Search Results - "SHIMAZAWA, Masamitsu"

Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light by Kuse, Yoshiki, Ogawa, Kenjiro, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hara, Hideaki

“…Our eyes are increasingly exposed to light from the emitting diode (LED) light of video display terminals (VDT) which contain much blue light. VDTs are…”
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Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage by Imai, Takahiko, Iwata, Sena, Hirayama, Tasuku, Nagasawa, Hideko, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, the detail effect of iron on blood-brain…”
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The Involvement of the Oxidative Stress in Murine Blue LED Light-Induced Retinal Damage Model by Nakamura, Maho, Kuse, Yoshiki, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hara, Hideaki

“…The aim of study was to establish a mouse model of blue light emitting diode (LED) light-induced retinal damage and to evaluate the effects of the antioxidant…”
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Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells by Otsu, Wataru, Ishida, Kodai, Chinen, Naoki, Nakamura, Shinsuke, Shimazawa, Masamitsu, Tsusaki, Hideshi, Hara, Hideaki

“…The cornea is directly exposed to cigarette smoke, and smoking is a risk factor for several corneal diseases including dry eye syndrome. Currently, heated…”
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3-Nitropropionic Acid Enhances Ferroptotic Cell Death via NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin by Okada, Noria, Nakamura, Shinsuke, Shimazawa, Masamitsu

“…Huntington’s disease (HD) is a hereditary neurodegenerative disease that involves an expansion of the CAG repeats of the Huntingtin (HTT) gene, but the disease…”
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Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation by Moriguchi, Mayu, Nakamura, Shinsuke, Inoue, Yuki, Nishinaka, Anri, Nakamura, Maho, Shimazawa, Masamitsu, Hara, Hideaki

“…To determine the mechanism causing degeneration of the retinal pigment epithelium (RPE) and photoreceptors in mice after an intravenous injection of sodium…”
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The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation by Fujimori, Honoka, Ohba, Takuya, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms and neuropathological features, such as loss of dopaminergic neurons…”
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Lipid Droplet Accumulation Promotes RPE Dysfunction by Yako, Tomohiro, Otsu, Wataru, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of…”
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Physiological Roles of Metallothioneins in Central Nervous System Diseases by Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Metallothioneins (MTs) are small-molecular weight metal-binding proteins involved in the maintenance of tissue structure, efficient metal metabolism, and metal…”
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Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy by Ando, Shiori, Osanai, Daiki, Takahashi, Kei, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…The deficiency of survival motor neuron (SMN) protein can result in the onset of spinal muscular atrophy (SMA), an autosomal recessive disorder characterized…”
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Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK by Shoda, Kenji, Tsuji, Shohei, Nakamura, Shinsuke, Egashira, Yusuke, Enomoto, Yukiko, Nakayama, Noriyuki, Shimazawa, Masamitsu, Iwama, Toru, Hara, Hideaki

“…Sodium-glucose transporter 2 (SGLT2) inhibitors are antidiabetic drugs affecting SGLT2. Recent studies have shown various cancers expressing SGLT2, and SGLT2…”
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Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure by Ishida, Kodai, Yako, Tomohiro, Tanaka, Miruto, Otsu, Wataru, Nakamura, Shinsuke, Shimazawa, Masamitsu, Tsusaki, Hideshi, Hara, Hideaki

“…The corneal epithelium is continuously exposed to oxygen, light, and environmental substances. Excessive exposure to those stresses is thought to be a risk…”
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Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells by Yako, Tomohiro, Nakamura, Maho, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu

“…Mitochondria maintain their function by the process of mitochondrial dynamics, which involves repeated fusion and fission. It is thought that the failure of…”
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Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models by Imai, Takahiko, Tsuji, Shohei, Matsubara, Hirohumi, Ohba, Takuya, Sugiyama, Tomoki, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu

“…Purpose Intracranial hemorrhage (ICH) is a devastating disease with high mortality and morbidity. After ICH, iron released from the hematoma plays a crucial…”
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A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase by Sugiyama, Tomoki, Imai, Takahiko, Nakamura, Shinsuke, Yamauchi, Keita, Sawada, Shigenobu, Shimazawa, Masamitsu, Hara, Hideaki

“…•RS9 decreased brain edema and neurological deficit after ICH.•RS9 up-regulated HO-1 and SOD-1 expression after ICH.•RS9 decreased neuronal cell death after in…”
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Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice by Takahashi, Kei, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Progranulin (PGRN) is a secreted glycoprotein that regulates numerous cellular processes. The role of PGRN as a regulator of lysosomes has recently received…”
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Piezo 1 is involved in intraocular pressure regulation by Morozumi, Wataru, Aoshima, Kota, Inagaki, Satoshi, Iwata, Yuki, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu

“…Trabecular meshwork (TM) regulates the intraocular pressure (IOP) through the control of aqueous humor outflow. Previous reports show that TM cells express 11…”
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Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin by Okada, Noria, Yako, Tomohiro, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects…”
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Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis by Yako, Tomohiro, Nakamura, Maho, Otsu, Wataru, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Aging is a predominant risk factor for various eye diseases. Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and its…”
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Progranulin deficiency in Iba-1 + myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation by Takahashi, Kei, Nakamura, Shinsuke, Otsu, Wataru, Shimazawa, Masamitsu, Hara, Hideaki

“…Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the…”
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