Search Results - "SHERMAN, ARTHUR"

Closing in on the Mechanisms of Pulsatile Insulin Secretion by Bertram, Richard, Satin, Leslie S, Sherman, Arthur S

“…Insulin secretion from pancreatic islet β-cells occurs in a pulsatile fashion, with a typical period of ∼5 min. The basis of this pulsatility in mouse islets…”
Get full text

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes by Satin, Leslie S., Butler, Peter C., Ha, Joon, Sherman, Arthur S.

“…Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass cannot compensate for rising insulin resistance. Numerous studies have…”
Get full text

A Mathematical Model of the Pathogenesis, Prevention, and Reversal of Type 2 Diabetes by Ha, Joon, Satin, Leslie S, Sherman, Arthur S

“…Type 2 diabetes (T2D) is generally thought to result from the combination of 2 metabolic defects, insulin resistance, which increases the level of insulin…”
Get full text

Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling by Muniyappa, Ranganath, Chen, Hui, Montagnani, Monica, Sherman, Arthur, Quon, Michael J

“…Previously, we have used mathematical modeling to gain mechanistic insights into insulin-stimulated glucose uptake. Phosphatidylinositol 3-kinase…”
Get more information

A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth with Obesity by Ha, Joon, Kim, Joon Young, Springer, Max, Chhabra, Aaryan, Chung, Stephanie T, Sumner, Anne E, Sherman, Arthur, Arslanian, Silva

“…The gold standard clamp measurements for insulin sensitivity (cSI), β-cell function (cBCF) and disposition index (cDI = cSI*cBCF), are not practical in…”
Get full text

Do oscillations in pancreatic islets require pacemaker cells? by Peercy, Bradford E, Sherman, Arthur S

“…The pancreatic islets of Langerhans are biomedically important because they are home to the beta cells that secrete insulin and are hence important for…”
Get full text

One-hour glucose is an earlier marker of dysglycemia than two-hour glucose by Ha, Joon, Chung, Stephanie T., Bogardus, Clifton, Jagannathan, Ram, Bergman, Michael, Sherman, Arthur S.

“…The timing of increase in 1-hour PG and its utility as an earlier predictor of both prediabetes (PreDM) and type 2 diabetes (T2D) compared to 2-hour PG…”
Get full text

KATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production by Corradi, Jeremías, Thompson, Benjamin, Fletcher, Patrick A., Bertram, Richard, Sherman, Arthur S., Satin, Leslie S.

“…Pancreatic beta cells secrete insulin in response to plasma glucose. The ATP‐sensitive potassium channel (KATP) links glucose metabolism to islet electrical…”
Get full text

K ATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production by Corradi, Jeremías, Thompson, Benjamin, Fletcher, Patrick A, Bertram, Richard, Sherman, Arthur S, Satin, Leslie S

“…Pancreatic beta cells secrete insulin in response to plasma glucose. The ATP-sensitive potassium channel (K ) links glucose metabolism to islet electrical…”
Get full text

Oscillations in K(ATP) conductance drive slow calcium oscillations in pancreatic β-cells by Marinelli, Isabella, Thompson, Benjamin M., Parekh, Vishal S., Fletcher, Patrick A., Gerardo-Giorda, Luca, Sherman, Arthur S., Satin, Leslie S., Bertram, Richard

“…ATP-sensitive K+ (K(ATP)) channels were first reported in the β-cells of pancreatic islets in 1984, and it was soon established that they are the primary means…”
Get full text

The astroglial and stem cell functions of adult rat folliculostellate cells by Fletcher, Patrick A., Smiljanic, Kosara, Prévide, Rafael M., Constantin, Stephanie, Sherman, Arthur S., Coon, Steven L., Stojilkovic, Stanko S.

“…The mammalian pituitary gland is a complex organ consisting of hormone‐producing cells, anterior lobe folliculostellate cells (FSCs), posterior lobe…”
Get full text

Deconstructing the integrated oscillator model for pancreatic β-cells by Bertram, Richard, Marinelli, Isabella, Fletcher, Patrick A., Satin, Leslie S., Sherman, Arthur S.

“…Electrical bursting oscillations in the β-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by…”
Get full text

Determining the 1-hour post-load glucose which identifies diabetes in Africans: Insight from the Africans in America study by Kabeza, Claudine B., Ntabadde, Kauthrah, DuBose, Christopher W., Ha, Joon, Sherman, Arthur S., Sumner, Anne E.

“…Diagnosing diabetes by shortening the OGTT to 1-h and substituting 1-h post-load glucose (PG) ≥ 209 mg/dL for 2-h PG≥200 mg/dL has been proposed. One-hour…”
Get full text

Ca 2+ release or Ca 2+ entry, that is the question: what governs Ca 2+ oscillations in pancreatic β cells? by Fletcher, Patrick A, Thompson, Ben, Liu, Chanté, Bertram, Richard, Satin, Leslie S, Sherman, Arthur S

“…The standard model for Ca oscillations in insulin-secreting pancreatic β cells centers on Ca entry through voltage-activated Ca channels. These work in…”
Get more information

The Size of Large Adipose Cells Is a Predictor of Insulin Resistance in First‐Degree Relatives of Type 2 Diabetic Patients by Yang, Jian, Eliasson, Bjorn, Smith, Ulf, Cushman, Samuel W., Sherman, Arthur S.

“…Early studies reported that the size of adipose cells correlates with insulin resistance. However, a recent study comparing moderately obese, sensitive and…”
Get full text

Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells by Marinelli, Isabella, Fletcher, Patrick A, Sherman, Arthur S, Satin, Leslie S, Bertram, Richard

“…Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin,…”
Get full text

Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary by Sivcev, Sonja, Constantin, Stephanie, Smiljanic, Kosara, Sokanovic, Srdjan J., Fletcher, Patrick A., Sherman, Arthur S., Zemkova, Hana, Stojilkovic, Stanko S.

“…•The pituitary gland expresses the somatostatin receptor genes Sstr1, Sstr2, Sstr3, and Sstr5.•Gonadotrophs and lactotrophs express Sstr3; thyrotrophs Sstr1…”
Get full text

Modeling of Glucose-Induced cAMP Oscillations in Pancreatic β Cells: cAMP Rocks when Metabolism Rolls by Peercy, Bradford E., Sherman, Arthur S., Bertram, Richard

“…Recent advances in imaging technology have revealed oscillations of cyclic adenosine monophosphate (cAMP) in insulin-secreting cells. These oscillations may be…”
Get full text

When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action by Ha, Joon, Muniyappa, Ranganath, Sherman, Arthur S, Quon, Michael J

“…We address a problem with the Bergman-Cobelli Minimal Model, which has been used for 40 years to estimate during an intravenous glucose tolerance test (IVGTT)…”
Get full text

Hemoglobin Glycation Index Is Associated With Cardiovascular Diseases in People With Impaired Glucose Metabolism by Ahn, Chang Ho, Min, Se Hee, Lee, Dong-Hwa, Oh, Tae Jung, Kim, Kyoung Min, Moon, Jae Hoon, Choi, Sung Hee, Park, Kyong Soo, Jang, Hak Chul, Ha, Joon, Sherman, Arthur S, Lim, Soo

“…Abstract Context There is a substantial interindividual variation in the association between glycated hemoglobin (HbA1c) and plasma glucose concentrations. Its…”
Get full text