Search Results - "SHEARER, Todd W"

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model by Price, Daniel J., Drewry, David H., Schaller, Lee T., Thompson, Brian D., Reid, Paul R., Maloney, Patrick R., Liang, Xi, Banker, Periette, Buckholz, Richard G., Selley, Paula K., McDonald, Octerloney B., Smith, Jeffery L., Shearer, Todd W., Cox, Richard F., Williams, Shawn P., Reid, Robert A., Tacconi, Stefano, Faggioni, Federico, Piubelli, Chiara, Sartori, Ilaria, Tessari, Michela, Wang, Tony Y.

“…[Display omitted] Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients…”
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Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats by Stimpson, Stephen A, Turner, Scott M, Clifton, Lisa G, Poole, James C, Mohammed, Hussein A, Shearer, Todd W, Waitt, Greg M, Hagerty, Laura L, Remlinger, Katja S, Hellerstein, Marc K, Evans, William J

“…There is currently no direct, facile method to determine total-body skeletal muscle mass for the diagnosis and treatment of skeletal muscle wasting conditions…”
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Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists by Evans, Karen A, Budzik, Brian W, Ross, Sean A, Wisnoski, David D, Jin, Jian, Rivero, Ralph A, Vimal, Mythily, Szewczyk, George R, Jayawickreme, Channa, Moncol, David L, Rimele, Thomas J, Armour, Susan L, Weaver, Susan P, Griffin, Robert J, Tadepalli, Sarva M, Jeune, Michael R, Shearer, Todd W, Chen, Zibin B, Chen, Lihong, Anderson, Donald L, Becherer, J. David, De Los Frailes, Maite, Colilla, Francisco Javier

“…A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent small molecule agonists of the human TGR5…”
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Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines by DIAZ, Damaris S, KOZAR, Michael. P, SMITH, Kirsten S, ASHER, Constance O, SOUSA, Jason C, SCHIEHSER, Guy A, JACOBUS, David. P, MILHOUS, Wilbur. K, SKILLMAN, Donald. R, SHEARER, Todd. W

“…Phenoxypropoxybiguanides, such as PS-15, are antimalarial prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil. Unlike…”
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In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines by Shearer, Todd. W, Kozar, Michael. P, O'Neil, Michael T, Smith, Philip L, Schiehser, Guy A, Jacobus, David. P, Diaz, Damaris S, Yang, Young-Sun, Milhous, Wilbur. K, Skillman, Donald. R

“…Phenoxypropoxybiguanides, such as 1 (PS-15), are prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil. Unlike cycloguanil,…”
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Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT) by Deng, Hongfeng, O’Keefe, Heather, Davie, Christopher P, Lind, Kenneth E, Acharya, Raksha A, Franklin, G. Joseph, Larkin, Jonathan, Matico, Rosalie, Neeb, Michael, Thompson, Monique M, Lohr, Thomas, Gross, Jeffrey W, Centrella, Paolo A, O’Donovan, Gary K, Bedard, Katie L. (Sargent), van Vloten, Kurt, Mataruse, Sibongile, Skinner, Steven R, Belyanskaya, Svetlana L, Carpenter, Tiffany Y, Shearer, Todd W, Clark, Matthew A, Cuozzo, John W, Arico-Muendel, Christopher C, Morgan, Barry A

“…The metalloprotease ADAMTS-5 is considered a potential target for the treatment of osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed…”
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Discovery of 4‑Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38 by Becherer, J. David, Boros, Eric E., Carpenter, Tiffany Y., Cowan, David J., Deaton, David N., Haffner, Curt D., Jeune, Michael R., Kaldor, Istvan W., Poole, J. Chuck, Preugschat, Frank, Rheault, Tara R., Schulte, Christie A., Shearer, Barry G., Shearer, Todd W., Shewchuk, Lisa M., Smalley, Terrence L., Stewart, Eugene L., Stuart, J. Darren, Ulrich, John C.

“…Starting from the micromolar 8-quinoline carboxamide high-throughput screening hit 1a, a systematic exploration of the structure–activity relationships (SAR)…”
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Pharmacokinetics, Safety, and Hydrolysis of Oral Pyrroloquinazolinediamines Administered in Single and Multiple Doses in Rats by QIGUI LI, KOZAR, Michael P, SKILLMAN, Donald R, SHEARER, Todd W, XIE, Lisa H, LIN, Ai J, SMITH, Kirsten S, YUANZHENG SI, ANOVA, Lalaine, JING ZHANG, MILHOUS, Wilbur K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats by Shankaran, Mahalakshmi, Shearer, Todd W, Stimpson, Stephen A, Turner, Scott M, King, Chelsea, Wong, Po-Yin Anne, Shen, Ying, Turnbull, Philip S, Kramer, Fritz, Clifton, Lisa, Russell, Alan, Hellerstein, Marc K, Evans, William J

“…Biomarkers of muscle protein synthesis rate could provide early data demonstrating anabolic efficacy for treating muscle-wasting conditions. Androgenic…”
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Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D3-creatine dilution method by Stimpson, Stephen A., Leonard, Michael S., Clifton, Lisa G., Poole, James C., Turner, Scott M., Shearer, Todd W., Remlinger, Katja S., Clark, Richard V., Hellerstein, Marc K., Evans, William J.

“…Background We recently validated in cross-sectional studies a new method to determine total body creatine pool size and skeletal muscle mass based on D 3…”
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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist by Shearer, Barry G, Wiethe, Robert W, Ashe, Adam, Billin, Andrew N, Way, James M, Stanley, Thomas B, Wagner, Craig D, Xu, Robert X, Leesnitzer, Lisa M, Merrihew, Raymond V, Shearer, Todd W, Jeune, Michael R, Ulrich, John C, Willson, Timothy M

“…4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a potent and selective ligand for PPARδ with good…”
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Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D 3 -creatine dilution method by Stimpson, Stephen A, Leonard, Michael S, Clifton, Lisa G, Poole, James C, Turner, Scott M, Shearer, Todd W, Remlinger, Katja S, Clark, Richard V, Hellerstein, Marc K, Evans, William J

“…We recently validated in cross-sectional studies a new method to determine total body creatine pool size and skeletal muscle mass based on D -creatine dilution…”
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Adenosine A1 Receptor Modulation of MMP-2 Secretion by Trabecular Meshwork Cells by Shearer, Todd W, Crosson, Craig E

“…Studies have shown that adenosine A(1) agonists can lower IOP in rabbits, mice, and monkeys, and this response is mediated in part by increases in outflow…”
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Bradykinin enhancement of PGE2 signalling in bovine trabecular meshwork cells by WEBB, Jerry G, SHEARER, Todd W, YATES, Phillip W, MUKHIN, Yurii V, CROSSON, Craig E

“…Kinins and prostaglandins activate signalling pathways in cells of the trabecular meshwork and have opposing effects on outflow resistance to aqueous humor…”
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The role of in vitro ADME assays in antimalarial drug discovery and development by Shearer, Todd W, Smith, Kirsten S, Diaz, Damaris, Asher, Constance, Ramirez, Julio

“…The high level of attrition of drugs in clinical development has led pharmaceutical companies to increase the efficiency of their lead identification and…”
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Longitudinal determination of total body creatine pool size and skeletal muscle mass in rats by D 3 ‐creatine dilution by Stimpson, Stephen A., Leonard, Michael S., Clifton, Lisa G., Poole, James C., Turner, Scott M., Shearer, Todd W., Remlinger, Katja S., Clark, Richard V., Hellerstein, Marc K., Evans, William J.

“…Abstract only We recently described a new method to determine total body creatine pool size and skeletal muscle mass based on dilution of an oral dose of D 3…”
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Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-d3) dilution in rats by STIMPSON, Stephen A, TURNER, Scott M, EVANS, William J, CLIFTON, Lisa G, POOLE, James C, MOHAMMED, Hussein A, SHEARER, Todd W, WAITT, Greg M, HAGERTY, Laura L, REMLINGER, Katja S, HELLERSTEIN, Marc K

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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethylbenzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist by SHEARER, Barry G, WIETHE, Robert W, SHEARER, Todd W, JEUNE, Michael R, ULRICH, John C, WILLSON, Timothy M, ASHE, Adam, BILLIN, Andrew N, WAY, James M, STANLEY, Thomas B, WAGNER, Craig D, XU, Robert X, LEESNITZER, Lisa M, MERRIHEW, Raymond V

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Bradykinin enhancement of PGE 2 signalling in bovine trabecular meshwork cells by Webb, Jerry G., Shearer, Todd W., Yates, Phillip W., Mukhin, Yurii V., Crosson, Craig E.

“…Kinins and prostaglandins activate signalling pathways in cells of the trabecular meshwork and have opposing effects on outflow resistance to aqueous humor…”
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Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist by Ignar, Diane M, Goetz, Aaron S, Noble, Kimberly Nichols, Carballo, Luz Helena, Stroup, Andrea E, Fisher, Julie C, Boucheron, Joyce A, Brainard, Tracy A, Larkin, Andrew L, Epperly, Andrea H, Shearer, Todd W, Sorensen, Scott D, Speake, Jason D, Hommel, Jonathan D

“…μ-Opioid receptor (MOR) agonism induces palatable food consumption principally through modulation of the rewarding properties of food…”
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