Search Results - "SHIH, Alan H"

The role of mutations in epigenetic regulators in myeloid malignancies by Shih, Alan H., Abdel-Wahab, Omar, Patel, Jay P., Levine, Ross L.

“…Key Points Mutations in epigenetic modifiers account for new classes of mutant disease alleles that contribute to the pathogenesis of myeloid malignancies in…”
Get full text

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations by Han, Dali, Lu, Xingyu, Shih, Alan H., Nie, Ji, You, Qiancheng, Xu, Meng Michelle, Melnick, Ari M., Levine, Ross L., He, Chuan

“…We present a highly sensitive and selective chemical labeling and capture approach for genome-wide profiling of 5-hydroxylmethylcytosine (5hmC) using DNA…”
Get full text

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression by Abdel-Wahab, Omar, Adli, Mazhar, LaFave, Lindsay M., Gao, Jie, Hricik, Todd, Shih, Alan H., Pandey, Suveg, Patel, Jay P., Chung, Young Rock, Koche, Richard, Perna, Fabiana, Zhao, Xinyang, Taylor, Jordan E., Park, Christopher Y., Carroll, Martin, Melnick, Ari, Nimer, Stephen D., Jaffe, Jacob D., Aifantis, Iannis, Bernstein, Bradley E., Levine, Ross L.

“…Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated…”
Get full text

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia by Shih, Alan H., Jiang, Yanwen, Meydan, Cem, Shank, Kaitlyn, Pandey, Suveg, Barreyro, Laura, Antony-Debre, Ileana, Viale, Agnes, Socci, Nicholas, Sun, Yongming, Robertson, Alexander, Cavatore, Magali, de Stanchina, Elisa, Hricik, Todd, Rapaport, Franck, Woods, Brittany, Wei, Chen, Hatlen, Megan, Baljevic, Muhamed, Nimer, Stephen D., Tallman, Martin, Paietta, Elisabeth, Cimmino, Luisa, Aifantis, Iannis, Steidl, Ulrich, Mason, Chris, Melnick, Ari, Levine, Ross L.

“…Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and TET2 mutations, confer distinct biologic features and adverse…”
Get full text

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS by Deplus, Rachel, Delatte, Benjamin, Schwinn, Marie K, Defrance, Matthieu, Méndez, Jacqui, Murphy, Nancy, Dawson, Mark A, Volkmar, Michael, Putmans, Pascale, Calonne, Emilie, Shih, Alan H, Levine, Ross L, Bernard, Olivier, Mercher, Thomas, Solary, Eric, Urh, Marjeta, Daniels, Danette L, Fuks, François

“…TET proteins convert 5‐methylcytosine to 5‐hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has…”
Get full text

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo by Abdel-Wahab, Omar, Gao, Jie, Adli, Mazhar, Dey, Anwesha, Trimarchi, Thomas, Chung, Young Rock, Kuscu, Cem, Hricik, Todd, Ndiaye-Lobry, Delphine, Lafave, Lindsay M, Koche, Richard, Shih, Alan H, Guryanova, Olga A, Kim, Eunhee, Li, Sheng, Pandey, Suveg, Shin, Joseph Y, Telis, Leon, Liu, Jinfeng, Bhatt, Parva K, Monette, Sebastien, Zhao, Xinyang, Mason, Christopher E, Park, Christopher Y, Bernstein, Bradley E, Aifantis, Iannis, Levine, Ross L

“…Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10-30% of patients with myeloid malignancies, most commonly in myelodysplastic syndromes…”
Get full text

Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis by Madzo, Jozef, Liu, Hui, Rodriguez, Alexis, Vasanthakumar, Aparna, Sundaravel, Sriram, Caces, Donne Bennett D., Looney, Timothy J., Zhang, Li, Lepore, Janet B., Macrae, Trisha, Duszynski, Robert, Shih, Alan H., Song, Chun-Xiao, Yu, Miao, Yu, Yiting, Grossman, Robert, Raumann, Brigitte, Verma, Amit, He, Chuan, Levine, Ross L., Lavelle, Don, Lahn, Bruce T., Wickrema, Amittha, Godley, Lucy A.

“…Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. Identification of…”
Get full text

Notch Signaling Enhances Nestin Expression in Gliomas by Shih, Alan H., Holland, Eric C.

“…Recent findings suggest that Notch signaling is active in brain tumors and stem cells, and that stem cells or cells with progenitor characteristics contribute…”
Get full text

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia by Shih, Alan H, Chung, Stephen S, Dolezal, Emily K, Zhang, Su-Jiang, Abdel-Wahab, Omar I, Park, Christopher Y, Nimer, Stephen D, Levine, Ross L, Klimek, Virginia M

“…Therapy-related myelodysplastic syndromes and acute myelogenous leukemia comprise a poor-risk subset of myelodysplastic syndromes and acute myelogenous…”
Get full text

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML by Duy, Cihangir, Teater, Matt, Garrett-Bakelman, Francine E, Lee, Tak C, Meydan, Cem, Glass, Jacob L, Li, Meng, Hellmuth, Johannes C, Mohammad, Helai P, Smitheman, Kimberly N, Shih, Alan H, Abdel-Wahab, Omar, Tallman, Martin S, Guzman, Monica L, Muench, David, Grimes, H Leighton, Roboz, Gail J, Kruger, Ryan G, Creasy, Caretha L, Paietta, Elisabeth M, Levine, Ross L, Carroll, Martin, Melnick, Ari M

“…Disruption of epigenetic regulation is a hallmark of acute myeloid leukemia (AML), but epigenetic therapy is complicated by the complexity of the epigenome…”
Get more information

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells by Kunimoto, Hiroyoshi, McKenney, Anna Sophia, Meydan, Cem, Shank, Kaitlyn, Nazir, Abbas, Rapaport, Franck, Durham, Benjamin, Garrett-Bakelman, Francine E., Pronier, Elodie, Shih, Alan H., Melnick, Ari, Chaudhuri, Jayanta, Levine, Ross L.

“…Recent studies have reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (TET) family members regulate active DNA…”
Get full text

Safety and Efficacy: Clinical Experience of Venetoclax in Combination With Hypomethylating Agents in Both Newly Diagnosed and Relapsed/Refractory Advanced Myeloid Malignancies by Feld, Jonathan, Tremblay, Douglas, Dougherty, Mikaela, Czaplinska, Tina, Sanchez, Gillian, Brady, Claudia, Kremyanskaya, Marina, Bar‐Natan, Michal, Keyzner, Alla, Marcellino, Bridget K., Gabrilove, Janice, Navada, Shyamala C., Silverman, Lewis R., El Jamal, Siraj M., Mascarenhas, John, Shih, Alan H.

“…Hypomethylating agents (HMAs) in combination with venetoclax have been widely adopted as the standard of care for patients who cannot tolerate induction…”
Get full text

IDH1 Mutations Disrupt Blood, Brain, and Barriers by Shih, Alan H., Levine, Ross L.

“…The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone…”
Get full text

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles by Hatlen, Megan A, Arora, Kanika, Vacic, Vladimir, Grabowska, Ewa A, Liao, Willey, Riley-Gillis, Bridget, Oschwald, Dayna M, Wang, Lan, Joergens, Jacob E, Shih, Alan H, Rapaport, Franck, Gu, Shengqing, Voza, Francesca, Asai, Takashi, Neel, Benjamin G, Kharas, Michael G, Gonen, Mithat, Levine, Ross L, Nimer, Stephen D

“…t(8;21) is one of the most frequent chromosomal abnormalities observed in acute myeloid leukemia (AML). However, expression of AML1-ETO is not sufficient to…”
Get full text

Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01 by LASSMAN, Andrew B, ROSSI, Michael R, WILSON, Richard, NOWAK, Norma J, COWELL, John K, DEANGELIS, Lisa M, WEN, Patrick, GILBERT, Mark R, CHANG, Susan, YUNG, W. A, PRADOS, Michael, HOLLAND, Eric C, RAZIER, Jeffrey R, ABREY, Lauren E, LIEBERMAN, Frank S, GREFE, Chelsea N, LAMBORN, Kathleen, PAO, William, SHIH, Alan H, KUHN, John G

“…Purpose: We investigated the molecular effect of the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib in vivo on all available tumors…”
Get full text

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis by SHIH, Alan H, CHENGKAI DAI, XIAOYI HU, ROSENBLUM, Marc K, KOUTCHER, Jason A, HOLLAND, Eric C

“…Platelet-derived growth factor (PDGF) is expressed in many different tumors, but its precise roles in tumorigenesis remain to be fully defined. Here, we report…”
Get full text

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms by Meyer, Sara C., Keller, Matthew D., Chiu, Sophia, Koppikar, Priya, Guryanova, Olga A., Rapaport, Franck, Xu, Ke, Manova, Katia, Pankov, Dmitry, O’Reilly, Richard J., Kleppe, Maria, McKenney, Anna Sophia, Shih, Alan H., Shank, Kaitlyn, Ahn, Jihae, Papalexi, Eftymia, Spitzer, Barbara, Socci, Nick, Viale, Agnes, Mandon, Emeline, Ebel, Nicolas, Andraos, Rita, Rubert, Joëlle, Dammassa, Ernesta, Romanet, Vincent, Dölemeyer, Arno, Zender, Michael, Heinlein, Melanie, Rampal, Raajit, Weinberg, Rona Singer, Hoffman, Ronald, Sellers, William R., Hofmann, Francesco, Murakami, Masato, Baffert, Fabienne, Gaul, Christoph, Radimerski, Thomas, Levine, Ross L.

“…Although clinically tested JAK inhibitors reduce splenomegaly and systemic symptoms, molecular responses are not observed in most myeloproliferative neoplasm…”
Get full text

Murine Modeling of Myeloproliferative Neoplasms by Chen, Karie, Shih, Alan H.

“…Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are bone marrow disorders that result in the…”
Get full text

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations by Intlekofer, Andrew M., Shih, Alan H., Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S., Albanese, Steven K., Patel, Minal, Famulare, Christopher, Correa, Fabian M., Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R., Tallman, Martin S., Arcila, Maria E., Roshal, Mikhail, Petsko, Gregory A., Wu, Bin, Choe, Sung, Konteatis, Zenon D., Biller, Scott A., Chodera, John D., Thompson, Craig B., Levine, Ross L., Stein, Eytan M.

“…Somatic mutations in the isocitrate dehydrogenase 2 gene ( IDH2 ) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the…”
Get full text

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity by Kunimoto, Hiroyoshi, Meydan, Cem, Nazir, Abbas, Whitfield, Justin, Shank, Kaitlyn, Rapaport, Franck, Maher, Rebecca, Pronier, Elodie, Meyer, Sara C., Garrett-Bakelman, Francine E., Tallman, Martin, Melnick, Ari, Levine, Ross L., Shih, Alan H.

“…Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies, including TET2 and NRAS mutations. Concurrent Tet2 loss and…”
Get full text