Search Results - "SHAYAKHMETOV, Dmitry M"

Innate immunity to adenovirus: lessons from mice by Atasheva, Svetlana, Yao, Jia, Shayakhmetov, Dmitry M.

“…Adenovirus is a highly evolutionary successful pathogen, as it is widely prevalent across the animal kingdom, infecting hosts ranging from lizards and frogs to…”
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Cytokine Responses to Adenovirus and Adenovirus Vectors by Atasheva, Svetlana, Shayakhmetov, Dmitry M

“…The expression of cytokines and chemokines in response to adenovirus infection is tightly regulated by the innate immune system. Cytokine-mediated toxicity and…”
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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death by Weng, Dan, Marty-Roix, Robyn, Ganesan, Sandhya, Proulx, Megan K., Vladimer, Gregory I., Kaiser, William J., Mocarski, Edward S., Pouliot, Kimberly, Chan, Francis Ka-Ming, Kelliher, Michelle A., Harris, Phillip A., Bertin, John, Gough, Peter J., Shayakhmetov, Dmitry M., Goguen, Jon D., Fitzgerald, Katherine A., Silverman, Neal, Lien, Egil

“…A number of pathogens cause host cell death upon infection, and Yersinia pestis , infamous for its role in large pandemics such as the “Black Death” in…”
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Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection by Di Paolo, Nelson C., Shafiani, Shahin, Day, Tracey, Papayannopoulou, Thalia, Russell, David W., Iwakura, Yoichiro, Sherman, David, Urdahl, Kevin, Shayakhmetov, Dmitry M.

“…The interleukin-1 receptor I (IL-1RI) is critical for host resistance to Mycobacterium tuberculosis (Mtb), yet the mechanisms of IL-1RI-mediated pathogen…”
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Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus by Wagner, Nicole, Shayakhmetov, Dmitry M, Stewart, Phoebe L

“…Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5,…”
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Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice by Cassel, Suzanne L., Janczy, John R., Bing, Xinyu, Wilson, Shruti P., Olivier, Alicia K., Otero, Jesse E., lwakura, Yoichiro, Shayakhmetov, Dmitry M., Bassuk, Alexander G., Abu-Amer, Yousef, Brogden, Kim A., Burns, Trudy L., Sutterwala, Fayyaz S., Ferguson, Polly J.

“…Chronic recurrent multifocal osteomyelitis (CRMO) is a human autoinflammatory disorder that primarily affects bone. Missense mutation (L98P) of…”
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Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus by Doronin, Konstantin, Flatt, Justin W., Di Paolo, Nelson C., Khare, Reeti, Kalyuzhniy, Oleksandr, Acchione, Mauro, Sumida, John P., Ohto, Umeharu, Shimizu, Toshiyuki, Akashi-Takamura, Sachiko, Miyake, Kensuke, MacDonald, James W., Bammler, Theo M., Beyer, Richard P., Farin, Frederico M., Stewart, Phoebe L., Shayakhmetov, Dmitry M.

“…Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher…”
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Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells by Lee, Woojong, Kingstad-Bakke, Brock, Paulson, Brett, Larsen, Autumn, Overmyer, Katherine, Marinaik, Chandranaik B, Dulli, Kelly, Toy, Randall, Vogel, Gabriela, Mueller, Katherine P, Tweed, Kelsey, Walsh, Alex J, Russell, Jason, Saha, Krishanu, Reyes, Leticia, Skala, Melissa C, Sauer, John-Demian, Shayakhmetov, Dmitry M, Coon, Joshua, Roy, Krishnendu, Suresh, M

“…There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report that…”
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p38MAPK guards the integrity of endosomal compartments through regulating necrotic death by Yao, Jia, Atasheva, Svetlana, Toy, Randall, Blanchard, Emmeline L., Santangelo, Philip J., Roy, Krishnendu, Mocarski, Edward S., Shayakhmetov, Dmitry M.

“…Pathogens trigger activation of sensors of the innate immune system that initiate molecular signaling enabling appropriate host defense programs. Although…”
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The Transcription Factor IRF3 Triggers “Defensive Suicide” Necrosis in Response to Viral and Bacterial Pathogens by Di Paolo, Nelson C., Doronin, Konstantin, Baldwin, Lisa K., Papayannopoulou, Thalia, Shayakhmetov, Dmitry M.

“…Although molecular components that execute noninflammatory apoptotic cell death are well defined, molecular pathways that trigger necrotic cell death remain…”
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Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity by SHAYAKHMETOV, Dmitry M, GAGGAR, Anuj, SHAOHENG NI, LI, Zong-Yi, LIEBER, André

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IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells by Di Paolo, Nelson C, Baldwin, Lisa K, Irons, Eric E, Papayannopoulou, Thalia, Tomlinson, Stephen, Shayakhmetov, Dmitry M

“…Inflammation is a highly coordinated host response to infection, injury, or cell stress. In most instances, the inflammatory response is pro-survival and is…”
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Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes by Parker, Alan L., Waddington, Simon N., Nicol, Campbell G., Shayakhmetov, Dmitry M., Buckley, Suzanne M., Denby, Laura, Kemball-Cook, Geoffrey, Ni, Shaoheng, Lieber, Andre, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor (CAR) for cell binding and αv integrins for internalization. When…”
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Interleukin 1α and the inflammatory process by Di Paolo, Nelson C, Shayakhmetov, Dmitry M

“…IL-1α is a ubiquitously expressed cytokine that has diverse roles in immunity and homeostasis. Di Paolo and Shayakhmetov review IL-1α's distinctive and…”
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Redundant and Synergistic Mechanisms Control the Sequestration of Blood-born Adenovirus in the Liver by Di Paolo, Nelson C, van Rooijen, Nico, Shayakhmetov, Dmitry M

“…Human adenovirus (Ad) is a ubiquitous pathogen causing a wide range of diseases. Although the interactions of human Ad serotype 5 (Ad5) with susceptible cells…”
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Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors by Shayakhmetov, Dmitry M, Di Paolo, Nelson C, Mossman, Karen L

“…The innate immune and inflammatory response represents one of the key stumbling blocks limiting the efficacy of viral-based therapies. Numerous human diseases…”
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Coagulation Factor Binding Orientation and Dimerization May Influence Infectivity of Adenovirus-Coagulation Factor Complexes by Irons, Eric E, Flatt, Justin W, Doronin, Konstantin, Fox, Tara L, Acchione, Mauro, Stewart, Phoebe L, Shayakhmetov, Dmitry M

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Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors by SHAYAKHMETOV, Dmitry M, LI, Zong-Yi, SHAOHENG NI, LIEBER, André

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Interleukin-1 Receptor 2 Keeps the Lid on Interleukin-1α by Di Paolo, Nelson C., Shayakhmetov, Dmitry M.

“…The molecular mechanisms that regulate functional activation of IL-1α remain elusive. In this issue of Immunity, Zheng et al. (2013) describe a molecular…”
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Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo by Ciraci, Ceren, Janczy, John R, Jain, Nidhi, Haasken, Stefanie, Pecli E Silva, Cyntia, Benjamim, Claudia F, Sadler, Jeffrey J, Olivier, Alicia K, Iwakura, Yoichiro, Shayakhmetov, Dmitry M, Sutterwala, Fayyaz S, Cassel, Suzanne L

“…The precise context in which the innate immune system is activated plays a pivotal role in the subsequent instruction of CD4+ T helper (Th) cell responses. Th1…”
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