Search Results - "SHIMOMURA, Kenju"

TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice by Ono, Yuko, Maejima, Yuko, Saito, Masafumi, Sakamoto, Kazuho, Horita, Shoichiro, Shimomura, Kenju, Inoue, Shigeaki, Kotani, Joji

“…Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or various endogenous diseases related to bacterial…”
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The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma by Jojima, Teruo, Wakamatsu, Sho, Kase, Masato, Iijima, Toshie, Maejima, Yuko, Shimomura, Kenju, Kogai, Takahiko, Tomaru, Takuya, Usui, Isao, Aso, Yoshimasa

“…The aim of the present study is to investigate the effects of canagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, on non-alcoholic…”
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KATP Channel Mutations and Neonatal Diabetes by Shimomura, Kenju, Maejima, Yuko

“…Since the discovery of the KATP channel in 1983, numerous studies have revealed its physiological functions. The KATP channel is expressed in various organs,…”
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Urinary Excretion of Nadolol as a Possible In Vivo Probe for Drug Interactions Involving P‐Glycoprotein by Shimazaki, Sho, Kuroda, Junko, Shimomura, Kenju, Misaka, Shingen

“…Nadolol is a hydrophilic and nonselective β‐adrenoceptor blocker with a bioavailability of 30%, relatively longer half‐life, negligible metabolism, and…”
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Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans? by Misaka, Shingen, Shimomura, Kenju

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Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models by Horiai, Machi, Otsuka, Ayano, Hidema, Shizu, Hiraoka, Yuichi, Hayashi, Ryotaro, Miyazaki, Shinji, Furuse, Tamio, Mizukami, Hiroaki, Teruyama, Ryoichi, Tamura, Masaru, Bito, Haruhiko, Maejima, Yuko, Shimomura, Kenju, Nishimori, Katsuhiko

“…Autism spectrum disorder (ASD) is a continuum of neurodevelopmental disorders and needs new therapeutic approaches. Recently, oxytocin (OXT) showed potential…”
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Reversible changes in pancreatic islet structure and function produced by elevated blood glucose by Brereton, Melissa F., Iberl, Michaela, Shimomura, Kenju, Zhang, Quan, Adriaenssens, Alice E., Proks, Peter, Spiliotis, Ioannis I., Dace, William, Mattis, Katia K., Ramracheya, Reshma, Gribble, Fiona M., Reimann, Frank, Clark, Anne, Rorsman, Patrik, Ashcroft, Frances M.

“…Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell…”
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Early life high-fat diet exposure evokes normal weight obesity by Maejima, Yuko, Yokota, Shoko, Horita, Shoichiro, Shimomura, Kenju

“…Abstract Obesity is becoming one of the most severe global health problems. However, risk of developing normal weight obesity, where an individual has a high…”
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Single administration of resveratrol improves social behavior in adult mouse models of autism spectrum disorder by Hidema, Shizu, Kikuchi, Shohei, Takata, Ryoji, Yanai, Takaaki, Shimomura, Kenju, Horie, Kengo, Nishimori, Katsuhiko

“…Resveratrol (RSV) is a natural polyphenol present in grapes, the skin of peanuts, and several other plants with many health benefits. Autism spectrum disorder…”
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Efficacy of SGLT2 inhibitors as additional treatment in Japanese type 2 diabetic patients: second or third choice? by Fujiwara, Makoto, Shimizu, Masaru, Maejima, Yuko, Shimomura, Kenju

“…Due to the increase of type 2 diabetes (T2D), the number of patients in treatment with multiple anti-diabetic agents is increased. According to the recent…”
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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells by Brereton, Melissa F., Rohm, Maria, Shimomura, Kenju, Holland, Christian, Tornovsky-Babeay, Sharona, Dadon, Daniela, Iberl, Michaela, Chibalina, Margarita V., Lee, Sheena, Glaser, Benjamin, Dor, Yuval, Rorsman, Patrik, Clark, Anne, Ashcroft, Frances M.

“…Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including…”
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Central action of ELABELA reduces food intake and activates arginine vasopressin and corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus by Santoso, Putra, Maejima, Yuko, Kumamoto, Kensuke, Takenoshita, Seiichi, Shimomura, Kenju

“…ELABELA (ELA) is a novel hormone consisting of 32 amino acid peptides found in humans as well as other vertebrates and is considered to play an important role…”
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Sex differences in the effects of aromatherapy on anxiety and salivary oxytocin levels by Nakajima, Daisuke, Yamachi, Megumi, Misaka, Shingen, Shimomura, Kenju, Maejima, Yuko

“…Aromatherapy is a holistic healing method to promote health and well-being by using natural plant extracts. However, its precise mechanism of action and…”
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The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats by Maejima, Yuko, Yokota, Shoko, Horita, Shoichiro, Shimomura, Kenju

“…Juvenile animals show higher energy intake (EI) per body weight (BW) to meet the energy requirements for growth. However, the underlying mechanisms that induce…”
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Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle by Horita, Shoichiro, Ono, Tomoyuki, Gonzalez-Resines, Saul, Ono, Yuko, Yamachi, Megumi, Zhao, Songji, Domene, Carmen, Maejima, Yuko, Shimomura, Kenju

“…Developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, the most severe end of neonatal diabetes mellitus, is caused by mutation in the…”
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Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation by Maejima, Yuko, Aoyama, Masato, Sakamoto, Kazuho, Jojima, Teruo, Aso, Yoshimasa, Takasu, Katsuya, Takenosihita, Seiichi, Shimomura, Kenju

“…Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an…”
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Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice by Zhao, Jingmin, Tan, Chengbo, Imai, Ryota, Ukon, Naoyuki, Shimoyama, Saki, Maejima, Yuko, Omiya, Yuji, Takahashi, Kazuhiro, Ito, Hiroshi, Nan, Guangxian, Zhao, Songji, Shimomura, Kenju

“…It is important to determine the functional changes of organs that occur as a result of aging, the understanding of which may lead to the maintenance of a…”
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Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus by Maejima, Yuko, Takahashi, Shinichi, Takasu, Katsuya, Takenoshita, Seiichi, Ueta, Yoichi, Shimomura, Kenju

“…Oxytocin neurons in the paraventricular nucleus (PVN) of the hypothalamus play an important role in food intake regulation. It has been shown that the…”
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Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus by Maejima, Yuko, Sakuma, Kazuya, Santoso, Putra, Gantulga, Darambazar, Katsurada, Kenichi, Ueta, Yoichi, Hiraoka, Yuichi, Nishimori, Katsuhiko, Tanaka, Shigeyasu, Shimomura, Kenju, Yada, Toshihiko

“…•Oxytocin is a new activator of ARC POMC neurons.•PVN and SON oxytocin neurons project to ARC POMC neurons.•PVN/SON to ARC POMC circuit could partly mediate…”
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Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway by Iseki, Yuzo, Ono, Yuko, Hibi, Chihiro, Tanaka, Shoko, Takeshita, Shunya, Maejima, Yuko, Kurokawa, Junko, Murakawa, Masahiro, Shimomura, Kenju, Sakamoto, Kazuho

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