Search Results - "SHEN, Yu J"

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells by Shen, Yu J, Le Bert, Nina, Chitre, Anuja A, Koo, Christine Xing'Er, Nga, Xing H, Ho, Samantha S W, Khatoo, Muznah, Tan, Nikki Y, Ishii, Ken J, Gasser, Stephan

“…The DNA damage response (DDR) induces the expression of type I interferons (IFNs), but the underlying mechanisms are poorly understood. Here, we show the…”
Get full text

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression by Kawano, Yawara, Zavidij, Oksana, Park, Jihye, Moschetta, Michele, Kokubun, Katsutoshi, Mouhieddine, Tarek H, Manier, Salomon, Mishima, Yuji, Murakami, Naoka, Bustoros, Mark, Pistofidis, Romanos Sklavenitis, Reidy, Mairead, Shen, Yu J, Rahmat, Mahshid, Lukyanchykov, Pavlo, Karreci, Esilida Sula, Tsukamoto, Shokichi, Shi, Jiantao, Takagi, Satoshi, Huynh, Daisy, Sacco, Antonio, Tai, Yu-Tzu, Chesi, Marta, Bergsagel, P Leif, Roccaro, Aldo M, Azzi, Jamil, Ghobrial, Irene M

“…Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive…”
Get full text

RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma by LAM, Adeline R, LE BERT, Nina, RAULET, David H, GASSER, Stephan, HO, Samantha S. W, SHEN, Yu J, TANG, Melissa L. F, XIONG, Gordon M, CROXFORD, J. Ludovic, KOO, ChristineX, ISHII, Ken J, AKIRA, Shizuo

“…The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands…”
Get full text

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma by Manier, Salomon, Huynh, Daisy, Shen, Yu J, Zhou, Jia, Yusufzai, Timur, Salem, Karma Z, Ebright, Richard Y, Shi, Jiantao, Park, Jihye, Glavey, Siobhan V, Devine, William G, Liu, Chia-Jen, Leleu, Xavier, Quesnel, Bruno, Roche-Lestienne, Catherine, Snyder, John K, Brown, Lauren E, Gray, Nathanael, Bradner, James, Whitesell, Luke, Porco, Jr, John A, Ghobrial, Irene M

“…Multiple myeloma (MM) is a frequently incurable hematological cancer in which overactivity of MYC plays a central role, notably through up-regulation of…”
Get more information

Microbial fuel-cell-based toxicity sensor for fast monitoring of acidic toxicity by Shen, Yu J, Lefebvre, Olivier, Tan, Zi, Ng, How Y

“…Wastewater may contain various potential toxicants. A microbial fuel cell (MFC) is a device in which bacteria convert the chemical energy into electricity. If…”
Get full text

RNA Polymerase III Regulates Cytosolic RNA:DNA Hybrids and Intracellular MicroRNA Expression by Koo, Christine Xing'er, Kobiyama, Kouji, Shen, Yu J., LeBert, Nina, Ahmad, Shandar, Khatoo, Muznah, Aoshi, Taiki, Gasser, Stephan, Ishii, Ken J.

“…DNA hybrids form in the nuclei and mitochondria of cells as transcription-induced R-loops or G-quadruplexes, but exist only in the cytosol of virus-infected…”
Get full text

Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells by Shen, Yu J., Ho, Samantha S.W., Tan, Nikki Y., Koo, Christine Xing’Er, Khatoo, Muznah, Cheung, Florence S.G., Gasser, Stephan

“…•Genome-derived ssDNA, dsDNA and DNA:RNA hybrids are present in the cytosol of tumor cells.•Cytosolic DNA can potentially form non-B DNA structures.•Cytosolic…”
Get full text

STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression by Le Bert, Nina, Lam, Adeline R, Ho, Samantha SW, Shen, Yu J, Liu, Mo M, Gasser, Stephan

“…The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs). 1,2 We have recently reported that the DDR also induces the presence of…”
Get full text

Blocking IFNAR1 inhibits multiple myeloma–driven Treg expansion and immunosuppression by Kawano, Yawara, Zavidij, Oksana, Park, Jihye, Moschetta, Michele, Kokubun, Katsutoshi, Mouhieddine, Tarek H, Manier, Salomon, Mishima, Yuji, Murakami, Naoka, Bustoros, Mark, Pistofidis, Romanos Sklavenitis, Reidy, Mairead, Shen, Yu J, Rahmat, Mahshid, Lukyanchykov, Pavlo, Karreci, Esilida Sula, Tsukamoto, Shokichi, Shi, Jiantao, Takagi, Satoshi, Huynh, Daisy, Sacco, Antonio, Tai, Yu-Tzu, Chesi, Marta, Bergsagel, P Leif, Roccaro, Aldo M, Azzi, Jamil, Ghobrial, Irene M

“…Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive…”
Get full text

Abstract 3168: Tumor cells express genome-derived DNA in the cytosol by Shen, Yu J., Bert, Nina L., Koo, Christine X., Samantha, Ho S., Ishii, Ken J., Raulet, David H., Gasser, Stephan

“…Type I interferons (IFNs) are secreted by infected cells in response to the recognition of nucleic acids. DNA damage and the ensuing DNA damage response also…”
Get full text

RAE-1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma by Lam, Adeline R, Bert, Nina Le, Ho, Samantha SW, Shen, Yu J, Tang, Li FM, Xiong, Gordon M, Croxford, John L, Koo, Christine X, Ishii, Ken J, Akira, Shizuo, Raulet, David H, Gasser, Stephan

“…The immunoreceptor NKG2D originally identified in natural killer cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands…”
Get full text

A submatrix-based P300 brain-computer interface stimulus presentation paradigm by Shi, Jin-he, Shen, Ji-zhong, Ji, Yu, Du, Feng-lei

“…The P300 event-related potential (ERP), with advantages of high stability and no need for initial training, is one of the most commonly used responses in…”
Get full text