A case of glomerulonephritis with singular high titer of anticardiolipin antibody

We report here a case of severe membranoproliferative glomerulonephritis with a singular high titer of anticardiolipin antibody (aCL) . A 19-year-old Japanese female was admitted to after complaining of general edema for 5 months. She had no past history of thrombosis, thrombocytopenia, or spontaneo...

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Bibliographic Details
Published in:	Nihon Jinzo Gakkai shi Vol. 40; no. 2; pp. 54 - 59
Main Authors:	HIRAYAMA, Aki, KIKUCHI, Hiroshi, HIBINO, Toshiko, KOBAYASHI, Masaki, YAMAGUCHI, Naoto, IITSUKA, Tadashi, NAGASE, Souji, AOYAGI, Kazumasa, SHIMOKAMA, Tatsurou, KOYAMA, Akio, TOJO, Shizuo
Format:	Journal Article
Language:	Japanese
Published:	Japan Japanese Society of Nephrology 1998
Subjects:	Adult Anti-Inflammatory Agents - administration & dosage Antibodies, Anticardiolipin - analysis Anticoagulants - administration & dosage antiphospholipid syndrome, anticardiolipin antibody, membranoproliferative glomerulonephritis, systemic lupus erythematosus Dipyridamole - administration & dosage Female Glomerulonephritis, Membranoproliferative - drug therapy Glomerulonephritis, Membranoproliferative - immunology Glomerulonephritis, Membranoproliferative - pathology Humans Kidney Glomerulus - pathology Methylprednisolone - administration & dosage Platelet Aggregation Inhibitors - administration & dosage Prednisolone - administration & dosage Warfarin - administration & dosage
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Summary:	We report here a case of severe membranoproliferative glomerulonephritis with a singular high titer of anticardiolipin antibody (aCL) . A 19-year-old Japanese female was admitted to after complaining of general edema for 5 months. She had no past history of thrombosis, thrombocytopenia, or spontaneous abortion. Laboratory findings revealed that she had nephrotic syndrome and moderate renal dysfunction. Immunological test showed a high titer of aCL with a high-normal limit of antinuclear antibody, negativity for anti-α2 glycoprotein I antibody and negativity for anti-DNA antibody. In the renal biopsy tissue, most glomeruli showed global sclerosis and the remaining glomeruli revealed membranoproliferative change with crescent formation. Steroid therapy with warfarin and dipyridamole was effective and her renal function improved gradually. This case lacked the typical symptoms of primary antiphospholipid syndrome and did not satisfy the criteria of SLE. In spite of these findings, the singular high titer of aCL with membranoproliferative glomerulonephritis characterized this case.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Report-3 ObjectType-Case Study-4
ISSN:	0385-2385 1884-0728
DOI:	10.14842/jpnjnephrol1959.40.54