Search Results - "SHERR, C. J"

The pezcoller lecture : Cancer cell cycles revisited by SHERR, C. J

“…Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are present in most human cancers. Mitogen-dependent, cyclin D-dependent…”
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CDK inhibitors: positive and negative regulators of G1-phase progression by Sherr, C J, Roberts, J M

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis by Eischen, C M, Weber, J D, Roussel, M F, Sherr, C J, Cleveland, J L

“…Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Emu) develop B-cell lymphoma and exhibit a mean survival time…”
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Cancer Cell Cycles by Sherr, Charles J.

“…Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles…”
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D-type cyclin-dependent kinase activity in mammalian cells by MATSUSHIME, H, QUELLE, D. E, SHURTLEFF, S. A, SHIBUYA, M, SHERR, C. J, KATO, J.-Y

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Tumor spectrum in ARF-deficient mice by KAMIJO, T, BODNER, S, VAN DE KAMP, E, RANDLE, D. H, SHERR, C. J

“…The p19ARF product of the INK4a/ARF locus is induced in response to potentially oncogenic hyperproliferative signals and activates p53 by interfering with its…”
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Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1 by KATO, J.-Y, SHERR, C. J

“…Growth factor-induced signals govern the expression of three D-type cyclins, which, in turn, function as regulatory subunits of cyclin-dependent kinases (cdks)…”
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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6 by Hirai, Hiroshi, Roussel, Martine F., Kato, Jun-Ya, Ashmun, Richard A., Sherr, Charles J.

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4 by JUN-YA KATO, MATSUSHIME, H, HIEBERT, S. W, EWEN, M. E, SHERR, C. J

“…The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth-suppressive function is…”
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Principles of Tumor Suppression by Sherr, Charles J

“…Molecular genetic studies of familial cancer syndromes identified and defined the recessive nature of tumor suppressor genes and resolved the paradox of why…”
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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins by Ewen, M E, Sluss, H K, Sherr, C J, Matsushime, H, Kato, J, Livingston, D M

“…The retinoblastoma gene product (Rb) can interact efficiently with two of three D-type G1 cyclins (D2 and D3) in vitro. Binding depended upon the minimal…”
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A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase by Diehl, J. Alan, Sherr, Charles J.

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The RB and p53 pathways in cancer by Sherr, Charles J, McCormick, Frank

“…The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade…”
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Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d) by Zindy, F, den Besten, W, Chen, B, Rehg, J E, Latres, E, Barbacid, M, Pollard, J W, Sherr, C J, Cohen, P E, Roussel, M F

“…Male mice lacking both the Ink4c and Ink4d genes, which encode two inhibitors of D-type cyclin-dependent kinases (Cdks), are infertile, whereas female…”
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Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1 by Hirai, Hiroshi, Sherr, Charles J.

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The INK4a / ARF network in tumour suppression by Sherr, Charles J

“…The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding…”
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Mammalian G1 cyclins by Sherr, C J

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Colony-Stimulating Factor-1 Receptor by Sherr, Charles J.

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Tumor surveillance via the ARF-p53 pathway by Sherr, C J

“…The retinoblastoma (Rb) and p53 genes are not essential for completion of the cell division cycle, but disruption of their functions is central to the life…”
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Inhibitors of mammalian G1 cyclin-dependent kinases by Sherr, C J, Roberts, J M

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