulate CD8 + T cell exhaustion…”
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Avaccine strategy that protects against genital herpes by establishing local memory T cells by Shin, Haina, Iwasaki, Akiko

“…Most successful existing vaccines rely on neutralizing antibodies, which may not require specific anatomical localization of B cells. However, efficacious…”
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A vaccine strategy protects against genital herpes by establishing local memory T cells by Shin, Haina, Iwasaki, Akiko

“…The majority of successful existing vaccines rely on neutralizing antibodies, which may not require specific anatomical localization of B cells. However,…”
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A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection by Shin, Haina, Blackburn, Shawn D., Intlekofer, Andrew M., Kao, Charlly, Angelosanto, Jill M., Reiner, Steven L., Wherry, E. John

“…T cell exhaustion is common during chronic infections and can prevent optimal immunity. Although recent studies have demonstrated the importance of inhibitory…”
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Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice by Scott, Jason M, Lebratti, Tania J, Richner, Justin M, Jiang, Xiaoping, Fernandez, Estefania, Zhao, Haiyan, Fremont, Daved H, Diamond, Michael S, Shin, Haina

“…Zika virus (ZIKV), which can cause devastating disease in fetuses of infected pregnant women, can be transmitted by mosquito inoculation and sexual routes…”
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