Search Results - "SHEPPARD, I"

Temporal presentations of heparin‐induced thrombocytopenia following cardiac surgery: A single‐center, retrospective cohort study by Warkentin, Theodore E., Sheppard, Jo‐Ann I., Whitlock, Richard P.

“…Background Heparin‐induced thrombocytopenia (HIT) is an important adverse drug reaction that can occur postcardiac surgery. Preoperative exposure to…”
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Serotonin‐release assay‐negative heparin‐induced thrombocytopenia by Warkentin, Theodore E., Nazy, Ishac, Sheppard, Jo‐Ann I., Smith, James W., Kelton, John G., Arnold, Donald M.

“…Heparin‐induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet‐activating anti‐platelet factor 4 (PF4)/heparin antibodies…”
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Combination of two complementary automated rapid assays for diagnosis of heparin‐induced thrombocytopenia (HIT) by Warkentin, Theodore E., Sheppard, Jo‐Ann I., Smith, James W., Li, Na, Moore, Jane C., Arnold, Donald M., Nazy, Ishac

“…Background HIT diagnosis typically uses complementary diagnostic assays (eg, a PF4‐dependent enzyme‐immunoassay [EIA] and a platelet activation assay such as…”
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Venous Thromboembolism and Mild Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination by Gabarin, Nadia, Patterson, Sarah, Pai, Menaka, Afzaal, Tamoor, Nazy, Ishac, Sheppard, Jo-Ann I, Arnold, Donald M, Warkentin, Theodore E

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High‐dose intravenous immunoglobulin to treat spontaneous heparin‐induced thrombocytopenia syndrome by Mohanty, Elan, Nazir, Salik, Sheppard, Jo‐Ann I., Forman, Daniel A., Warkentin, Theodore E.

“…Essentials Spontaneous HIT syndrome clinically/serologically resembles HIT but without proximate heparin. Rarely, spontaneous HIT syndrome complicates total…”
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Autoimmune heparin‐induced thrombocytopenia and venous limb gangrene after aortic dissection repair: in vitro and in vivo effects of intravenous immunoglobulin by Arcinas, Liane A., Manji, Rizwan A., Hrymak, Carmen, Dao, Vi, Sheppard, Jo‐Ann I., Warkentin, Theodore E.

“…BACKGROUND Heparin‐induced thrombocytopenia (HIT) is a prothrombotic disorder characterized by heparin‐dependent antibodies that activate platelets (PLTs) via…”
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Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL® HIT-ab(PF4-H) ] for the diagnosis of immune heparin-induced thrombocytopenia by Warkentin, Theodore E, Sheppard, Jo-Ann I, Linkins, Lori-Ann, Arnold, Donald M, Nazy, Ishac

“…Abstract Background Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating anti-PF4/heparin antibodies. Given…”
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Serotonin‐release assay‐positive but platelet factor 4‐dependent enzyme‐immunoassay negative: HIT or not HIT? by Warkentin, Theodore E., Smythe, Maureen A., Ali, Mona A., Aslam, Naveed, Sheppard, Jo‐Ann I., Smith, James W., Moore, Jane C., Arnold, Donald M., Nazy, Ishac

“…IgG‐specific and polyspecific PF4‐dependent enzyme‐immunoassays (EIAs) have exceptionally high sensitivity (≥99%) for diagnosis of heparin‐induced…”
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Plasma exchange to remove HIT antibodies: dissociation between enzyme-immunoassay and platelet activation test reactivities by Warkentin, Theodore E., Sheppard, Jo-Ann I., Chu, F. Victor, Kapoor, Anil, Crowther, Mark A., Gangji, Azim

“…Repeated therapeutic plasma exchange (TPE) has been advocated to remove heparin-induced thrombocytopenia (HIT) IgG antibodies before cardiac/vascular surgery…”
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Silylation-Based Kinetic Resolution of Monofunctional Secondary Alcohols by Sheppard, Cody I, Taylor, Jessica L, Wiskur, Sheryl L

“…The nucleophilic small molecule catalyst (−)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective…”
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Studies of the immune response in heparin-induced thrombocytopenia by Warkentin, Theodore E., Sheppard, Jo-Ann I., Moore, Jane C., Cook, Richard J., Kelton, John G.

“…Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating antibodies that recognize PF4/heparin complexes. Uncertainties remain regarding HIT…”
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Fondaparinux cross-reactivity in heparin-induced thrombocytopenia successfully treated with high-dose intravenous immunoglobulin and rivaroxaban by Manji, Farheen, Warkentin, Theodore E, Sheppard, Jo-Ann I, Lee, Adrienne

“…HIT, a prothrombotic disorder caused by heparin-dependent antibodies, is often treated with fondaparinux, usually with good outcomes. A 70-year-old female…”
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Gender imbalance and risk factor interactions in heparin-induced thrombocytopenia by Warkentin, Theodore E., Sheppard, Jo-Ann I., Sigouin, Christopher S., Kohlmann, Thomas, Eichler, Petra, Greinacher, Andreas

“…Heparin-induced thrombocytopenia (HIT) is caused by antibodies against a “self” protein—platelet factor 4—bound to heparin. We observed an overrepresentation…”
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The temporal profile of the anti-PF4/heparin immune response by Greinacher, Andreas, Kohlmann, Thomas, Strobel, Ulrike, Sheppard, Jo-Ann I., Warkentin, Theodore E.

“…The immune response in heparin-induced thrombocytopenia (HIT) is puzzling: heparin-naive patients can develop IgG antibodies and clinical HIT as early as day…”
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Timeline of heparin‐induced thrombocytopenia seroconversion in serial plasma samples tested using an automated latex immunoturbidimetric assay by Warkentin, Theodore E., Sheppard, Jo‐Ann I., Smith, James W., Arnold, Donald M., Nazy, Ishac

“…Introduction HIT is caused by platelet‐activating IgG that recognize multimolecular PF4/heparin complexes. HIT antibodies are generally detectable by…”
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Risk Indicator for Agricultural Inputs of Trace Elements to Canadian Soils by Sheppard, S. C., Grant, C. A., Sheppard, M. I., de Jong, R., Long, J.

“…Trace elements (TEs) are universally present in environmental media, including soil, but agriculture uses some materials that have increased TE concentrations…”
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Understanding Internal Chirality Induction of Triarylsilyl Ethers Formed from Enantiopure Alcohols by Wang, Li, Zhang, Tian, Redden, Brandon K, Sheppard, Cody I, Clark, Robert W, Smith, Mark D, Wiskur, Sheryl L

“…Chirality transmission from point chirality to helical chirality was explored using triarylsilyl ethers. Circular dichroism (CD) spectroscopy was employed to…”
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Heparin-Induced Thrombocytopenia in Medical Surgical Critical Illness by Warkentin, Theodore E., MD, Sheppard, Jo-Ann I., BSc, Heels-Ansdell, Diane, MSc, Marshall, John C., MD, McIntyre, Lauralyn, MD, Rocha, Marcelo G., MD, Mehta, Sangeeta, MD, Davies, Andrew R., MD, Bersten, Andrew D., MD, Crozier, Tim M., MD, Ernest, David, MD, Vlahakis, Nicholas E., MD, FCCP, Hall, Richard I., MD, FCCP, Wood, Gordon G., MD, Poirier, Germain, MD, Crowther, Mark A., MD, Cook, Deborah J., MD

“…Background In a recent multicenter randomized trial comparing unfractionated heparin (UFH) with low-molecular-weight heparin (dalteparin) for…”
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High‐dose IVIG plus cangrelor platelet “anesthesia” during urgent heparin‐CPB in a patient with recent SRA‐negative HIT‐thrombosis with persisting platelet‐activating antibodies by Koster, Andreas, Nazy, Ishac, Birschmann, Ingvild E., Smith, James W., Sheppard, Jo‐Ann I., Warkentin, Theodore E.

“…In a high‐risk patient with subacute heparin‐induced thrombocytopenia (HIT) type A (platelet count recovery following acute HIT but with persisting…”
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Adenovirus-Associated Thrombocytopenia, Thrombosis, and VITT-like Antibodies by Warkentin, Theodore E., Baskin-Miller, Jacquelyn, Raybould, Alison L., Sheppard, Jo-Ann I., Daka, Mercy, Nazy, Ishac, Moll, Stephan

“…VITT is caused by antibodies to PF4 that recognize the heparin-binding site. Thrombocytopenia and thrombosis associated with VITT-like antibody specificity…”
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