Search Results - "SHENG, Morgan"

Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond by Bingol, Baris, Sheng, Morgan

“…Mitochondrial quality control is central for maintaining a healthy population of mitochondria. Two Parkinson’s disease genes, mitochondrial kinase PINK1 and…”
Get full text

Microglia in Alzheimer's disease by Hansen, David V, Hanson, Jesse E, Sheng, Morgan

“…Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer's disease (AD). Human genetics…”
Get full text

The postsynaptic architecture of excitatory synapses: a more quantitative view by Sheng, Morgan, Hoogenraad, Casper C

“…Excitatory (glutamatergic) synapses in the mammalian brain are usually situated on dendritic spines, a postsynaptic microcompartment that also harbors…”
Get full text

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease by Bingol, Baris, Sheng, Morgan

“…The brain changes in response to experience and altered environment. This neural plasticity is largely mediated by morphological and functional modification of…”
Get full text

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies by Dejanovic, Borislav, Huntley, Melanie A., De Mazière, Ann, Meilandt, William J., Wu, Tiffany, Srinivasan, Karpagam, Jiang, Zhiyu, Gandham, Vineela, Friedman, Brad A., Ngu, Hai, Foreman, Oded, Carano, Richard A.D., Chih, Ben, Klumperman, Judith, Bakalarski, Corey, Hanson, Jesse E., Sheng, Morgan

“…Synapse loss and Tau pathology are hallmarks of Alzheimer’s disease (AD) and other tauopathies, but how Tau pathology causes synapse loss is unclear. We used…”
Get full text

TREM2, Microglia, and Neurodegenerative Diseases by Yeh, Felix L, Hansen, David V, Sheng, Morgan

“…Alzheimer’s disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. The neuropathological hallmarks of the disease are…”
Get full text

Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms by Ertürk, Ali, Wang, Yuanyuan, Sheng, Morgan

“…Synapse loss occurs normally during development and pathologically during neurodegenerative disease. Long-term depression, a proposed physiological correlate…”
Get full text

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia by Yeh, Felix L., Wang, Yuanyuan, Tom, Irene, Gonzalez, Lino C., Sheng, Morgan

“…Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are associated with Alzheimer’s disease (AD). Starting from an unbiased…”
Get full text

Caspase-3 in the central nervous system: beyond apoptosis by D’Amelio, Marcello, Sheng, Morgan, Cecconi, Francesco

“…Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its…”
Get full text

Microglia in Brain Development, Homeostasis, and Neurodegeneration by Bohlen, Christopher J, Friedman, Brad A, Dejanovic, Borislav, Sheng, Morgan

“…Advances in human genetics have implicated a growing number of genes in neurodegenerative diseases, providing insight into pathological processes. For…”
Get full text

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation by Chang, Michael C, Srinivasan, Karpagam, Friedman, Brad A, Suto, Eric, Modrusan, Zora, Lee, Wyne P, Kaminker, Joshua S, Hansen, David V, Sheng, Morgan

“…Loss-of-function mutations in cause frontotemporal dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)-positive inclusions and…”
Get full text

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci by Chang, Diana, Nalls, Mike A, Hallgrímsdóttir, Ingileif B, Hunkapiller, Julie, van der Brug, Marcel, Cai, Fang, Kerchner, Geoffrey A, Ayalon, Gai, Bingol, Baris, Sheng, Morgan, Hinds, David, Behrens, Timothy W, Singleton, Andrew B, Bhangale, Tushar R, Graham, Robert R

“…Robert Graham and colleagues carried out a GWAS meta-analysis for Parkinson's disease (PD) and report 17 new risk loci. Their analyses support a key role for…”
Get full text

PDZ domain proteins of synapses by Kim, Eunjoon, Sheng, Morgan

“…PDZ domains are protein-interaction domains that are often found in multi-domain scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into…”
Get full text

Molecular mechanisms of dendritic spine morphogenesis by Tada, Tomoko, Sheng, Morgan

“…Excitatory synapses are formed on dendritic spines, postsynaptic structures that change during development and in response to synaptic activity. Once mature,…”
Get full text

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology by Lee, Seung-Hye, Meilandt, William J., Xie, Luke, Gandham, Vineela D., Ngu, Hai, Barck, Kai H., Rezzonico, Mitchell G., Imperio, Jose, Lalehzadeh, Guita, Huntley, Melanie A., Stark, Kimberly L., Foreman, Oded, Carano, Richard A.D., Friedman, Brad A., Sheng, Morgan, Easton, Amy, Bohlen, Christopher J., Hansen, David V.

“…Loss-of-function TREM2 mutations strongly increase Alzheimer’s disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models…”
Get full text

USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-Dependent Protein Levels by Kerrisk Campbell, Meghan, Sheng, Morgan

“…Mutations or altered protein levels of SHANK3 are implicated in neurodevelopmental disorders such as Phelan-McDermid syndrome, autism spectrum disorders, and…”
Get full text

Molecular Organization of the Postsynaptic Specialization by Sheng, Morgan

“…A specific set of molecules including glutamate receptors is targeted to the postsynaptic specialization of excitatory synapses in the brain, gathering in a…”
Get full text

Postsynaptic Signaling and Plasticity Mechanisms by Sheng, Morgan, Kim, Myung Jong

“…In excitatory synapses of the brain, specific receptors in the postsynaptic membrane lie ready to respond to the release of the neurotransmitter glutamate from…”
Get full text

The growing role of mTOR in neuronal development and plasticity by Jaworski, Jacek, Sheng, Morgan

“…Neuronal development and synaptic plasticity are highly regulated processes in which protein kinases play a key role. Recently, increasing attention has been…”
Get full text

Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior by Wöhr, Markus, Roullet, Florence I, Hung, Albert Y, Sheng, Morgan, Crawley, Jacqueline N

“…Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in…”
Get full text