Search Results - "SHIMOZAWA, Nobuhiro"

Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study by Ando, Sana, Sakurai, Masashi, Shibutani, Shusaku, Kimura, Nobuyuki, Shimozawa, Nobuhiro, Yasutomi, Yasuhiro, Yabe, Ryotaro, Ohama, Takashi, Sato, Koichi

“…The abnormal activity of PP2A, a dominant member of type 2A serine/threonine protein phosphatase, has been implicated in the development of Alzheimer's disease…”
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A controlled ovarian stimulation procedure suitable for cynomolgus macaques by Shimozawa, Nobuhiro, Iwata, Takeshi, Yasutomi, Yasuhiro

“…This study aimed to develop a more suitable ovarian stimulation procedure for cynomolgus macaques (Macaca fascicularis). Macaques were divided into 4 groups,…”
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Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma by Shiga, Yukihiro, Akiyama, Masato, Nishiguchi, Koji M, Sato, Kota, Shimozawa, Nobuhiro, Takahashi, Atsushi, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Yamaji, Taiki, Iwasaki, Motoki, Tsugane, Shoichiro, Oze, Isao, Mikami, Haruo, Naito, Mariko, Wakai, Kenji, Yoshikawa, Munemitsu, Miyake, Masahiro, Yamashiro, Kenji, Kashiwagi, Kenji, Iwata, Takeshi, Mabuchi, Fumihiko, Takamoto, Mitsuko, Ozaki, Mineo, Kawase, Kazuhide, Aihara, Makoto, Araie, Makoto, Yamamoto, Tetsuya, Kiuchi, Yoshiaki, Nakamura, Makoto, Ikeda, Yasuhiro, Sonoda, Koh-Hei, Ishibashi, Tatsuro, Nitta, Koji, Iwase, Aiko, Shirato, Shiroaki, Oka, Yoshitaka, Satoh, Mamoru, Sasaki, Makoto, Fuse, Nobuo, Suzuki, Yoichi, Cheng, Ching-Yu, Khor, Chiea Chuen, Baskaran, Mani, Perera, Shamira, Aung, Tin, Vithana, Eranga N, Cooke Bailey, Jessica N, Kang, Jae H, Pasquale, Louis R, Haines, Jonathan L, Wiggs, Janey L, Burdon, Kathryn P, Gharahkhani, Puya, Hewitt, Alex W, Mackey, David A, MacGregor, Stuart, Craig, Jamie E, Allingham, R Rand, Hauser, Micheal, Ashaye, Adeyinka, Budenz, Donald L, Akafo, Stephan, Williams, Susan E I, Kamatani, Yoichiro, Nakazawa, Toru, Kubo, Michiaki

“…Abstract Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered…”
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Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates by Okabayashi, Sachi, Shimozawa, Nobuhiro, Yasutomi, Yasuhiro, Yanagisawa, Katsuhiko, Kimura, Nobuyuki

“…Growing evidence suggests that diabetes mellitus (DM) is one of the strongest risk factors for developing Alzheimer's disease (AD). However, it remains unclear…”
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Ultrasound-guided, Transabdominal, Intrauterine Artificial Insemination for Cynomolgus Macaques (Macaca fascicularis) Based on Estimated Timing of Ovulation by Shimozawa, Nobuhiro, Ageyama, Naohide, Nakayama, Shunya, Koie, Hiroshi, Yasutomi, Yasuhiro

“…Intrauterine sperm injection for artificial insemination is difficult in cynomolgus macaques (Macaca fascicularis) and rhesus macaques (M. mulatta) due to the…”
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Identification of TEKTIN1‐expressing multiciliated cells during spontaneous differentiation of non‐human primate embryonic stem cells by Nishie, Tomomi, Ohta, Yoshio, Shirai, Emi, Higaki, Shogo, Shimozawa, Nobuhiro, Narita, Keishi, Kawaguchi, Kotoku, Tanaka, Hideyuki, Mori, Chika, Tanaka, Taiga, Hirabayashi, Masumi, Suemori, Hirofumi, Kurisaki, Akira, Tooyama, Ikuo, Asano, Shinji, Takeda, Sén, Takada, Tatsuyuki

“…Tektins are a group of microtubule‐stabilizing proteins necessary for cilia and flagella assembly. TEKTIN1 (TEKT1) is used as a sperm marker for monitoring…”
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The Expression of Rab8, Ezrin, Radixin and Moesin in the Ciliary Body of Cynomolgus Monkeys by TANABE, KAZUHIKO, KIMURA, ITARU, OKAMOTO, HARU, CHI, ZAI-LONG, AKAHORI, MASAKAZU, SHIMOZAWA, NOBUHIRO, EBIHARA, NOBUYUKI, MURAKAMI, AKIRA, IWATA, TAKESHI

“…Purpose The purpose of this study was to determine what proteins are present in the ciliary body (CB). To accomplish this, we conducted a proteomic analysis of…”
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Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis by Yamauchi, Toshimasa, Kamon, Junji, Waki, Hironori, Imai, Yasushi, Shimozawa, Nobuhiro, Hioki, Kyouji, Uchida, Shoko, Ito, Yusuke, Takakuwa, Keisuke, Matsui, Junji, Takata, Makoto, Eto, Kazuhiro, Terauchi, Yasuo, Komeda, Kajuro, Tsunoda, Masaki, Murakami, Koji, Ohnishi, Yasuyuki, Naitoh, Takeshi, Yamamura, Kenichi, Ueyama, Yoshito, Froguel, Philippe, Kimura, Satoshi, Nagai, Ryozo, Kadowaki, Takashi

“…The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this…”
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Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis by Nishiguchi, Koji M, Yokoyama, Yu, Fujii, Yusuke, Fujita, Kosuke, Tomiyama, Yusuke, Kawasaki, Ryo, Furukawa, Toshinori, Ono, Fumiko, Shimozawa, Nobuhiro, Togo, Mutsumi, Suzuki, Michihiro, Nakazawa, Toru

“…Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the…”
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Cloned Mice from Fetal Fibroblast Cells Arrested at Metaphase by a Serial Nuclear Transfer by ONO, Yukiko, SHIMOZAWA, Nobuhiro, ITO, Mamoru, KONO, Tomohiro

“…Cloning using G 0 -arrested somatic cells has led to the suggestion that this stage of the cell cycle is necessary for the success of cloning. In this study we…”
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Characterization of a novel embryonic stem cell line from an ICSI-derived blastocyst in the African green monkey by Shimozawa, Nobuhiro, Nakamura, Shinichiro, Takahashi, Ichiro, Hatori, Masanori, Sankai, Tadashi

“…Several cell types from the African green monkey (Cercopithecus aethiops), such as red blood cells, primary culture cells from kidney, and the Vero cell line,…”
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KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration by Muraoka, Yuki, Iida, Yuto, Ikeda, Hanako O., Iwai, Sachiko, Hata, Masayuki, Iwata, Takeshi, Nakayama, Mao, Shimozawa, Nobuhiro, Katakai, Yuko, Kakizuka, Akira, Yoshimura, Nagahisa, Tsujikawa, Akitaka

“…Age-related macular degeneration (AMD) is a leading cause of blindness among elderly people. The appearance of drusen is a clinical manifestation and a…”
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Protocol for the production of viable bimaternal mouse embryos by Kono, Tomohiro, Kawahara, Manabu, Obata, Yayoi, Sotomaru, Yusuke, Shimozawa, Nobuhiro, Bao, Siqin, Tsukadaira, Toshitaka, Fukuda, Atsushi

“…A reliable nuclear transfer method was first reported in 1983; it provided definite evidence that parthenogenetic embryos are lethal at early postimplantation…”
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Cynomolgus Monkey Induced Pluripotent Stem Cells Generated By Using Allogeneic Genes by Shimozawa, Nobuhiro

“…Induced pluripotent stem (iPS) cells that are potentially similar to embryonic stem (ES) cells can be artificially established by introduction into somatic…”
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Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain by Koinuma, Shingo, Shimozawa, Nobuhiro, Yasutomi, Yasuhiro, Kimura, Nobuyuki

“…•Autophagosome-related proteins are reduced and intraneuronal Aβ increased in normal aged monkey brains.•Autophagosome formation influences EV secretion in…”
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Phenotypic abnormalities observed in aged cloned mice from embryonic stem cells after long-term maintenance by Shimozawa, Nobuhiro, Sotomaru, Yusuke, Eguchi, Natsuko, Suzuki, Shuzo, Hioki, Kyoji, Usui, Toshimi, Kono, Tomohiro, Ito, Mamoru

“…Somatic/embryonic stem cell cloning has made it possible to produce an individual genomically identical to another individual. However, the cloned animals have…”
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MONITORING OF GENE EXPRESSION IN DIFFERENTIATION OF EMBRYOID BODIES FROM CYNOMOLGUS MONKEY EMBRYONIC STEM CELLS IN THE PRESENCE OF BISPHENOL A by YAMAMOTO, Megumi, TASE, Naomi, OKUNO, Tsuyoshi, KONDO, Yasushi, AKIBA, Suminori, SHIMOZAWA, Nobuhiro, TERAO, Keiji

“…An embryonic stem (ES) cell differentiation model would facilitate analysis of developmental processes at the cellular level and the effects of embryotoxic and…”
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A controlled ovarian stimulation procedure suitable for cynomolgus macaques by SHIMOZAWA, Nobuhiro, IWATA, Takeshi, YASUTOMI, Yasuhiro

“…This study aimed to develop a more suitable ovarian stimulation procedure for cynomolgus macaques (Macaca fascicularis). Macaques were divided into 4 groups,…”
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Collection and culture of primordial germ cells from cynomolgus monkeys (Macaca fascicularis) by OKADA, HIRONORI, HATORI, MASANORI, SHIMOZAWA, NOBUHIRO, TSUCHIYA, HIDEAKI, KUWANA, TAKASHI, SANKAI, TADASHI

“…Aim:  To clarify the location of primordial germ cells (PGC) in an embryo of target‐age and to examine the culture environment of the PCG. Methods:  The days…”
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Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus by Takeuchi, Shingo, Ueda, Naoya, Suzuki, Keiko, Shimozawa, Nobuhiro, Yasutomi, Yasuhiro, Kimura, Nobuyuki

“…The endocytic membrane trafficking system is altered in the brains of early-stage Alzheimer disease (AD) patients, and endocytic disturbance affects the…”
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