Search Results - "SHIMADA, Kenichi"

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis by Shimada, Kenichi, Skouta, Rachid, Kaplan, Anna, Yang, Wan Seok, Hayano, Miki, Dixon, Scott J, Brown, Lewis M, Valenzuela, Carlos A, Wolpaw, Adam J, Stockwell, Brent R

“…Editorial Summary Modulatory profiling of lethal small-molecule compounds identified FIN56 as an inducer of ferroptosis. FIN56 promotes the degradation of…”
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shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data by Shimada, Kenichi, Bachman, John A, Muhlich, Jeremy L, Mitchison, Timothy J

“…Individual cancers rely on distinct essential genes for their survival. The Cancer Dependency Map (DepMap) is an ongoing project to uncover these gene…”
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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models by Skouta, Rachid, Dixon, Scott J, Wang, Jianlin, Dunn, Denise E, Orman, Marina, Shimada, Kenichi, Rosenberg, Paul A, Lo, Donald C, Weinberg, Joel M, Linkermann, Andreas, Stockwell, Brent R

“…Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular…”
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Regulation of Ferroptotic Cancer Cell Death by GPX4 by Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.

“…Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12…”
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Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis by Tumurkhuu, Gantsetseg, Shimada, Kenichi, Dagvadorj, Jargalsaikhan, Crother, Timothy R, Zhang, Wenxuan, Luthringer, Daniel, Gottlieb, Roberta A, Chen, Shuang, Arditi, Moshe

“…RATIONALE:Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome-mediating interleukin (IL)-1β…”
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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis by Shimada, Kenichi, Crother, Timothy R., Karlin, Justin, Dagvadorj, Jargalsaikhan, Chiba, Norika, Chen, Shuang, Ramanujan, V. Krishnan, Wolf, Andrea J., Vergnes, Laurent, Ojcius, David M., Rentsendorj, Altan, Vargas, Mario, Guerrero, Candace, Wang, Yinsheng, Fitzgerald, Katherine A., Underhill, David M., Town, Terrence, Arditi, Moshe

“…We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of…”
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Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation by Noval Rivas, Magali, Wakita, Daiko, Franklin, Michael K., Carvalho, Thacyana T., Abolhesn, Amanda, Gomez, Angela C., Fishbein, Michael C., Chen, Shuang, Lehman, Thomas J., Sato, Kazuki, Shibuya, Akira, Fasano, Alessio, Kiyono, Hiroshi, Abe, Masanori, Tatsumoto, Narihito, Yamashita, Michifumi, Crother, Timothy R., Shimada, Kenichi, Arditi, Moshe

“…Recent experimental data and clinical, genetic, and transcriptome evidence from patients converge to suggest a key role of interleukin-1β (IL-1β) in the…”
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Unsupervised identification of disease states from high‐dimensional physiological and histopathological profiles by Shimada, Kenichi, Mitchison, Timothy J

“…The liver and kidney in mammals play central roles in protecting the organism from xenobiotics and are at high risk of xenobiotic‐induced injury…”
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NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis by Porritt, Rebecca A., Zemmour, David, Abe, Masanori, Lee, Youngho, Narayanan, Meena, Carvalho, Thacyana T., Gomez, Angela C., Martinon, Daisy, Santiskulvong, Chintda, Fishbein, Michael C., Chen, Shuang, Crother, Timothy R., Shimada, Kenichi, Arditi, Moshe, Noval Rivas, Magali

“…[Figure: see text]…”
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Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis by Onat, Umut I., Yildirim, Asli D., Tufanli, Özlem, Çimen, Ismail, Kocatürk, Begüm, Veli, Zehra, Hamid, Syed M., Shimada, Kenichi, Chen, Shuang, Sin, Jon, Shah, Prediman K., Gottlieb, Roberta A., Arditi, Moshe, Erbay, Ebru

“…Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the…”
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Correlation between noise pareidolia test scores for visual hallucinations and regional cerebral blood flow in dementia with Lewy bodies by Nakata, Takashi, Shimada, Kenichi, Iba, Akiko, Oda, Haruhiko, Terashima, Akira, Koide, Yutaka, Kawasaki, Ryota, Yamada, Takahiro, Ishii, Kazunari

“…Objective This study aimed at investigating the correlation between recurrent visual hallucinations (VHs) and regional cerebral blood flow (rCBF) in patients…”
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Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury by Nosaka, Nobuyuki, Martinon, Daisy, Moreira, Debbie, Crother, Timothy R, Arditi, Moshe, Shimada, Kenichi

“…Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and…”
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Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells by Nakanishi, Mio, Mitchell, Ryan R., Benoit, Yannick D., Orlando, Luca, Reid, Jennifer C., Shimada, Kenichi, Davidson, Kathryn C., Shapovalova, Zoya, Collins, Tony J., Nagy, Andras, Bhatia, Mickie

“…The assembly of organized colonies is the earliest manifestation in the derivation or induction of pluripotency in vitro. However, the necessity and origin of…”
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The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury by Jones, Heather D, Crother, Timothy R, Gonzalez-Villalobos, Romer A, Jupelli, Madhulika, Chen, Shuang, Dagvadorj, Jargalsaikhan, Arditi, Moshe, Shimada, Kenichi

“…IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and…”
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Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic Aneurysm by Wakita, Daiko, Kurashima, Yosuke, Crother, Timothy R, Noval Rivas, Magali, Lee, Youngho, Chen, Shuang, Fury, Wen, Bai, Yu, Wagner, Shawn, Li, Debiao, Lehman, Thomas, Fishbein, Michael C, Hoffman, Hal M, Shah, Prediman K, Shimada, Kenichi, Arditi, Moshe

“…OBJECTIVE—Kawasaki disease (KD) is the most common cause of acquired cardiac disease in US children. In addition to coronary artery abnormalities and…”
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Potential Fast COVID-19 Containment With Trehalose by Martinon, Daisy, Borges, Vanessa F., Gomez, Angela C., Shimada, Kenichi

“…Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection…”
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Treatment for Calcaneal Osteomyelitis with Pseudoarthrosis with a Vascularized Fibula Bone Graft and Autologous Cancellous Bone Graft: A Case Report by Miyanaga, Toru, Kaneko, Takayoshi, Yagishita, Mikio, Kishibe, Miyuki, Yamashita, Masanobu, Shimada, Kenichi

“…Calcaneal osteomyelitis with pseudarthrosis after calcaneal fracture is rare, and its treatment is challenging. We describe the use of a free fibular…”
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IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice by Chen, Shuang, Shimada, Kenichi, Zhang, Wenxuan, Huang, Ganghua, Crother, Timothy R, Arditi, Moshe

“…The role of IL-17 in atherogenesis remains controversial. We previously reported that the TLR/MyD88 signaling pathway plays an important role in high-fat diet…”
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Modulatory profiling identifies mechanisms of small molecule-induced cell death by Wolpaw, Adam J., Shimada, Kenichi, Skouta, Rachid, Welsch, Matthew E., Akavia, Uri David, Pe'er, Dana, Shaik, Fatima, Bulinski, J. Chloe, Stockwell, Brent R.

“…Cell death is a complex process that plays a vital role in development, homeostasis, and disease. Our understanding of and ability to control cell death is…”
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Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus by Ishii, Kazunari, Kanda, Tomonori, Harada, Aya, Miyamoto, Naokazu, Kawaguchi, Tetsuro, Shimada, Kenichi, Ohkawa, Shingo, Uemura, Takafumi, Yoshikawa, Toshiki, Mori, Etsuro

“…The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated…”
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