Search Results - "SHIMAMOTO, Kazuaki"

Plasma Xanthine Oxidoreductase Activity as a Novel Biomarker of Metabolic Disorders in a General Population by Furuhashi, Masato, Matsumoto, Megumi, Tanaka, Marenao, Moniwa, Norihito, Murase, Takayo, Nakamura, Takashi, Ohnishi, Hirofumi, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Miura, Tetsuji

“…Background:Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in…”
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Potential differential effects of renin-angiotensin system inhibitors on SARS-CoV-2 infection and lung injury in COVID-19 by Furuhashi, Masato, Moniwa, Norihito, Takizawa, Hideki, Ura, Nobuyuki, Shimamoto, Kazuaki

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Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1 by Tanno, Masaya, Sakamoto, Jun, Miura, Tetsuji, Shimamoto, Kazuaki, Horio, Yoshiyuki

“…Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog,…”
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Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases by Furuhashi, Masato, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Miura, Tetsuji

“…Over the past decade, evidences of an integration of metabolic and inflammatory pathways, referred to as metaflammation in several aspects of metabolic…”
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Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure by Tanno, Masaya, Kuno, Atsushi, Yano, Toshiyuki, Miura, Tetsuji, Hisahara, Shin, Ishikawa, Satoko, Shimamoto, Kazuaki, Horio, Yoshiyuki

“…Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD+-dependent histone/protein deacetylase, promotes cell survival under oxidative…”
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Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study by Saito, Norie, Furuhashi, Masato, Koyama, Masayuki, Higashiura, Yukimura, Akasaka, Hiroshi, Tanaka, Marenao, Moniwa, Norihito, Ohnishi, Hirofumi, Saitoh, Shigeyuki, Ura, Nobuyuki, Shimamoto, Kazuaki, Miura, Tetsuji

“…Fatty acid-binding protein 4 (FABP4) is secreted from adipose tissue and acts as an adipokine, and an elevated circulating FABP4 level is associated with…”
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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014) by Shimamoto, Kazuaki, Ando, Katsuyuki, Fujita, Toshiro, Hasebe, Naoyuki, Higaki, Jitsuo, Horiuchi, Masatsugu, Imai, Yutaka, Imaizumi, Tsutomu, Ishimitsu, Toshihiko, Ito, Masaaki, Ito, Sadayoshi, Itoh, Hiroshi, Iwao, Hiroshi, Kai, Hisashi, Kario, Kazuomi, Kashihara, Naoki, Kawano, Yuhei, Kim-Mitsuyama, Shokei, Kimura, Genjiro, Kohara, Katsuhiko, Komuro, Issei, Kumagai, Hiroo, Matsuura, Hideo, Miura, Katsuyuki, Morishita, Ryuichi, Naruse, Mitsuhide, Node, Koichi, Ohya, Yusuke, Rakugi, Hiromi, Saito, Ikuo, Saitoh, Shigeyuki, Shimada, Kazuyuki, Shimosawa, Tatsuo, Suzuki, Hiromichi, Tamura, Kouichi, Tanahashi, Norio, Tsuchihashi, Takuya, Uchiyama, Makoto, Ueda, Shinichiro, Umemura, Satoshi

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Circulating Fatty Acid-Binding Protein 4 Concentration Predicts the Progression of Carotid Atherosclerosis in a General Population Without Medication by Furuhashi, Masato, Yuda, Satoshi, Muranaka, Atsuko, Kawamukai, Mina, Matsumoto, Megumi, Tanaka, Marenao, Moniwa, Norihito, Ohnishi, Hirofumi, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Miura, Tetsuji

“…Background:Fatty acid-binding protein 4 (FABP4), which is expressed in both adipocytes and macrophages, is secreted from the cells and acts as an adipokine. An…”
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Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication by Furuhashi, Masato, Higashiura, Yukimura, Koyama, Masayuki, Tanaka, Marenao, Murase, Takayo, Nakamura, Takashi, Akari, Seigo, Sakai, Akiko, Mori, Kazuma, Ohnishi, Hirofumi, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Miura, Tetsuji

“…Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in purine metabolism, is involved in reactive oxygen species…”
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Local Production of Fatty Acid–Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis by Furuhashi, Masato, Fuseya, Takahiro, Murata, Masaki, Hoshina, Kyoko, Ishimura, Shutaro, Mita, Tomohiro, Watanabe, Yuki, Omori, Akina, Matsumoto, Megumi, Sugaya, Takeshi, Oikawa, Tsuyoshi, Nishida, Junichi, Kokubu, Nobuaki, Tanaka, Marenao, Moniwa, Norihito, Yoshida, Hideaki, Sawada, Norimasa, Shimamoto, Kazuaki, Miura, Tetsuji

“…OBJECTIVE—Fatty acid–binding protein 4 (FABP4) is expressed in adipocytes and macrophages, and elevated circulating FABP4 level is associated with…”
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Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy by Hori, Yusuke S, Kuno, Atsushi, Hosoda, Ryusuke, Tanno, Masaya, Miura, Tetsuji, Shimamoto, Kazuaki, Horio, Yoshiyuki

“…Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. We previously showed that…”
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Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals by Tanaka, Marenao, Takahashi, Satoko, Higashiura, Yukimura, Sakai, Akiko, Koyama, Masayuki, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Ohnishi, Hirofumi, Furuhashi, Masato

“…ABSTRACT Aims/Introduction Metabolic dysfunction‐associated fatty liver disease (MAFLD), defined as hepatosteatosis with type 2 diabetes mellitus,…”
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Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication by Furuhashi, Masato, Kataoka, Yu, Nishikawa, Ryo, Koyama, Masayuki, Sakai, Akiko, Higashiura, Yukimura, Tanaka, Marenao, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Ohnishi, Hirofumi

“…Aim: Dyslipidemia and altered iron metabolism are typical features of non-alcoholic fatty liver disease (NAFLD). Proprotein convertase subtilisin/kexin type 7…”
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Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population by Furuhashi, Masato, Sakai, Akiko, Tanaka, Marenao, Higashiura, Yukimura, Mori, Kazuma, Koyama, Masayuki, Ohnishi, Hirofumi, Saitoh, Shigeyuki, Shimamoto, Kazuaki

“…Severe acute respiratory syndrome coronavirus 2 in coronavirus disease 2019 invades the host through ACE (angiotensin-converting enzyme) 2 as the host cellular…”
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Differential regulation of hypoxanthine and xanthine by obesity in a general population by Furuhashi, Masato, Koyama, Masayuki, Higashiura, Yukimura, Murase, Takayo, Nakamura, Takashi, Matsumoto, Megumi, Sakai, Akiko, Ohnishi, Hirofumi, Tanaka, Marenao, Saitoh, Shigeyuki, Moniwa, Norihito, Shimamoto, Kazuaki, Miura, Tetsuji

“…Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a…”
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Genome-wide association study of coronary artery disease in the Japanese by TAKEUCHI, Fumihiko, YOKOTA, Mitsuhiro, AWATA, Nobuhisa, OHNAKA, Keizo, NAKATOCHI, Masahiro, KITAJIMA, Hidetoshi, RAKUGI, Hiromi, NAKAMURA, Jiro, OHKUBO, Takayoshi, IMAI, Yutaka, SHIMAMOTO, Kazuaki, YAMORI, Yukio, YAMAMOTO, Ken, YAMAGUCHI, Shuhei, KOBAYASHI, Shotai, TAKAYANAGI, Ryoichi, OGIHARA, Toshio, KATO, Norihiro, NAKASHIMA, Eitaro, KATSUYA, Tomohiro, ASANO, Hiroyuki, ISONO, Masato, NABIKA, Toru, SUGIYAMA, Takao, FUJIOKA, Akihiro

“…A new understanding of the genetic basis of coronary artery disease (CAD) has recently emerged from genome-wide association (GWA) studies of common…”
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Estimated daily intake and seasonal food sources of quercetin in Japan by Nishimuro, Haruno, Ohnishi, Hirofumi, Sato, Midori, Ohnishi-Kameyama, Mayumi, Matsunaga, Izumi, Naito, Shigehiro, Ippoushi, Katsunari, Oike, Hideaki, Nagata, Tadahiro, Akasaka, Hiroshi, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Kobori, Masuko

“…Quercetin is a promising food component, which can prevent lifestyle related diseases. To understand the dietary intake of quercetin in the subjects of a…”
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Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance by Kawamori, Ryuzo, Prof, Tajima, Naoko, Prof, Iwamoto, Yasuhiko, Prof, Kashiwagi, Atsunori, Prof, Shimamoto, Kazuaki, Prof, Kaku, Kohei, Prof

“…Summary Background The increased prevalence of type 2 diabetes mellitus is a major concern for health providers. We therefore assessed whether voglibose, an…”
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FABP4 is secreted from adipocytes by adenyl cyclase‐PKA‐ and guanylyl cyclase‐PKG‐dependent lipolytic mechanisms by Mita, Tomohiro, Furuhashi, Masato, Hiramitsu, Shinya, Ishii, Junnichi, Hoshina, Kyoko, Ishimura, Shutaro, Fuseya, Takahiro, Watanabe, Yuki, Tanaka, Marenao, Ohno, Kohei, Akasaka, Hiroshi, Ohnishi, Hirofumi, Yoshida, Hideaki, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Miura, Tetsuji

“…Objective Fatty acid‐binding protein 4 (FABP4) is expressed in adipocytes, and elevated plasma FABP4 level is associated with obesity‐mediated metabolic…”
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Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein[S] by Kuno, Atsushi, Hori, Yusuke S., Hosoda, Ryusuke, Tanno, Masaya, Miura, Tetsuji, Shimamoto, Kazuaki, Horio, Yoshiyuki

“…Cardiomyopathy is the main cause of death in Duchenne muscular dystrophy. Here, we show that oral administration of resveratrol, which leads to activation of…”
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