Search Results - "SHCHERBAKOVA, Polina V"

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme by Xing, Xuanxuan, Kane, Daniel P., Bulock, Chelsea R., Moore, Elizabeth A., Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V.

“…Alterations in the exonuclease domain of DNA polymerase ε (Polε) cause ultramutated tumors. Severe mutator effects of the most common variant, Polε-P286R,…”
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Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity by Mertz, Tony M., Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V.

“…Significance Mutations affecting replicative DNA polymerases δ (Polδ) and ε (Polε) are linked to sporadic and hereditary colorectal cancer and sporadic…”
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Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε by Parkash, Vimal, Kulkarni, Yashraj, ter Beek, Josy, Shcherbakova, Polina V., Kamerlin, Shina Caroline Lynn, Johansson, Erik

“…The most frequently recurring cancer-associated DNA polymerase ε (Pol ε) mutation is a P286R substitution in the exonuclease domain. While originally proposed…”
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Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae by Barbari, Stephanie R, Kane, Daniel P, Moore, Elizabeth A, Shcherbakova, Polina V

“…DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and postreplicative DNA mismatch repair…”
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DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors by Ostroverkhova, Daria, Tyryshkin, Kathrin, Beach, Annette K., Moore, Elizabeth A., Masoudi-Sobhanzadeh, Yosef, Barbari, Stephanie R., Rogozin, Igor B., Shaitan, Konstantin V., Panchenko, Anna R., Shcherbakova, Polina V.

“…Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers. These cancers accumulate AGA>ATA transversions; however, their genomic…”
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DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA by Kochenova, Olga V, Daee, Danielle L, Mertz, Tony M, Shcherbakova, Polina V

“…Translesion synthesis (TLS) helps cells to accomplish chromosomal replication in the presence of unrepaired DNA lesions. In eukaryotes, the bypass of most…”
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Role of DNA Polymerases in Repeat-Mediated Genome Instability by Shah, Kartik A., Shishkin, Alexander A., Voineagu, Irina, Pavlov, Youri I., Shcherbakova, Polina V., Mirkin, Sergei M.

“…Expansions of simple DNA repeats cause numerous hereditary diseases in humans. We analyzed the role of DNA polymerases in the instability of Friedreich’s…”
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A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability by Kadyrova, Lyudmila Y, Mertz, Tony M, Zhang, Yu, Northam, Matthew R, Sheng, Ziwei, Lobachev, Kirill S, Shcherbakova, Polina V, Kadyrov, Farid A

“…Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of…”
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cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability by Daee, Danielle L, Mertz, Tony M, Shcherbakova, Polina V

“…Accurate DNA synthesis by the replicative DNA polymerases α, δ, and ε is critical for genome stability in eukaryotes. In humans, over 20 SNPs were reported…”
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Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy by Barbari, Stephanie R., Shcherbakova, Polina V.

“…The fidelity of DNA replication relies on three error avoidance mechanisms acting in series: nucleotide selectivity of replicative DNA polymerases,…”
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A Common Cancer-Associated DNA Polymerase ε Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading by KANE, Daniel P, SHCHERBAKOVA, Polina V

“…Exonucleolytic proofreading and DNA mismatch repair (MMR) act in series to maintain high-fidelity DNA replication and to avoid mutagenesis. MMR defects elevate…”
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DNA polymerase δ proofreads errors made by DNA polymerase ε by Bulock, Chelsea R., Xing, Xuanxuan, Shcherbakova, Polina V.

“…During eukaryotic replication, DNA polymerases ε (Polε) and δ (Polδ) synthesize the leading and lagging strands, respectively. In a long-known contradiction to…”
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Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant by Bulock, Chelsea R, Xing, Xuanxuan, Shcherbakova, Polina V

“…Substitutions in the exonuclease domain of DNA polymerase ϵ cause ultramutated human tumors. Yeast and mouse mimics of the most common variant, P286R, produce…”
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Translesion synthesis DNA polymerases and control of genome stability by Shcherbakova, Polina V, Fijalkowska, Iwona J

“…Eukaryotic and prokaryotic genomes are replicated with amazingly high fidelity to assure faithful transmission of genetic information from one generation to…”
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Enhanced polymerase activity permits efficient synthesis by cancer-Associated DNA polymerase variants at low dNTP levels by Barbari, Stephanie R., Beach, Annette K., Markgren, Joel G., Parkash, Vimal, Moore, Elizabeth A., Johansson, Erik, Shcherbakova, Polina V

“…Amino acid substitutions in the exonuclease domain of DNA polymerase (Pol) cause ultramutated tumors. Studies in model organisms suggested pathogenic…”
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Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae by Northam, Matthew R, Robinson, Heather A, Kochenova, Olga V, Shcherbakova, Polina V

“…Translesion synthesis DNA polymerases contribute to DNA damage tolerance by mediating replication of damaged templates. Due to the low fidelity of these…”
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Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28 by Stepchenkova, Elena I, Zhuk, Anna S, Cui, Jian, Tarakhovskaya, Elena R, Barbari, Stephanie R, Shcherbakova, Polina V, Polev, Dmitrii E, Fedorov, Roman, Poliakov, Eugenia, Rogozin, Igor B, Lada, Artem G, Pavlov, Youri I

“…Abstract Current eukaryotic replication models postulate that leading and lagging DNA strands are replicated predominantly by dedicated DNA polymerases. The…”
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DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures by Northam, Matthew R, Moore, Elizabeth A, Mertz, Tony M, Binz, Sara K, Stith, Carrie M, Stepchenkova, Elena I, Wendt, Kathern L, Burgers, Peter M J, Shcherbakova, Polina V

“…DNA polymerase ζ (Pol ζ) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol ζ can also participate in replication of undamaged DNA when…”
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Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations by Kochenova, Olga V, Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V, Chabes, Andrei, Burgers, Peter M J, Shcherbakova, Polina V

“…In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects…”
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Differential ATP Binding and Intrinsic ATP Hydrolysis by Amino-terminal Domains of the Yeast Mlh1 and Pms1 Proteins by Hall, Mark C., Shcherbakova, Polina V., Kunkel, Thomas A.

“…MutL homologs belong to a family of proteins that share a conserved ATP binding site. We demonstrate that amino-terminal domains of the yeast MutL homologs…”
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