Search Results - "SHEN, Guoxiang"

FDA Approval Summary: Entrectinib for the Treatment of NTRK gene Fusion Solid Tumors by Marcus, Leigh, Donoghue, Martha, Aungst, Stephanie, Myers, Claire E, Helms, Whitney S, Shen, Guoxiang, Zhao, Hong, Stephens, Olen, Keegan, Patricia, Pazdur, Richard

“…The FDA-approved entrectinib on August 15, 2019, for the treatment of adult and pediatric patients 12 years of age and older with solid tumors that have a…”
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Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters by Shen, Guoxiang, Kong, Ah-Ng

“…The nuclear transcription factor E2‐related factor 2 (Nrf2) has been shown to play pivotal roles in preventing xenobiotic‐related toxicity and…”
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Suppression of NF-κB and NF-κB-regulated gene expression by sulforaphane and PEITC through IκBα, IKK pathway in human prostate cancer PC-3 cells by CHANGJIANG XU, GUOXIANG SHEN, CHI CHEN, GELINAS, Céline, KONG, Ah-Ng Tony

“…Recent studies indicate that natural isothiocyanates, such as sulforaphane (SFN) and phenethyl isothiocyanate (PEITC) possess strong antitumor activities in…”
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FDA Approval Summary: Daratumumab for Treatment of Multiple Myeloma After One Prior Therapy by Bhatnagar, Vishal, Gormley, Nicole J., Luo, Lola, Shen, Yuan Li, Sridhara, Rajeshwari, Subramaniam, Sriram, Shen, Guoxiang, Ma, Lian, Shord, Stacy, Goldberg, Kirsten B., Farrell, Ann T., McKee, Amy E., Pazdur, Richard

“…On November 21, 2016, the U.S. Food and Drug Administration granted regular approval to daratumumab in combination with lenalidomide and dexamethasone, or…”
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Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 by Xu, Changjiang, Huang, Mou-Tuan, Shen, Guoxiang, Yuan, Xiaoling, Lin, Wen, Khor, Tin Oo, Conney, Allan H, Kong, Ah-Ng Tony

“…Sulforaphane, a dietary isothiocyanate, possesses potent chemopreventive effects through the induction of cellular detoxifying/antioxidant enzymes via the…”
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Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism by Yu, Siwang, Shen, Guoxiang, Khor, Tin Oo, Kim, Jung-Hwan, Kong, Ah-Ng Tony

“…Akt/mammalian target of rapamycin (mTOR) signaling plays an important role in tumorigenesis and is dysregulated in many tumors, especially metastatic prostate…”
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Mechanical-thermal coupling fatigue failure of CoCrFeMnNi high entropy alloy by Li, Chaofan, Ma, Zhichao, Tong, Shuai, Liu, Jize, Zhang, Wei, Shen, Guoxiang, Wang, Shenghui, Zhao, Hongwei, Ren, Luquan

“…High entropy alloys exhibit excellent performance under different-temperature conditions. In order to investigate the effect of temperature on the…”
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Revealing low temperature-mechanical coupling failure mechanisms in CFRP laminates with in-situ observations by Li, Jiakai, Sun, Yang, Yang, Siguo, Han, Zhengchen, Shen, Guoxiang, Ma, Zhichao, Zhao, Hongwei, Ren, Luquan

“…The number of layers and ply orientations determined the service performance of carbon fiber-reinforced polymer (CFRP) materials. Under low-temperature service…”
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Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily by Schroeder, Gretchen M, An, Yongmi, Cai, Zhen-Wei, Chen, Xiao-Tao, Clark, Cheryl, Cornelius, Lyndon A. M, Dai, Jun, Gullo-Brown, Johnni, Gupta, Ashok, Henley, Benjamin, Hunt, John T, Jeyaseelan, Robert, Kamath, Amrita, Kim, Kyoung, Lippy, Jonathan, Lombardo, Louis J, Manne, Veeraswamy, Oppenheimer, Simone, Sack, John S, Schmidt, Robert J, Shen, Guoxiang, Stefanski, Kevin, Tokarski, John S, Trainor, George L, Wautlet, Barri S, Wei, Donna, Williams, David K, Zhang, Yingru, Zhang, Yueping, Fargnoli, Joseph, Borzilleri, Robert M

“…Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides were identified as potent and selective…”
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Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2 by Xu, Changjiang, Yuan, Xiaoling, Pan, Zui, Shen, Guoxiang, Kim, Jung-Hwan, Yu, Siwang, Khor, Tin Oo, Li, Wenge, Ma, Jianjie, Kong, Ah-Ng Tony

“…The up-regulation of phase II detoxifying and stress-responsive genes is believed to play an important role in cancer prevention, and many natural compounds…”
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Mechanical-thermal coupling structural failure and in-situ deformation mechanism of cellular high entropy alloy lattice structures by Tong, Shuai, Shen, Guoxiang, Han, Zhengchen, Ma, Zhichao, Sun, Yang, Guan, Shanyue, Zhao, Hongwei, Ren, Luquan, Yan, Chuliang

“…To investigate the effect of temperature on the compressive strength of CoCrFeMnNi high entropy alloy with lattice structures prepared by powder bed fusion,…”
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Pharmacokinetics and Pharmacodynamics of Broccoli Sprouts on the Suppression of Prostate Cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice: Implication of Induction of Nrf2, HO-1 and Apoptosis and the Suppression of Akt-dependent Kinase Pathway by Keum, Young-Sam, Oo Khor, Tin, Lin, Wen, Shen, Guoxiang, Han Kwon, Ki, Barve, Avantika, Li, Wenge, Kong, Ah-Ng

“…Purpose In the present study, we have evaluated the pharmacokinetics and the in vivo prostate chemopreventive activity of broccoli sprouts. Methods The in vivo…”
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Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable by Hu, Rong, Khor, Tin Oo, Shen, Guoxiang, Jeong, Woo-Sik, Hebbar, Vidya, Chen, Chi, Xu, Changjiang, Reddy, Bandaru, Chada, Kiran, Kong, Ah-Ng Tony

“…Sulforaphane (SFN) is an isothiocyanate that is present abundantly in widely consumed cruciferous vegetables and has a particularly high content in broccoli…”
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Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals by Chen, Chi, Pung, Daniel, Leong, Vasco, Hebbar, Vidya, Shen, Guoxiang, Nair, Sujit, Li, Wenge, Tony Kong, A.-N.

“…Garlic organosulfur compounds (OSCs) are recognized as a group of potential chemopreventive compounds. It is known that garlic OSCs can modulate drug…”
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p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1 by GUOXIANG SHEN, CHANGJIANG XU, CHI CHEN, HEBBAR, Vidya, KONG, Ah-Ng Tony

“…Isothiocyanate sulforaphane (SFN) is a potent cancer chemopreventive agent. We investigated the mechanisms underlying the anti-proliferative effects of SFN in…”
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Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice by TIN OO KHOR, KEUM, Young-Sam, CONNEY, Allan H, KONG, Ah-Ng Tony, WEN LIN, KIM, Jung-Hwan, RONG HU, GUOXIANG SHEN, CHANGJIANG XU, GOPALAKRISHNAN, Avanthika, REDDY, Bandaru, XI ZHENG

“…Earlier studies using prostate cancer cells in culture showed that phenethyl isothiocyanate (PEITC) and curcumin have significant chemopreventive and possibly…”
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ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells by Xu, Changjiang, Shen, Guoxiang, Yuan, Xiaoling, Kim, Jung-hwan, Gopalkrishnan, Avantika, Keum, Young-Sam, Nair, Sujit, Kong, Ah-Ng Tony

“…Many isothiocyanates (ITCs) such as sulforaphane (SFN), phenethyl isothiocyanate (PEITC) and allyl isothiocyanate (AITC) are highly effectively in…”
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Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells by Chen, Chi, Shen, Guoxiang, Hebbar, Vidya, Hu, Rong, Owuor, Edward D., Kong, A.-N.Tony

“…Epigallocatechin-3-gallate (EGCG), a major component in green tea polyphenols, has been proven to suppress colonic tumorigenesis in animal models and…”
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Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin by Shen, Guoxiang, Xu, Changjiang, Hu, Rong, Jain, Mohit R, Gopalkrishnan, Avantika, Nair, Sujit, Huang, Mou-Tuan, Chan, Jefferson Y, Kong, Ah-Ng Tony

“…Curcumin has been shown to prevent and inhibit carcinogen-induced tumorigenesis in different organs of rodent carcinogenesis models. Our objective is to study…”
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Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice by Shen, Guoxiang, Xu, Changjiang, Hu, Rong, Jain, Mohit R, Nair, Sujit, Lin, Wen, Yang, Chung S, Chan, Jefferson Y, Kong, A-N Tony

“…This study was conducted to study global gene expression profiles elicited by (-)-epigallocatechin-3-gallate (EGCG) in mouse liver and small intestine, as well…”
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