Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men: HIV affects the immune system before CD4+ T helper cell depletion occurs

To investigate the effect of persistent HIV infection on the immune system, we studied leukocyte functions in 14 asymptomatic homosexual men (CDC group II/III) who were at least two years seropositive, but who still had normal numbers of circulating CD4+ T cells. Compared with age-matched heterosexu...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 82; no. 6; pp. 1908 - 1914
Main Authors:	MIEDEMA, F, PETIT, A. J. C, SCHELLEKENS, P. T. A, TERPSTRA, F. G, SHCATTENKERK, J. K. M. E, DE WOLF, F, AL, B. J. M, ROOS, M, LANGE, J. M A, DANNER, S. A, GOUDSMIT, J
Format:	Journal Article
Language:	English
Published:	Ann Arbor, MI American Society for Clinical Investigation 01-12-1988
Subjects:	Acquired Immunodeficiency Syndrome - immunology AIDS/HIV Antigens, Differentiation, T-Lymphocyte - analysis B-Lymphocytes - immunology B-Lymphocytes - pathology Biological and medical sciences CD8 Antigens Cell Differentiation Cell Division HIV Seropositivity Homosexuality Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Male Medical sciences T-Lymphocytes - pathology T-Lymphocytes, Helper-Inducer - immunology Human Immunopathology Homosexuality Seropositivity Monocyte Pathogenesis Retroviridae AIDS Asymptomatic Hemopathy Vaccine Cell subpopulation Infection Virus B»-Lymphocyte Immunological investigation Viral disease T-Lymphocyte Human immunodeficiency virus
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Summary:	To investigate the effect of persistent HIV infection on the immune system, we studied leukocyte functions in 14 asymptomatic homosexual men (CDC group II/III) who were at least two years seropositive, but who still had normal numbers of circulating CD4+ T cells. Compared with age-matched heterosexual men and HIV-negative homosexual men, the CD4+ and CD8+ T cells from seropositive men showed decreased proliferation to anti-CD3 monoclonal antibody and decreased CD4+ T-helper activity on PWM-driven differentiation of normal donor B cells. Monocytes of HIV-infected homosexual men showed decreased accessory function on normal T cell proliferation induced by CD3 monoclonal antibody. The most striking defect in leukocyte functional activities was observed in the B cells of HIV-infected men. B cells of 13 out of 14 seropositive men failed to produce Ig in response to PWM in the presence of adequate allogeneic T-helper activity. These findings suggest that HIV induces severe immunological abnormalities in T cells, B cells, and antigen-presenting cells early in infection before CD4+ T cell numbers start to decline. Impaired immunological function in subclinically HIV-infected patients may have clinical implications for vaccination strategies, in particular the use of live vaccines in groups with a high prevalence of HIV seropositivity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9738 1558-8238
DOI:	10.1172/JCI113809