Search Results - "SHIMAMURA, Masahiro"
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Identification of Transporters Involved in Beraprost Sodium Transport In Vitro
Published in European journal of drug metabolism and pharmacokinetics (01-02-2017)“…Background and Objective Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial…”
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Nalfurafine hydrochloride for refractory pruritus in peritoneal dialysis patients: a phase III, multi-institutional, non-controlled, open-label trial
Published in Renal replacement therapy (01-12-2017)“…BackgroundNalfurafine hydrochloride (“nalfurafine”), the world’s first selective oral κ-receptor agonist for improving pruritus, is approved in Japan for the…”
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(3 R)-3-Amino-4-(2,4,5-trifluorophenyl)- N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Published in Bioorganic & medicinal chemistry (15-10-2008)“…Novel series of 3-amino- N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino- N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as…”
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The Pharmacokinetics of Beraprost Sodium Following Single Oral Administration to Subjects With Impaired Kidney Function
Published in Journal of clinical pharmacology (01-04-2017)“…The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS‐314d, in Japanese subjects with…”
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Differential involvement of spinal protein kinase C and protein kinase A in neuropathic and inflammatory pain in mice
Published in Brain research (05-12-2003)“…In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation…”
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