Search Results - "SHIKATA, Kenichi"

Recent evidence in the etiology and treatment for diabetic kidney disease by Shikata, Kenichi

“…Etiology and therapeutic targets of diabetic nephropathy…”
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Efficacy and safety of esaxerenone (CS-3150) in Japanese patients with type 2 diabetes and macroalbuminuria: a multicenter, single-arm, open-label phase III study by Ito, Sadayoshi, Kashihara, Naoki, Shikata, Kenichi, Nangaku, Masaomi, Wada, Takashi, Okuda, Yasuyuki, Sawanobori, Tomoko

“…Background Esaxerenone has potential renoprotective effects and reduces the urinary albumin-to-creatinine ratio (UACR) in patients with diabetic kidney disease…”
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The renoprotective effect of esaxerenone independent of blood pressure lowering: a post hoc mediation analysis of the ESAX-DN trial by Okuda, Yasuyuki, Ito, Sadayoshi, Kashihara, Naoki, Shikata, Kenichi, Nangaku, Masaomi, Wada, Takashi, Sawanobori, Tomoko, Taguri, Masataka

“…Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) are recommended as first-line drugs for hypertension with diabetic…”
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Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK‐Ay mice by Oda, Kaori, Miyamoto, Satoshi, Kodera, Ryo, Wada, Jun, Shikata, Kenichi

“…Aims/Introduction Nucleotide‐binding oligomerization domain‐like receptor family pyrin domain containing 3 (NLRP3) inflammasomes produce IL‐18 upon being…”
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Microinflammation in the pathogenesis of diabetic nephropathy by Shikata, Kenichi, Makino, Hirofumi

“…Diabetic nephropathy is the leading cause of end‐stage renal failure in developed countries. Furthermore, diabetic nephropathy is related to the risk of…”
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Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis by Nojima, Ichiro, Eikawa, Shingo, Tomonobu, Nahoko, Hada, Yoshiko, Kajitani, Nobuo, Teshigawara, Sanae, Miyamoto, Satoshi, Tone, Atsuhito, Uchida, Haruhito A., Nakatsuka, Atsuko, Eguchi, Jun, Shikata, Kenichi, Udono, Heiichiro, Wada, Jun

“…The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In…”
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Reduction in the magnitude of serum potassium elevation in combination therapy with esaxerenone (CS‐3150) and sodium–glucose cotransporter 2 inhibitor in patients with diabetic kidney disease: Subanalysis of two phase III studies by Shikata, Kenichi, Ito, Sadayoshi, Kashihara, Naoki, Nangaku, Masaomi, Wada, Takashi, Okuda, Yasuyuki, Sawanobori, Tomoko, Sugimoto, Kotaro

“…Aims/Introduction We evaluated the effect of co‐administration of esaxerenone and a sodium–glucose cotransporter 2 (SGLT2) inhibitor on the magnitude of serum…”
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Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 5 by Shikata, Kenichi, Kodera, Ryo, Utsunomiya, Kazunori, Koya, Daisuke, Nishimura, Rimei, Miyamoto, Satoshi, Tajima, Naoko

“…Aims/Introduction To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the…”
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Randomized trial of an intensified, multifactorial intervention in patients with advanced‐stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) by Shikata, Kenichi, Haneda, Masakazu, Ninomiya, Toshiharu, Koya, Daisuke, Suzuki, Yoshiki, Suzuki, Daisuke, Ishida, Hitoshi, Akai, Hiroaki, Tomino, Yasuhiko, Uzu, Takashi, Nishimura, Motonobu, Maeda, Shiro, Ogawa, Daisuke, Miyamoto, Satoshi, Makino, Hirofumi

“…Aims/Introduction We evaluated the efficacy of multifactorial intensive treatment (IT) on renal outcomes in patients with type 2 diabetes and advanced‐stage…”
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Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity by Hida, K, Wada, J, Eguchi, J, Zhang, H, Baba, M, Seida, A, Hashimoto, I, Okada, T, Yasuhara, A, Nakatsuka, A

“…There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as…”
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Edaravone Attenuated Angiotensin II-Induced Atherosclerosis and Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice by Uchida, Haruhito A, Takatsuka, Tetsuharu, Hada, Yoshiko, Umebayashi, Ryoko, Takeuchi, Hidemi, Shikata, Kenichi, Subramanian, Venkateswaran, Daugherty, Alan, Wada, Jun

“…Background: The aim of the study was to define whether edaravone, a free-radical scavenger, influenced angiotensin II (AngII)-induced atherosclerosis and…”
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Impact of Amino Acids Nutrition Following Gastrectomy in Gastric Cancer Patients by Kikuchi, Satoru, Takata, Nobuo, Kuroda, Shinji, Umeda, Hibiki, Tanabe, Shunsuke, Maeda, Naoaki, Takagi, Kosei, Noma, Kazuhiro, Hasegawa, Yuko, Nawachi, Kumiko, Kagawa, Shunsuke, Umeda, Yuzo, Shikata, Kenichi, Fujiwara, Toshiyoshi

“…Background/Aim: Postoperative body weight loss (BWL) and skeletal muscle loss (SML) after gastrectomy are associated with a decline in quality of life and…”
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Renoprotective effects of incretin‐based drugs: A novel pleiotropic effect of dipeptidyl peptidase‐4 inhibitor by Kodera, Ryo, Shikata, Kenichi

“…Renoprotective effects of incretin‐based drug…”
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Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease by Ohmoto, Yasukazu, Shikata, Kenichi, Wada, Jun, Kano, Yuzuki, Ogawa-Akiyama, Ayu, Onishi, Akifumi, Kitagawa, Masashi, Morinaga, Hiroshi, Tanaka, Keiko, Sugiyama, Hitoshi, Yamanari, Toshio, Mise, Koki

“…Introduction. Trefoil factor family (TFF) peptides are increased in serum and urine in patients with chronic kidney disease (CKD). However, whether the levels…”
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Activation of Liver X Receptor Inhibits Osteopontin and Ameliorates Diabetic Nephropathy by TACHIBANA, Hiromi, OGAWA, Daisuke, MAKINO, Hirofumi, MATSUSHITA, Yuichi, BRUEMMER, Dennis, WADA, Jun, TESHIGAWARA, Sanae, EGUCHI, Jun, SATO-HORIGUCHI, Chikage, ADAM UCHIDA, Haruhito, SHIKATA, Kenichi

“…Osteopontin is a proinflammatory cytokine and monocyte chemoattractant implicated in the pathogenesis of diabetic nephropathy. Synthetic agonists for liver X…”
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The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study by Katayama, Akihiro, Tone, Atsuhito, Watanabe, Mayu, Teshigawara, Sanae, Miyamoto, Satoshi, Eguchi, Jun, Nakatsuka, Atsuko, Shikata, Kenichi, Wada, Jun

“…Aims/introduction The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the…”
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The Glucose-lowering Efficacy of Sitagliptin in Obese Japanese Patients with Type 2 Diabetes by Kodera, Ryo, Shikata, Kenichi, Nakamura, Akihiko, Okazaki, Satoru, Nagase, Ryo, Nakatou, Tatsuaki, Haisa, Shigeru, Hida, Kazuyuki, Miyashita, Katsuhiro, Makino, Hirofumi

“…Objective Dipeptidyl peptidase-4 (DPP-4) inhibitors are the most frequently prescribed oral hypoglycemic agents in Japan. Although a relationship between the…”
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Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes by OKADA, Shinichi, SHIKATA, Kenichi, MATSUDA, Mitsuhiro, OGAWA, Daisuke, USUI, Hitomi, KIDO, Yuichi, NAGASE, Ryo, WADA, Jun, SHIKATA, Yasushi, MAKINO, Hirofumi

“…Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes Shinichi Okada , Kenichi Shikata , Mitsuhiro…”
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Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes by Nakamura, Akihiko, Shikata, Kenichi, Hiramatsu, Makoto, Nakatou, Tatsuaki, Kitamura, Takuya, Wada, Jun, Itoshima, Tatsuya, Makino, Hirofumi

“…OBJECTIVE:--Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in…”
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The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study by Matsuoka-Uchiyama, Natsumi, Uchida, Haruhito A., Okamoto, Shugo, Onishi, Yasuhiro, Katayama, Katsuyoshi, Tsuchida-Nishiwaki, Mariko, Takeuchi, Hidemi, Takemoto, Rika, Hada, Yoshiko, Umebayashi, Ryoko, Kurooka, Naoko, Tsuji, Kenji, Eguchi, Jun, Nakajima, Hirofumi, Shikata, Kenichi, Wada, Jun

“…Objective. We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation…”
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