Search Results - "SHIFFMAN, M. L"

Clinical trial: the efficacy and safety of oral PF‐03491390, a pancaspase inhibitor – a randomized placebo‐controlled study in patients with chronic hepatitis C by SHIFFMAN, M. L., POCKROS, P., MCHUTCHISON, J. G., SCHIFF, E. R., MORRIS, M., BURGESS, G.

“…Aliment Pharmacol Ther 31, 969–978 Summary Background  Elevated serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) reflect…”
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Histological benefits of virological response to peginterferon alfa‐2a monotherapy in patients with hepatitis C and advanced fibrosis or compensated cirrhosis by EVERSON, G. T., BALART, L., LEE, S. S., REINDOLLAR, R. W., SHIFFMAN, M. L., MINUK, G. Y., POCKROS, P. J., GOVINDARAJAN, S., LENTZ, E., HEATHCOTE, E. J.

“…Summary Background  Patients with chronic hepatitis C virus and advanced fibrosis or cirrhosis are at risk for disease progression and hepatic decompensation…”
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Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C by McHutchison, John G, Gordon, Stuart C, Schiff, Eugene R, Shiffman, Mitchell L, Lee, William M, Rustgi, Vinod K, Goodman, Zachary D, Ling, Mei-Hsiu, Cort, Susannah, Albrecht, Janice K

“…Chronic hepatitis C infection is now recognized as an important health care problem. 1 Nearly 4 million Americans are estimated to be infected, and cirrhosis…”
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Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C by Davis, Gary L, Esteban-Mur, Rafael, Rustgi, Vinod, Hoefs, John, Gordon, Stuart C, Trepo, Christian, Shiffman, Mitchell L, Zeuzem, Stefan, Craxi, Antonio, Ling, Mei-Hsiu, Albrecht, Janice

“…Nearly 4 million people in the United States and 100 million worldwide are infected with the hepatitis C virus (HCV). 1 Of these, approximately 70 percent have…”
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A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia by Shiffman, Mitchell L., Hofmann, Charlotte M., Contos, Melissa J., Luketic, Velimir A., Sanyal, Arun J., Sterling, Richard K., Ferreira-Gonzalez, Andrea, Mills, A.Scott, Garret, Carlton

“…Background & Aims: At least half of patients with chronic hepatitis C virus (HCV) fail to respond to interferon or interferon/ribavirin therapy. Histological…”
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The natural history of portal hypertension after transjugular intrahepatic portosystemic shunts by Sanyal, AJ, Freedman, AM, Luketic, VA, Purdum, PP, Shiffman, ML, DeMeo, J, Cole, PE, Tisnado, J

“…BACKGROUND & AIMS: The effects of transjugular intrahepatic portosystemic shunt (TIPS) on portal hemodynamics, esophageal and gastric varices, and hepatic…”
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Review article: management of patients with chronic hepatitis C virus infection and ‘normal’ alanine aminotransferase activity by ZEUZEM, S., ALBERTI, A., ROSENBERG, W., MARCELLIN, P., DIAGO, M., NEGRO, F., PRATI, D., PUOTI, C., ROBERTS, S. K., SHIFFMAN, M. L.

“…Summary Background Hepatitis C virus infection, a major cause of chronic liver disease, occurs with normal serum alanine aminotransferase activity in…”
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Quantitative tests of liver function measure hepatic improvement after sustained virological response: results from the HALT‐C trial by EVERSON, G. T., SHIFFMAN, M. L., HOEFS, J. C., MORGAN, T. R., STERLING, R. K., WAGNER, D. A., DESANTO, J. L., CURTO, T. M., WRIGHT, E. C.

“…Summary Backgroud  The impact of virologic response on hepatic function has not been previously defined. Aim  To determine the relationships of quantitative…”
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Right lobe living donor liver transplantation by MARCOS, A, FISHER, R. A, HAM, J. M, SHIFFMAN, M. L, SANYAL, A. J, LUKETIC, V. A. C, STERLING, R. K, POSNER, M. P

“…The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral…”
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Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation by MARCOS, A, FISHER, R. A, HAM, J. M, SHIFFMAN, M. L, SANYAL, A. J, LUKETIC, V. A. C, STERLING, R. K, FULCHER, A. S, POSNER, M. P

“…Regeneration of the liver to a predetermined size after resection or transplantation is a well described phenomenon, but the time course over which these…”
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Liver and Intestine Transplantation in the United States, 1995–2004 by Shiffman, M. L., Saab, S., Feng, S., Abecassis, M. I., Tzakis, A. G., Goodrich, N. P., Schaubel, D. E.

“…Three years of survival data are now available and the impact of the model for end‐stage liver disease (MELD) allocation system is becoming clear. After a…”
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Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy by Sanyal, AJ, Freedman, AM, Luketic, VA, Purdum, PP, Shiffman, ML, Tisnado, J, Cole, PE

“…BACKGROUND & AIMS: Despite urgent sclerotherapy, active variceal hemorrhage has a 70%-90% mortality rate in patients with advanced age, sepsis, renal or…”
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A prospective, randomized‐controlled pilot study of ursodeoxycholic acid combined with mycophenolate mofetil in the treatment of primary sclerosing cholangitis by Sterling, R. K., Salvatori, J. J., Luketic, V. A., Sanyal, A. J., Fulcher, A. S., Stravitz, R. T., Contos, M. J., Mills, A. S., Shiffman, M. L.

“…Summary Background : Ursodeoxycholic acid has been ineffective in the treatment of primary sclerosing cholangitis. Because the pathogenesis of primary…”
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Selection and outcome of living donors for adult to adult right lobe transplantation by MARCOS, A, FISHER, R. A, HAM, J. M, OLZINSKI, A. T, SHIFFMAN, M. L, SANYAL, A. J, LUKETIC, V. A. C, STERLING, R. K, OLBRISCH, M. E, POSNER, M. P

“…The shortage of cadaveric livers has sparked an interest in adult-to-adult living donor transplantation. Right lobe donor hepatectomy is frequently required to…”
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The spectrum of hepatic functional impairment in compensated chronic hepatitis C : results from the Hepatitis C Anti-viral Long-term Treatment against Cirrhosis Trial by EVERSON, G. T, SHIFFMAN, M. L, MORGAN, T. R, HOEFS, J. C, STERLING, R. K, WAGNER, D. A, KULIG, C. C, CURTO, T. M, WRIGHT, E. C

“…The spectrum of functional impairment in patients with compensated chronic hepatitis C is incompletely defined. To define hepatic impairment by quantitative…”
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Portal‐systemic shunting in patients with fibrosis or cirrhosis due to chronic hepatitis C: the minimal model for measuring cholate clearances and shunt by EVERSON, G. T., MARTUCCI, M. A., SHIFFMAN, M. L., STERLING, R. K., MORGAN, T. R., HOEFS, J. C.

“…Summary Background  Measurement of portal inflow and portal‐systemic shunt using cholate clearances could be useful in monitoring patients with liver disease…”
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Peginterferon alfa‐2a/ribavirin in hepatitis C virus patients nontolerant or nonresponsive to peginterferon alfa‐2b/ribavirin by RUSTGI, V. K., ESPOSITO, S., HAMZEH, F. M., SHIFFMAN, M. L.

“…Summary Background  Peginterferon alfa‐2a/ribavirin treatment resulted in fewer incidences of depression and flu‐like symptoms than that of standard…”
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Primary sclerosing cholangitis: evaluation with MR cholangiography-a case-control study by Fulcher, A S, Turner, M A, Franklin, K J, Shiffman, M L, Sterling, R K, Luketic, V A, Sanyal, A J

“…To determine the accuracy of magnetic resonance (MR) cholangiography for detection of primary sclerosing cholangitis (PSC) and localization of PSC in the…”
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Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C by Shiffman, M L, Hofmann, C M, Thompson, E B, Ferreira‐Gonzalez, A, Contos, M J, Koshy, A, Luketic, V A, Sanyal, A J, Mills, A S, Garrett, C T

“…The present study was conducted to evaluate the relationship between biochemical, virological, and histological response during the course of interferon…”
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Complications of transjugular intrahepatic portosystemic shunt: a comprehensive review by Freedman, A M, Sanyal, A J, Tisnado, J, Cole, P E, Shiffman, M L, Luketic, V A, Purdum, P P, Darcy, M D, Posner, M P

“…It is generally accepted that the transjugular intrahepatic portosystemic shunt (TIPS) procedure has lower morbidity and mortality rates than those of surgical…”
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