Search Results - "SHENOY, Shilpa R"

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays by Sztuba-Solinska, Joanna, Shenoy, Shilpa R, Gareiss, Peter, Krumpe, Lauren R. H, Le Grice, Stuart F. J, O’Keefe, Barry R, Schneekloth, John S

“…Identifying small molecules that selectively bind to structured RNA motifs remains an important challenge in developing potent and specific therapeutics. Most…”
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Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae by O'KEEFE, Barry R, GIOMARELLI, Barbara, MCCRAY, Paul B, BARNARD, Dale L, SHENOY, Shilpa R, CHAN, Paul K. S, MCMAHON, James B, PALMER, Kenneth E, BARNETT, Brian W, MEYERHOLZ, David K, WOHLFORD-LENANE, Christine L

“…Erratum ( vol. 84 , p. 5456 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity by Moulaei, Tinoush, Shenoy, Shilpa R., Giomarelli, Barbara, Thomas, Cheryl, McMahon, James B., Dauter, Zbigniew, O'Keefe, Barry R., Wlodawer, Alexander

“…Mutations were introduced to the domain-swapped homodimer of the antiviral lectin griffithsin (GRFT). Whereas several single and double mutants remained…”
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Structures of the Complexes of a Potent Anti-HIV Protein Cyanovirin-N and High Mannose Oligosaccharides by Botos, Istvan, O’Keefe, Barry R., Shenoy, Shilpa R., Cartner, Laura K., Ratner, Daniel M., Seeberger, Peter H., Boyd, Michael R., Wlodawer, Alexander

“…The development of anti-human immunodeficiency virus (HIV) microbicides for either topical or ex vivo use is of considerable interest, mainly due to the…”
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Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin by Ziółkowska, Natasza E., Shenoy, Shilpa R., O'Keefe, Barry R., McMahon, James B., Palmer, Kenneth E., Dwek, Raymond A., Wormald, Mark R., Wlodawer, Alexander

“…The mode of binding of oligosaccharides to griffithsin, an antiviral lectin from the red alga Griffithsia sp., was investigated by a combination of X‐ray…”
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The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation by Matarlo, Joe S, Krumpe, Lauren R H, Heinz, William F, Oh, Daniel, Shenoy, Shilpa R, Thomas, Cheryl L, Goncharova, Ekaterina I, Lockett, Stephen J, O'Keefe, Barry R

“…Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Using a…”
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Preclinical Manufacture of Anti-HER2 Liposome-Inserting, scFv-PEG-Lipid Conjugate. 2. Conjugate Micelle Identity, Purity, Stability, and Potency Analysis by Nellis, David F., Giardina, Steven L., Janini, George M., Shenoy, Shilpa R., Marks, James D., Tsai, Richard, Drummond, Daryl C., Hong, Keelung, Park, John W., Ouellette, Thomas F., Perkins, Shelley C., Kirpotin, Dmitri B.

“…Analytical methods optimized for micellar F5cys‐MP‐PEG(2000)‐DPSE protein‐lipopolymer conjugate are presented. The apparent micelle molecular weight,…”
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Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2 by Muñoz-Basagoiti, Jordana, Monteiro, Fábio Luís Lima, Krumpe, Lauren R H, Armario-Najera, Victoria, Shenoy, Shilpa R, Perez-Zsolt, Daniel, Westgarth, Harrison James, Villorbina, Gemma, Bomfim, Larissa Maciel, Raïch-Regué, Dàlia, Nogueras, Lara, Henrich, Curtis J, Gallemí, Marçal, Moreira, Filipe Romero Rebello, Torres, Pascual, Wilson, Jennifer, D'arc, Mirela, Marfil, Silvia, Herlinger, Alice Laschuk, Pradenas, Edwards, Higa, Luiza Mendonça, Portero-Otin, Manuel, Trinité, Benjamin, Twyman, Richard M, Capell, Teresa, Tanuri, Amilcar, Blanco, Julià, Izquierdo-Useros, Nuria, Rech, Elibio L, Christou, Paul, O'Keefe, Barry R

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive stranded RNA virus which has caused the recent deadly pandemic called…”
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Physicochemical characterization of the recombinant lectin scytovirin and microbicidal activity of the SD1 domain produced in rice against HIV-1 by Armario-Najera, Victoria, Blanco-Perera, Amaya, Shenoy, Shilpa R., Sun, Yi, Marfil, Silvia, Muñoz-Basagoiti, Jordana, Perez-Zsolt, Daniel, Blanco, Julià, Izquierdo-Useros, Nuria, Capell, Teresa, O’Keefe, Barry R., Christou, Paul

“…Key message Rice-produced SD1 retains its physicochemical properties and provides efficient pre-exposure HIV-1 prophylaxis against infection in vitro…”
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KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma by Kim, Yong Yean, Gryder, Berkley E., Sinniah, Ranuka, Peach, Megan L., Shern, Jack F., Abdelmaksoud, Abdalla, Pomella, Silvia, Woldemichael, Girma M., Stanton, Benjamin Z., Milewski, David, Barchi, Joseph J., Schneekloth, John S., Chari, Raj, Kowalczyk, Joshua T., Shenoy, Shilpa R., Evans, Jason R., Song, Young K., Wang, Chaoyu, Wen, Xinyu, Chou, Hsien-Chao, Gangalapudi, Vineela, Esposito, Dominic, Jones, Jane, Procter, Lauren, O’Neill, Maura, Jenkins, Lisa M., Tarasova, Nadya I., Wei, Jun S., McMahon, James B., O’Keefe, Barry R., Hawley, Robert G., Khan, Javed

“…Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting…”
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Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1 by Nicklaus, Marc C, Appella, Ettore, Liu, Fa, Lee, Sunhee, Lee, Kyung S, Park, Jung-Eun, Burke Jr, Terrence R, McMahon, James B, Otaka, Akira, Shenoy, Shilpa R, Liao, Chenzhong, Yaffe, Michael B, Soung, Nak-Kyun, Wlodawer, Alexander, Yun, Sang-Moon, Yoon, Do-Young, Lim, Dan, Bang, Jeong K, Moulaei, Tinoush, Kang, Young H, Lim, Yoongho, Lee, Dong-Hee

“…The Plk1 kinase is a major regulator of mitosis that is often overexpressed in human cancers. Studies on phosphopeptide inhibitors specific to the polo-box…”
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Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus by Moulaei, Tinoush, Alexandre, Kabamba B, Shenoy, Shilpa R, Meyerson, Joel R, Krumpe, Lauren Rh, Constantine, Brian, Wilson, Jennifer, Buckheit, Jr, Robert W, McMahon, James B, Subramaniam, Sriram, Wlodawer, Alexander, O'Keefe, Barry R

“…The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is…”
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Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor by Wilson, Brice A P, Alam, Muhammad S, Guszczynski, Tad, Jakob, Michal, Shenoy, Shilpa R, Mitchell, Carter A, Goncharova, Ekaterina I, Evans, Jason R, Wipf, Peter, Liu, Gang, Ashwell, Jonathan D, O'Keefe, Barry R

“…Mitogen-activated protein kinase (MAPK) p38 is part of a broad and ubiquitously expressed family of MAPKs whose activity is responsible for mediating an…”
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Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N‐acetylglucosamine by Ziółkowska, Natasza E., Shenoy, Shilpa R., O'Keefe, Barry R., Wlodawer, Alexander

“…Crystal structures of complexes of an antiviral lectin griffithsin (GRFT) with glucose and N‐acetylglucosamine were solved and refined at high resolution. In…”
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Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides by Fisher, Robert J., Fivash, Matthew J., Stephen, Andrew G., Hagan, Nathan A., Shenoy, Shilpa R., Medaglia, Maxine V., Smith, Lindsey R., Worthy, Karen M., Simpson, John T., Shoemaker, Robert, McNitt, Karen L., Johnson, Donald G., Hixson, Catherine V., Gorelick, Robert J., Fabris, Daniele, Henderson, Louis E., Rein, Alan

“…The HIV-1 nucleocapsid (NC) protein is a small, basic protein containing two retroviral zinc fingers. It is a highly active nucleic acid chaperone; because of…”
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Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner by Bolmstedt, A J, O'Keefe, B R, Shenoy, S R, McMahon, J B, Boyd, M R

“…Herein we report that the novel HIV-inactivating protein cyanovirin-N (CV-N) targets specific, N-linked high-mannose oligosaccharides found on the viral…”
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Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1 by Yun, Sang-Moon, Moulaei, Tinoush, Lim, Dan, Bang, Jeong K, Park, Jung-Eun, Shenoy, Shilpa R, Liu, Fa, Kang, Young H, Liao, Chenzhong, Soung, Nak-Kyun, Lee, Sunhee, Yoon, Do-Young, Lim, Yoongho, Lee, Dong-Hee, Otaka, Akira, Appella, Ettore, McMahon, James B, Nicklaus, Marc C, Burke, Terrence R, Yaffe, Michael B, Wlodawer, Alexander, Lee, Kyung S

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Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins by Shenoy, S R, O'Keefe, B R, Bolmstedt, A J, Cartner, L K, Boyd, M R

“…The virucidal protein cyanovirin-N (CV-N) mediates its highly potent anti-human immunodeficiency virus activity, at least in part, through interactions with…”
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Analysis of the interaction between the HIV-inactivating protein cyanovirin-N and soluble forms of the envelope glycoproteins gp120 and gp41 by O'Keefe, B R, Shenoy, S R, Xie, D, Zhang, W, Muschik, J M, Currens, M J, Chaiken, I, Boyd, M R

“…The novel virucidal protein cyanovirin-N (CV-N) binds with equally high affinity to soluble forms of either H9 cell-produced or recombinant glycosylated HIV-1…”
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Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides by Fisher, Robert J., Fivash, Matthew J., Stephen, Andrew G., Hagan, Nathan A., Shenoy, Shilpa R., Medaglia, Maxine V., Smith, Lindsey R., Worthy, Karen M., Simpson, John T., Shoemaker, Robert, McNitt, Karen L., Johnson, Donald G., Hixson, Catherine V., Gorelick, Robert J., Fabris, Daniele, Henderson, Louis E., Rein, Alan

“…The HIV-1 nucleocapsid (NC) protein is a small, basic protein containing two retroviral zinc fingers. It is a highly active nucleic acid chaperone; because of…”
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