Search Results - "SHENLAN MAO"

Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site by Kumar, Amit, Mao, Shenlan, Dimasi, Nazzareno, Gao, Changshou

“…First-generation cysteine-based site-specific antibody-drug conjugates (ADCs) are limited to one drug per cysteine. However, certain applications require a…”
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Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine by Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.

“…Synthetic pyrrolobenzodiazepine (PBD) dimers, where two PBD monomers are linked through their aromatic A-ring phenolic C8-positions via a flexible propyldioxy…”
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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4 by Harper, Jay, Lloyd, Christopher, Dimasi, Nazzareno, Toader, Dorin, Marwood, Rose, Lewis, Leeanne, Bannister, David, Jovanovic, Jelena, Fleming, Ryan, D'Hooge, Francois, Mao, Shenlan, Marrero, Allison M, Korade, 3rd, Martin, Strout, Patrick, Xu, Linda, Chen, Cui, Wetzel, Leslie, Breen, Shannon, van Vlerken-Ysla, Lilian, Jalla, Sanjoo, Rebelatto, Marlon, Zhong, Haihong, Hurt, Elaine M, Hinrichs, Mary Jane, Huang, Keven, Howard, Philip W, Tice, David A, Hollingsworth, Robert E, Herbst, Ronald, Kamal, Adeela

“…Antibody-drug conjugates (ADC) are used to selectively deliver cytotoxic agents to tumors and have the potential for increased clinical benefit to cancer…”
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Hydrolytically Stable Site-Specific Conjugation at the N‑Terminus of an Engineered Antibody by Thompson, Pamela, Bezabeh, Binyam, Fleming, Ryan, Pruitt, Monica, Mao, Shenlan, Strout, Patrick, Chen, Cui, Cho, Song, Zhong, Haihong, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

“…Antibody–drug conjugates (ADCs) have emerged as an important class of therapeutics for cancer treatment that combine the target specificity of antibodies with…”
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Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates by Thompson, Pamela, Ezeadi, Ebele, Hutchinson, Ian, Fleming, Ryan, Bezabeh, Binyam, Lin, Jia, Mao, Shenlan, Chen, Cui, Masterson, Luke, Zhong, Haihong, Toader, Dorin, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

“…Antibody–drug conjugates (ADCs) have become a powerful platform to deliver cytotoxic agents selectively to cancer cells. ADCs have traditionally been prepared…”
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EphA2 Immunoconjugate as Molecularly Targeted Chemotherapy for Ovarian Carcinoma by Lee, Jeong-Won, Han, Hee Dong, Shahzad, Mian M. K., Kim, Seung Wook, Mangala, Lingegowda S., Nick, Alpa M., Lu, Chunhua, Langley, Robert R., Schmandt, Rosemarie, Kim, Hye-Sun, Mao, Shenlan, Gooya, John, Fazenbaker, Christine, Jackson, Dowdy, Tice, David A., Landen, Charles N., Coleman, Robert L., Sood, Anil K.

“…Background EphA2 is overexpressed in many types of human cancer but is absent or expressed at low levels in normal epithelial tissues. We investigated whether…”
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EphA2 Targeted Chemotherapy Using an Antibody Drug Conjugate in Endometrial Carcinoma by LEE, Jeong-Won, STONE, Rebecca L, JENNINGS, Nicholas B, SHENLAN MAO, GOOYA, John, JACKSON, Dowdy, COLEMAN, Robert L, SOOD, Anil K, SUN JOO LEE, EUN JI NAM, ROH, Ju-Won, NICK, Alpa M, HAN, Hee-Dong, SHAHZAD, Mian M. K, KIM, Hye-Sun, MANGALA, Lingegowda S

“…EphA2 overexpression is frequently observed in endometrial cancers and is predictive of poor clinical outcome. Here, we use an antibody drug conjugate…”
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Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation by Christie, R., Tiberghien, Arnaud, Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip, Gao, Changshou

“…Thiosuccinimide-linked antibody-drug conjugates (ADCs) are susceptible to drug loss over time due to a retro-Michael reaction, which can be prevented by…”
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A Method for the Generation of Combinatorial Antibody Libraries Using pIX Phage Display by Gao, Changshou, Mao, Shenlan, Kaufmann, Gunnar, Wirsching, Peter, Lerner, Richard A., Janda, Kim D.

“…For more than a decade, phage displayed combinatorial antibody libraries have been used to generate and select a wide variety of antibodies. We previously…”
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Making Artificial Antibodies: A Format for Phage Display of Combinatorial Heterodimeric Arrays by Gao, Changshou, Mao, Shenlan, Lo, Chih-Hung L., Wirsching, Peter, Lerner, Richard A., Janda, Kim D.

“…The gene VII protein (pVII) and gene IX protien (pIX) are associated closely on the surface of filamentous bacteriophage that is opposite of the end harboring…”
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Phage-Display Selection of a Human Single-Chain Fv Antibody Highly Specific for Melanoma and Breast Cancer Cells Using a Chemoenzymatically Synthesized GM3−Carbohydrate Antigen by Lee, Kyung Joo, Mao, Shenlan, Sun, Chengzao, Gao, Changshou, Blixt, Ola, Arrues, Sandra, Hom, Louis G, Kaufmann, Gunnar F, Hoffman, Timothy Z, Coyle, Avery R, Paulson, James, Felding-Habermann, Brunhilde, Janda, Kim D

“…Overexpression of the cell-surface glycosphingolipid GM3 is associated with a number of different cancers, including those of the skin, colon, breast, and…”
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Combinatorial Antibody Libraries from Cancer Patients Yield Ligand-Mimetic Arg-Gly-Asp-Containing Immunoglobulins That Inhibit Breast Cancer Metastasis by Felding-Habermann, Brunhilde, Lerner, Richard A., Lillo, Antonietta, Zhuang, Shufei, Weber, Martin R., Arrues, Sandra, Gao, Changshou, Mao, Shenlan, Saven, Alan, Janda, Kim D.

“…Combinatorial antibody libraries have the potential to display the entire immunological record of an individual, allowing one to detect and recover any…”
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De novo identification of tumor-specific internalizing human antibody–receptor pairs by phage-display methods by Gao, Changshou, Mao, Shenlan, Ronca, Francesca, Zhuang, Sufei, Quaranta, Vito, Wirsching, Peter, Janda, Kim D

“…Three tumor-specific, internalizing human single-chain Fvs (scFvs) were obtained by direct selection against tumor cells from a large, nonimmune scFv-phage…”
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A cell-penetrating peptide from a novel pVII–pIX phage-displayed random peptide library by Gao, Changshou, Mao, Shenlan, Ditzel, Henrik J., Farnaes, Lauge, Wirsching, Peter, Lerner, Richard A., Janda, Kim D.

“…A novel random peptide library was constructed using a phage-display format on the coat proteins pVII and pIX of filamentous bacteriophage. Panning against…”
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Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides by Christie, R. James, Fleming, Ryan, Bezabeh, Binyam, Woods, Rob, Mao, Shenlan, Harper, Jay, Joseph, Augustine, Wang, Qianli, Xu, Ze-Qi, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

“…Maleimides are often used to covalently attach drugs to cysteine thiols for production of antibody–drug conjugates (ADCs). However, ADCs formed with…”
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Making Chemistry Selectable by Linking it to Infectivity by Gao, C, Lin, C H, Lo, C H, Mao, S, Wirsching, P, Lerner, R A, Janda, K D

“…The link between recognition and replication is fundamental to the operation of the immune system. In recent years, modeling this process in a format of…”
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Synthesis of Solid-Supported Mirror-Image Sugars: A Novel Method for Selecting Receptors for Cellular-Surface Carbohydrates by Kozlov, Igor A., Mao, Shenlan, Xu, Yue, Huang, Xuefei, Lee, Lac, Sears, Pamela S., Gao, Changshou, Coyle, Avery R., Janda, Kim D., Wong, Chi-Huey

“…We introduced a novel method, through mirror‐image phage display, for the identification of high‐affinity D‐peptides to target specific cell‐surface…”
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Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers by St. Amant, Andre H, Lemen, Daniel, Florinas, Stelios, Mao, Shenlan, Fazenbaker, Christine, Zhong, Haihong, Wu, Herren, Gao, Changshou, Christie, R. James, Read de Alaniz, Javier

“…The thiol–maleimide linkage is widely used for antibody–drug conjugate (ADC) production; however, conjugation of maleimide–drugs could be improved by…”
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A Diene‐Containing Noncanonical Amino Acid Enables Dual Functionality in Proteins: Rapid Diels–Alder Reaction with Maleimide or Proximity‐Based Dimerization by St. Amant, Andre H., Huang, Fengying, Lin, Jia, Rickert, Keith, Oganesyan, Vaheh, Lemen, Daniel, Mao, Shenlan, Harper, Jay, Marelli, Marcello, Wu, Herren, Gao, Changshou, Read de Alaniz, Javier, Christie, R. James

“…Here, we describe a diene‐containing noncanonical amino acid (ncAA) capable of undergoing fast and selective normal electron‐demand Diels–Alder (DA) reactions…”
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Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics by Thompson, Pamela, Fleming, Ryan, Bezabeh, Binyam, Huang, Fengying, Mao, Shenlan, Chen, Cui, Harper, Jay, Zhong, Haihong, Gao, Xizhe, Yu, Xiang-Qing, Hinrichs, Mary Jane, Reed, Molly, Kamal, Adeela, Strout, Patrick, Cho, Song, Woods, Rob, Hollingsworth, Robert E., Dixit, Rakesh, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

“…Antibody-drug conjugates (ADCs) are among the most promising empowered biologics for cancer treatment. ADCs are commonly prepared by chemical conjugation of…”
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