Search Results - "SHEINER, L"

Learning versus confirming in clinical drug development by Sheiner, Lewis B.

“…Clinical Pharmacology & Therapeutics (1997) 61, 275–291; doi:…”
Get full text

Pharmacokinetic/pharmacodynamic modeling in drug development by Sheiner, L B, Steimer, J L

“…We propose a framework for considering the role of pharmacokinetic/pharmacodynamic modeling in drug development and an appraisal of its current and potential…”
Get full text

Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check by Yano, Y, Beal, S L, Sheiner, L B

“…The posterior predictive check (PPC) is a model evaluation tool. It assigns a value (pPPC) to the probability that the value of a given statistic computed from…”
Get full text

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer by Bruno, R, Hille, D, Riva, A, Vivier, N, ten Bokkel Huinnink, W W, van Oosterom, A T, Kaye, S B, Verweij, J, Fossella, F V, Valero, V, Rigas, J R, Seidman, A D, Chevallier, B, Fumoleau, P, Burris, H A, Ravdin, P M, Sheiner, L B

“…The population pharmacokinetic/pharmacodynamic (PK/PD) approach was prospectively integrated in the clinical development of docetaxel to assess the PK profile…”
Get more information

The importance of modeling interoccasion variability in population pharmacokinetic analyses by Karlsson, M O, Sheiner, L B

“…Individual pharmacokinetic parameters may change randomly between study occasions. Analysis of simulated data with NONMEM shows that ignoring such…”
Get more information

Intention-to-treat analysis and the goals of clinical trials by Sheiner, L B, Rubin, D B

Get more information

A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data by Sheiner, L B

“…A clinical trial of an analgesic agent compares pain relief scores (ordered categorical responses) over time among groups of patients, each subject to a…”
Get more information

Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial by KASTRISSIOS, H, SUAREZ, J.-R, KATZENSTEIN, D, GIRARD, P, SHEINER, L. B, BLASCHKE, T. F

“…To characterize drug-taking behavior using continuous electronic monitoring in an AIDS clinical trial. This was a substudy of AIDS Clinical Trials Group (ACTG)…”
Get full text

Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships by Gupta, Suneel K., Sathyan, Gayatri, Lindemulder, Elizabeth A., Ho, Pai‐Ling, Sheiner, Lewis B., Aarons, Leon

“…Background Describing a therapeutic index for a drug is important for evaluating safe and effective dosage regimens. Therapeutic index can be evaluated as the…”
Get full text

Population modelling in drug development by Sheiner, L., Wakefield, J.

“…In this paper we discuss the vital role that population (hierarchical) modelling can play within the drug development process. Specifically, population…”
Get full text

A Markov mixed effect regression model for drug compliance by Girard, Pascal, Blaschke, Terrence F., Kastrissios, Helen, Sheiner, Lewis B.

“…Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal…”
Get full text

Population Pharmacokinetics of Nevirapine, Zidovudine, and Didanosine in Human Immunodeficiency Virus-Infected Patients by ZHOU, X.-J, SHEINER, L. B, D'AQUILA, R. T, HUGHES, M. D, HIRSCH, M. S, FISCHL, M. A, JOHNSON, V. A, MYERS, M, SOMMADOSSI, J.-P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Population Pharmacokinetics and Pharmacodynamics of Efavirenz, Nelfinavir, and Indinavir: Adult AIDS Clinical Trial Group Study 398 by PFISTER, Marc, LABBE, Line, HAMMER, Scott M, MELLORS, John, BENNETT, Kara K, ROSENKRANZ, Susan, SHEINER, Lewis B

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Structural insight into the apicomplexan drug target cytochrome bc1 by Maclean, A, Muhleip, A, Sheiner, L

Get full text

A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses: the antiemetic effect of ondansetron by Cox, E H, Veyrat-Follet, C, Beal, S L, Fuseau, E, Kenkare, S, Sheiner, L B

“…This paper presents and illustrates methodology for specifying, estimating, and evaluating a predictive model for repeated measures time-to-event responses…”
Get full text

The intellectual health of clinical drug evaluation by Sheiner, L B

Get more information

The need for mixed-effects modeling with population dichotomous data by Yano, I, Beal, S L, Sheiner, L B

“…Over the past 25 years sophisticated data analytic techniques have been developed which can lead to improved analyses, but at additional computational cost. In…”
Get full text

Pharmacokinetic-pharmacodynamic modelling of magnesium plasma concentration and blood pressure in preeclamptic women by JIANFENG LU, PFISTER, Marc, FERRARI, Paolo, GANG CHEN, SHEINER, Lewis

“…To describe the relationship between plasma magnesium (Mg(2+)) concentration and blood pressure response in pregnant women with preeclampsia. Fifty-one…”
Get full text

Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy by VANHOVE, G. F, GRIES, J.-M, VEROTTA, D, SHEINER, L. B, COOMBS, R, COLLIER, A. C, BLASCHKE, T. F

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

Pharmacodynamic model of tolerance: application to nicotine by Porchet, H C, Benowitz, N L, Sheiner, L B

“…The authors propose a model of pharmacodynamic response that, when integrated with a pharmacokinetic model, allows characterization of the development of…”
Get more information