Search Results - "SHEEHAN, Katherine"

Methods in cardiomyocyte isolation, culture, and gene transfer by Louch, William E, Sheehan, Katherine A, Wolska, Beata M

“…Abstract Since techniques for cardiomyocyte isolation were first developed 35 years ago, experiments on single myocytes have yielded great insight into their…”
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Use of Artificial Intelligence in Improving Outcomes in Heart Disease: A Scientific Statement From the American Heart Association by Armoundas, Antonis A, Narayan, Sanjiv M, Arnett, Donna K, Spector-Bagdady, Kayte, Bennett, Derrick A, Celi, Leo Anthony, Friedman, Paul A, Gollob, Michael H, Hall, Jennifer L, Kwitek, Anne E, Lett, Elle, Menon, Bijoy K, Sheehan, Katherine A, Al-Zaiti, Salah S

“…A major focus of academia, industry, and global governmental agencies is to develop and apply artificial intelligence and other advanced analytical tools to…”
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Protective role for caspase-11 during acute experimental murine colitis by Oficjalska, Katarzyna, Raverdeau, Mathilde, Aviello, Gabriella, Wade, Siobhan C, Hickey, Ana, Sheehan, Katherine M, Corr, Sinead C, Kay, Elaine W, O'Neill, Luke A, Mills, Kingston H G, Creagh, Emma M

“…Activation of the noncanonical inflammasome, mediated by caspase-11, serves as an additional pathway for the production of the proinflammatory cytokines IL-1β…”
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Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer by Mezynski, M Janusz, Farrelly, Angela M, Cremona, Mattia, Carr, Aoife, Morgan, Clare, Workman, Julie, Armstrong, Paul, McAuley, Jennifer, Madden, Stephen, Fay, Joanna, Sheehan, Katherine M, Kay, Elaine W, Holohan, Ciara, Elamin, Yasir, Rafee, Shereen, Morris, Patrick G, Breathnach, Oscar, Grogan, Liam, Hennessy, Bryan T, Toomey, Sinead

“…Aberrant PI3K signalling is implicated in trastuzumab resistance in HER2-positive gastric cancer (GC). The role of PI3K or MEK inhibitors in sensitising…”
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Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy by Bleach, Rachel, Madden, Stephen F, Hawley, James, Charmsaz, Sara, Selli, Cigdem, Sheehan, Katherine M, Young, Leonie S, Sims, Andrew H, Souček, Pavel, Hill, Arnold D, McIlroy, Marie

“…There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal…”
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Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings by Leech, Astrid O, Vellanki, Sri HariKrishna, Rutherford, Emily J, Keogh, Aoife, Jahns, Hanne, Hudson, Lance, O'Donovan, Norma, Sabri, Siham, Abdulkarim, Bassam, Sheehan, Katherine M, Kay, Elaine W, Young, Leonie S, Hill, Arnold D K, Smith, Yvonne E, Hopkins, Ann M

“…Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer…”
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Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies by Toomey, Sinead, Eustace, Alexander J, Fay, Joanna, Sheehan, Katherine M, Carr, Aoife, Milewska, Malgorzata, Madden, Stephen F, Teiserskiene, Ausra, Kay, Elaine W, O'Donovan, Norma, Gallagher, William, Grogan, Liam, Breathnach, Oscar, Walshe, Janice, Kelly, Catherine, Moulton, Brian, Kennedy, M John, Gullo, Guiseppe, Hill, Arnold D, Power, Colm, Duke, Deirdre, Hambly, Niamh, Crown, John, Hennessy, Bryan T

“…The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and…”
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Development, Validation, and Clinical Utility of a Six-gene Signature to Predict Aggressive Prostate Cancer by Krzyzanowska, Agnieszka, Barron, Stephen, Higgins, Debra F., Loughman, Tony, O'Neill, Amanda, Sheehan, Katherine, Wang, Chan-Ju Angel, Fender, Bozena, McGuire, Leah, Fay, Joanna, O'Grady, Anthony, O'Leary, Des, William Watson, R., Bjartell, Anders, Gallagher, William M.

“…In this study, we developed a six-gene signature in radical prostatectomy tissue from men with prostate cancer and validated it in an independent cohort. The…”
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Prognostic value of the 6-gene OncoMasTR test in hormone receptor–positive HER2-negative early-stage breast cancer: Comparative analysis with standard clinicopathological factors by Lynch, Seodhna M., Russell, Niamh M., Barron, Stephen, Wang, Chan-Ju A., Loughman, Tony, Dynoodt, Peter, Fender, Bozena, Lopez-Ruiz, Cesar, O'Grady, Anthony, Sheehan, Katherine M., Fay, Joanna, Amberger-Murphy, Verena, Saha, Anurati, Klinger, Rut, Gonzalez, Claudia A., Al-Attar, Nebras, Rahman, Arman, O'Leary, Desmond, Lanigan, Fiona T., Bracken, Adrian P., Crown, John, Kelly, Catherine M., O'Connor, Darran P., Gallagher, William M.

“…The aim of the study was to assess the prognostic performance of a 6-gene molecular score (OncoMasTR Molecular Score [OMm]) and a composite risk score…”
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Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment by Fitzgerald, Seán, Espina, Virginia, Liotta, Lance, Sheehan, Katherine M, O'Grady, Anthony, Cummins, Robert, O'Kennedy, Richard, Kay, Elaine W, Kijanka, Gregor S

“…Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes…”
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Use of Reverse Phase Protein Microarrays and Reference Standard Development for Molecular Network Analysis of Metastatic Ovarian Carcinoma by Sheehan, Katherine M, Calvert, Valerie S, Kay, Elaine W, Lu, Yiling, Fishman, David, Espina, Virginia, Aquino, Joy, Speer, Runa, Araujo, Robyn, Mills, Gordon B, Liotta, Lance A, Petricoin, 3rd, Emanuel F, Wulfkuhle, Julia D

“…Cancer can be defined as a deregulation or hyperactivity in the ongoing network of intracellular and extracellular signaling events. Reverse phase protein…”
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Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A by Taglieri, Domenico M, Monasky, Michelle M, Knezevic, Ivana, Sheehan, Katherine A, Lei, Ming, Wang, Xin, Chernoff, Jonathan, Wolska, Beata M, Ke, Yunbo, Solaro, R. John

“…Abstract Earlier investigations in our lab indicated an anti-adrenergic effect induced by activation of p21-activated kinase (Pak-1) and protein phosphatase 2A…”
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ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis by Charmsaz, Sara, Doherty, Ben, Cocchiglia, Sinéad, Varešlija, Damir, Marino, Attilio, Cosgrove, Nicola, Marques, Ricardo, Priedigkeit, Nolan, Purcell, Siobhan, Bane, Fiona, Bolger, Jarlath, Byrne, Christopher, O'Halloran, Philip J, Brett, Francesca, Sheehan, Katherine, Brennan, Kieran, Hopkins, Ann M, Keelan, Stephen, Jagust, Petra, Madden, Stephen, Martinelli, Chiara, Battaglini, Matteo, Oesterreich, Steffi, Lee, Adrian V, Ciofani, Gianni, Hill, Arnold D K, Young, Leonie S

“…Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast…”
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Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients by Fitzgerald, Seán, Sheehan, Katherine M, O'Grady, Anthony, Kenny, Dermot, O'Kennedy, Richard, Kay, Elaine W, Kijanka, Gregor S

“…Background and Aim TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in…”
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Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1 by DeSantiago, Jaime, Bare, Dan J, Ke, Yunbo, Sheehan, Katherine A, Solaro, R. John, Banach, Kathrin

“…Abstract p21-activated kinase (Pak1), a serine-threonine protein kinase, regulates cytoskeletal dynamics and cell motility. Recent experiments further…”
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Genomic and Transcriptomic Characterisation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer by Toomey, Sinead, Gunther, Jillian, Carr, Aoife, Weksberg, David C., Thomas, Valentina, Salvucci, Manuela, Bacon, Orna, Sherif, El-Masry, Fay, Joanna, Kay, Elaine W., Sheehan, Katherine M., McNamara, Deborah A., Sanders, Keith L, Mathew, Geena, Breathnach, Oscar S., Grogan, Liam, Morris, Patrick G., Foo, Wai C., You, Yi-Qian N., Prehn, Jochen H., O’Neill, Brian, Krishnan, Sunil, Hennessy, Bryan T., Furney, Simon J.

“…Standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (NACRT), followed by surgical resection. However, >70% of…”
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Development of a Novel Weighted Ranking Method for Immunohistochemical Quantification of a Heterogeneously Expressed Protein in Gastro-Esophageal Cancers by Richards, Cathy E, Sheehan, Katherine M, Kay, Elaine W, Hedner, Charlotta, Borg, David, Fay, Joanna, O'Grady, Anthony, Hill, Arnold D K, Jirström, Karin, Hopkins, Ann M

“…High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the…”
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Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys by Ortiz, Alexandra M, Carnathan, Diane G, Yu, Joana, Sheehan, Katherine M, Kim, Peter, Reynaldi, Arnold, Vanderford, Thomas H, Klatt, Nichole R, Brenchley, Jason M, Davenport, Miles P, Silvestri, Guido

“…Aberrant turnover of memory CD4+ T-cells is central to Acquired Immunodeficiency Syndrome (AIDS) progression. Understanding the relationship between the…”
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p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility by Sheehan, Katherine A, Ke, Yunbo, Solaro, R John

“…We review here a novel concept in the regulation of cardiac contractility involving variations in the activity of the multifunctional enzyme, p21-activated…”
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GLUT‐1 expression and response to chemoradiotherapy in rectal cancer by Brophy, Sarah, Sheehan, Katherine M., McNamara, Deborah A., Deasy, Joseph, Bouchier‐Hayes, David J., Kay, Elaine W.

“…Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do…”
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