Search Results - "SHEU, Joen R"

A Potent Antioxidant, Lycopene, Affords Neuroprotection Against Microglia Activation and Focal Cerebral Ischemia in Rats by Hsiao, George, Fong, Tsorng H, Tzu, Nien H, Lin, Kuan H, Chou, Duen S, Sheu, Joen R

“…We investigated the effects of a potent antioxidant, lycopene, on the free radical-scavenging activity as evaluated by the DPPH test and lipid peroxidation in…”
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Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: Regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade by Lu, Wan J., Lin, Kuan H., Hsu, Ming J., Chou, Duen S., Hsiao, George, Sheu, Joen R.

“…Andrographolide, a novel nuclear factor-κB (NF-κB) inhibitor, is isolated from leaves of Andrographis paniculata. Platelet activation is relevant to a variety…”
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Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP by Shen, Ming Y., Hsiao, George, Liu, Chang L., Fong, Tsorng H., Lin, Kuang H., Chou, Duen S., Sheu, Joen R.

“…Summary Resveratrol has been reported to have antiplatelet activity; however, the detailed mechanisms have not yet been resolved. This study aimed to…”
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Mechanisms of resveratrol-induced platelet apoptosis by Lin, Kuan H., Hsiao, George, Shih, Chwen M., Chou, Duen S., Sheu, Joen R.

“…Aims Apoptotic events have recently been found to occur in platelets, which are anuclear. Resveratrol is present in red wine and has various biological…”
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Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo by Lin, Kuan H., Kuo, Jinn R., Lu, Wan J., Chung, Chi L., Chou, Duen S., Huang, Shih Y., Lee, Hsiu C., Sheu, Joen R.

“…Hinokitiol is a tropolone-related bioactive compound that has been used in hair tonics, cosmetics, and food as an antimicrobial agent. Recently, hinokitiol has…”
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Mechanisms involved in the antiplatelet activity of Midazolam in human platelets by SHEU, Joen R, HSIAO, George, LUK, Hsiung N, CHEN, Yi W, CHEN, Ta L, LEE, Lin W, LIN, Chien H, CHOU, Duen S

“…Midazolam is widely used as a sedative and anesthetic induction agent. The aim of this study was to systematically examine the inhibitory mechanisms of…”
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Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase by Chang, Chao C., Lu, Wan J., Chiang, Cheng W., Jayakumar, Thanasekaran, Ong, Eng T., Hsiao, George, Fong, Tsorng H., Chou, Duen S., Sheu, Joen R.

“…Sesamol is a potent phenolic antioxidant which possesses antimutagenic, antihepatotoxic and antiaging properties. Platelet activation is relevant to a variety…”
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Protective Mechanisms of Inosine in Platelet Activation and Cerebral Ischemic Damage by Hsiao, George, Lin, Kuang H, Chang, Yi, Chen, Ta L, Tzu, Nien H, Chou, Duen S, Sheu, Joen R

“…OBJECTIVE—Inosine is a naturally occurring nucleoside degraded from adenosine. Recent studies have demonstrated that inosine has potent immunomodulatory and…”
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Amyloid beta peptide-activated signal pathways in human platelets by Shen, Ming Y., Hsiao, George, Fong, Tsorng H., Chen, Hui M., Chou, Duen S., Lin, Chien H., Sheu, Joen R., Hsu, Chung Y.

“…Amyloid beta peptide (amyloid-β), which accumulates in the cerebral microvessels in an age-dependent manner, plays a key role in the pathogenesis of cerebral…”
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Antithrombotic effects of tetramethylpyrazine in in vivo experiments by SHEU, Joen R, HSIAO, George, LEE, Yen M, YEN, Mao H

“…In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered…”
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Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets : In vitro and in vivo studies by HSIAO, George, LEE, Jie J, LIN, Kuang H, SHEN, Chia H, FONG, Tsorng H, CHOU, Duen S, SHEU, Joen R

“…Caffeic acid phenethyl ester (CAPE), which is derived from the propolis of honeybee hives, has been demonstrated to possess multiple pharmacological…”
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Antithrombotic effects of magnesium sulfate in in vivo experiments by SHEU, Joen R, HSIAO, George, SHEN, Ming Y, LEE, Yen M, YEN, Mao H

“…In this study, magnesium sulfate was effective in reducing the mortality of adenosine diphosphate-induced acute pulmonary thromboembolism in mice, when it was…”
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A novel role for tamoxifen in the inhibition of human platelets by Chang, Yi, Lee, Jie J, Chen, Wei F, Chou, Duen S, Huang, Shih Y, Sheu, Joen R

“…Tamoxifen, a selective estrogen receptor (ER) modulator (SERM), is widely used therapeutically for the treatment and prevention of breast cancer, but its use…”
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Expression of matrix metalloproteinase‐9 in human platelets: regulation of platelet activation in in vitro and in vivo studies by Sheu, Joen R, Fong, Tsorng H, Liu, Cheng M, Shen, Ming Y, Chen, Ta L, Chang, Yi, Lu, Meng S, Hsiao, George

“…The aim of this study was to identify the presence of matrix metalloproteinase‐9 (MMP‐9) in human platelets and systematically examine its inhibitory…”
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Andrographolide Enhances Nuclear Factor-κB Subunit p65 Ser536 Dephosphorylation through Activation of Protein Phosphatase 2A in Vascular Smooth Muscle Cells by Hsieh, Cheng Y., Hsu, Ming J., Hsiao, George, Wang, Yi H., Huang, Chi W., Chen, Shiuan W., Jayakumar, Thanasekaran, Chiu, Pei T., Chiu, Yi H., Sheu, Joen R.

“…Recent studies have demonstrated that transcription factor nuclear factor (NF)-κB inhibition may contribute to the protective anti-inflammatory actions of…”
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Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents by Lin, Kuan H., Chang, Huai C., Lu, Wan J., Jayakumar, Thanasekaran, Chou, Hsiu C., Fong, Tsorng H., Hsiao, George, Sheu, Joen R.

“…Apoptosis-like events are known to occur in anuclear platelets. Although the mechanisms responsible for these events are still not completely understood,…”
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Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments by Sheu, Joen R, Hsiao, George, Shen, Ming Y, Wang, Ying, Lin, Kuang H, Lin, Chien H, Chou, Duen S

“…Metallothionein (MT) is a low-molecular-weight, cysteine-rich protein that contains heavy metals such as cadmium and zinc. The biological function of MT in…”
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The antiplatelet activity of PMC, a potent α‐tocopherol analogue, is mediated through inhibition of cyclo‐oxygenase by Sheu, Joen R, Lee, Cheng R, Lin, Chang C, Kan, Ya C, Lin, Chien H, Hung, Wei C, Lee, Yen M, Yen, Mao H

“…PMC, a potent α‐tocopherol derivative, dose‐dependently (5–25 μM) inhibited the ATP‐release reaction and platelet aggregation in washed human platelets…”
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Triflavin, an Arg‐Gly‐Asp‐containing Antiplatelet Peptide Inhibits Cell‐substratum Adhesion and Melanoma Cell‐induced Lung Colonization by Sheu, Joen R., Lin, Chao H., Chung, Jih L., Teng, Che M., Huang, Tur F.

“…Triflavin, an Arg‐Gly‐Asp (RGD) containing peptide purified from Trimeresurus flavoviridis snake venom, inhibits human platelet aggregation by blocking…”
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Triflavin, an Arg‐Gly‐Asp‐containing Peptide, Inhibits Tumor Cell‐induced Platelet Aggregation by Sheu, Joen R., Lin, Chao H., Peng, Hui C., Teng, Che M., Huang, Tur F.

“…In this study, we examined the effect of triflavin, an Arg‐Gly‐Asp (RGD)‐containing snake venom peptide, on human cervical carcinoma (HeLa) cell‐ and B16‐F10…”
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