Search Results - "SHEFNER, J"

Multipoint incremental motor unit number estimation as an outcome measure in ALS by SHEFNER, J. M, WATSON, M. L, SIMIONESCU, L, CARESS, J. B, BURNS, T. M, MARAGAKIS, N. J, BENATAR, M, DAVID, W. S, SHARMA, K. R, RUTKOVE, S. B

“…Improved outcome measures are necessary to reduce sample size and increase power in amyotrophic lateral sclerosis (ALS) clinical trials. Motor unit number…”
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Assessment of bulbar function in amyotrophic lateral sclerosis: validation of a self‐report scale (Center for Neurologic Study Bulbar Function Scale) by Smith, R. A., Macklin, E. A., Myers, K. J., Pattee, G. L., Goslin, K. L., Meekins, G. D., Green, J. R., Shefner, J. M., Pioro, E. P.

“…Background and purpose Impaired bulbar functions of speech and swallowing are among the most serious consequences of amyotrophic lateral sclerosis (ALS)…”
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A clinical trial of creatine in ALS by SHEFNER, J. M, CUDKOWICZ, M. E, CARESS, J, DONOFRIO, P, SORENSON, E, BRADLEY, W, LOMEN-HOERTH, C, PIORO, E, REZANIA, K, ROSS, M, PASCUZZI, R, HEIMAN-PATTERSON, T, SCHOENFELD, D, TANDAN, R, MITSUMOTO, H, ROTHSTEIN, J, SMITH-PALMER, T, MACDONALD, D, BURKE, D, CONRAD, T, TAFT, J, CHILTON, M, URBINELLI, L, QURESHI, M, ZHANG, H, PESTRONK, A

“…Mitochondrial dysfunction occurs early in the course of ALS, and the mitochondria may be an important site for therapeutic intervention. Creatine stabilizes…”
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The use of statistical MUNE in a multicenter clinical trial by Shefner, J. M., Cudkowicz, M. E., Zhang, H., Schoenfeld, D., Jillapalli, D.

“…Techniques to estimate motor unit number (MUNE) measure the number of functioning motor units in a muscle. In diseases characterized by progressive motor unit…”
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Functional outcome measures as clinical trial endpoints in ALS by Traynor, B J, Zhang, H, Shefner, J M, Schoenfeld, D, Cudkowicz, M E

“…The topiramate study was a 12-month randomized placebo-controlled trial in patients with ALS. Follow-up evaluation of the placebo group (n = 97) constituted a…”
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Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS by FERRANTE, K. L, SHEFNER, J, NEWHALL, K, DONOFRIO, P, CARESS, J, ASHBURN, C, FREIBERG, B, O'NEILL, C, PALADENECH, C, WALKER, T, PESTRONK, A, ABRAMS, B, ZHANG, H, FLORENCE, J, RENNA, R, SCHIERBECKER, J, MALKUS, B, CUDKOWICZ, M, BETENSKY, R, O'BRIEN, M, YU, H, FANTASIA, M, TAFT, J, BEAL, M. F, TRAYNOR, B

“…An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in…”
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Revised statistical motor unit number estimation in the Celecoxib/ALS trial by Shefner, J. M., Cudkowicz, M. E., Zhang, H., Schoenfeld, D., Jillapalli, D.

“…Techniques to estimate motor unit number (MUNE) measure the number of functioning motor units in a muscle. As amyotrophic lateral sclerosis (ALS) is…”
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Monkey median nerve repaired by nerve graft or collagen nerve guide tube by Archibald, SJ, Shefner, J, Krarup, C, Madison, RD

“…Nerve regeneration was followed in 15 median and 1 ulnar nerve of eight Macaca fascicularis monkeys by serial electrophysiological assessments over a period of…”
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Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy by SHEFNER, J. M, REAUME, A. G, FLOOD, D. G, SCOTT, R. W, KOWALL, N. W, FERRANTE, R. J, SIWEK, D. F, UPTON-RICE, M, BROWN, R. H

“…To characterize the motor neuron dysfunction in two models by performing physiologic and morphometric studies. Mutations in the gene encoding cytosolic…”
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Motor unit number estimation in human neurological diseases and animal models by Shefner, Jeremy M.

“…Motor unit number estimation (MUNE) was introduced in 1971 as a way of providing an objective and meaningful estimate of axon loss in diseases affecting the…”
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Lead exposure as a risk factor for amyotrophic lateral sclerosis by Kamel, F, Umbach, D M, Hu, H, Munsat, T L, Shefner, J M, Taylor, J A, Sandler, D P

“…The etiology of amyotrophic lateral sclerosis (ALS) likely involves an environmental component. We qualitatively assessed literature on ALS and lead exposure…”
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A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis by Cudkowicz, M E, Shefner, J M, Schoenfeld, D A, Brown, Jr, R H, Johnson, H, Qureshi, M, Jacobs, M, Rothstein, J D, Appel, S H, Pascuzzi, R M, Heiman-Patterson, T D, Donofrio, P D, David, W S, Russell, J A, Tandan, R, Pioro, E P, Felice, K J, Rosenfeld, J, Mandler, R N, Sachs, G M, Bradley, W G, Raynor, E M, Baquis, G D, Belsh, J M, Novella, S, Goldstein, J, Hulihan, J

“…To determine if long-term topiramate therapy is safe and slows disease progression in patients with ALS. A double-blind, placebo-controlled, multicenter…”
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Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations by SHEFNER, J. M, BROWN, R. H, COLE, D, CHATURVEDI, P, SCHOENFELD, D, PASTUSZAK, K, MATTHEWS, R, UPTON-RICE, M, CUDKOWICZ, M. E

“…Mice with trangenes that express mutations in the gene for cytosolic copper/zinc superoxide dismutase (SOD1) develop motor neuron degeneration resembling human…”
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Reducing intersubject variability in motor unit number estimation by Shefner, Jeremy M., Jillapalli, Devanand, Bradshaw, Deborah Y.

“…Motor unit number estimation (MUNE) attempts to directly assess the number of functioning motor units present in a muscle. It is an important addition to the…”
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Ulnar neuropathy at the elbow by Bradshaw, D Y, Shefner, J M

“…Among the entrapment neuropathies, ulnar neuropathy at the elbow is second only to carpal tunnel syndrome in frequency; however, diagnosis and management are…”
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Ulnar neuropathy and dystonic flexion of the fourth and fifth digits: Clinical correlation in musicians by Charness, Michael E., Ross, Marjorie H., Shefner, Jeremy M.

“…Peripheral nerve lesions are sometimes associated with focal dystonia. We diagnosed ulnar neuropathy in 28 of 73 (40%) cases of occupational cramp in…”
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Recurrent inhibition is decreased in patients with amyotrophic lateral sclerosis by RAYNOR, E. M, SHEFNER, J. M

“…Recurrent inhibitory pathways are powerful modulators of motor neuron excitability. Renshaw cell activation can both inhibit homologous motor neurons and…”
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Immunotoxin therapy of small-cell lung cancer: a phase I study of N901-blocked ricin by Lynch, Jr, T J, Lambert, J M, Coral, F, Shefner, J, Wen, P, Blattler, W A, Collinson, A R, Ariniello, P D, Braman, G, Cook, S, Esseltine, D, Elias, A, Skarin, A, Ritz, J

“…Immunotoxins could improve outcome in small-cell lung cancer (SCLC) by targeting tumor cells that are resistant to chemotherapy and radiation. N901 is a murine…”
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The cutaneous silent period is mediated by spinal inhibitory reflex by Logigian, Eric L., Plotkin, George M., Shefner, Jeremy M.

“…High‐intensity cutaneous stimuli inhibit tonically firing motor neurons resulting in a silent period (CSP) in EMG activity. To determine the central nervous…”
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Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosis by Longnecker, M P, Kamel, F, Umbach, D M, Munsat, T L, Shefner, J M, Lansdell, L W, Sandler, D P

“…Dietary factors have long been suspected of being risk factors for amyotrophic lateral sclerosis (ALS), but few human studies have been reported. To address…”
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