Search Results - "SHAW, Lynn C"

Inflammation in the pathogenesis of microvascular complications in diabetes by Nguyen, Dung V, Shaw, Lynn C, Grant, Maria B

“…Diabetes and hyperglycemia create a proinflammatory microenvironment that progresses to microvascular complications such as nephropathy, retinopathy, and…”
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Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow by BHATWADEKAR, Ashay D, YUANQING YAN, BOULTON, Michael E, GRANT, Maria B, XIAOPING QI, THINSCHMIDT, Jeffrey S, NEU, Matthew B, LI CALZI, Sergio, SHAW, Lynn C, DOMINIGUEZ, James M, BUSIK, Julia V, LEE, Choogon

“…In this study, we assessed whether Per2 clock gene-mutant mice exhibit a vascular phenotype similar to diabetes. Per2 (B6.129-Per2(tm1Drw)/J) or wild-type…”
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Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes by HAZRA, Sugata, RASHEED, Adil, WEIDONG WANG, THINSCHMIDT, Jeffrey S, VERMA, Amrisha, QIUHONG LI, LEVI, Moshe, CUMMINS, Carolyn L, GRANT, Maria B, BHATWADEKAR, Ashay, XIAOXIN WANG, SHAW, Lynn C, PATEL, Monika, CABALLERO, Sergio, MAGOMEDOVA, Lilia, SOLIS, Nathaniel, YUANQING YAN

“…Endothelial progenitor cells (EPCs), critical for mediating vascular repair, are dysfunctional in a hyperglycemic and/or hypercholesterolemic environment…”
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Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes by SEGAL, Mark S, SHAH, Ronak, TRAN-SON-TAY, Roger, GRANT, Maria B, AFZAL, Aqeela, PERRAULT, Cecile M, CHANG, Kyunghee, SCHULER, Anna, BEEM, Elaine, SHAW, Lynn C, CALZI, Sergio Li, HARRISON, Jeffrey K

“…Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes Mark S. Segal 1 , Ronak Shah 1…”
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EPCs and pathological angiogenesis: When good cells go bad by Calzi, Sergio Li, Neu, Matthew B., Shaw, Lynn C., Kielczewski, Jennifer L., Moldovan, Nicanor I., Grant, Maria B.

“…Bone-marrow-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated pathological neovascularization, and recent studies have begun to…”
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Bone marrow-CNS connections: Implications in the pathogenesis of diabetic retinopathy by Yellowlees Douglas, Jane, Bhatwadekar, Ashay D., Li Calzi, Sergio, Shaw, Lynn C., Carnegie, Debra, Caballero, Sergio, Li, Quihong, Stitt, Alan W., Raizada, Mohan K., Grant, Maria B.

“…Diabetic retinopathy is the fourth most common cause of blindness in adults. Current therapies, including anti-VEGF therapy, have partial efficacy in arresting…”
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IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development by Chang, Kyung-Hee, Chan-Ling, Tailoi, McFarland, Evan L, Afzal, Aqeela, Pan, Hao, Baxter, Louise C, Shaw, Lynn C, Caballero, Sergio, Sengupta, Nilanjana, Calzi, Sergio Li, Sullivan, Sean M, Grant, Maria B

“…We asked whether the hypoxia-regulated factor, insulin-like growth factor binding protein-3 (IGFBP3), could modulate stem cell factor receptor (c-kit⁺), stem…”
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Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3 by Jarajapu, Yagna P R, Cai, Jun, Yan, Yuanqing, Li Calzi, Sergio, Kielczewski, Jennifer L, Hu, Ping, Shaw, Lynn C, Firth, Sue M, Chan-Ling, Tailoi, Boulton, Michael E, Baxter, Robert C, Grant, Maria B

“…Previously, we showed that insulin growth factor (IGF)-1 binding protein-3 (IGFBP-3), independent of IGF-1, reduces pathological angiogenesis in a mouse model…”
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The role of growth factors in the pathogenesis of diabetic retinopathy by Grant, Maria B, Afzal, Aqeela, Spoerri, Polyxenie, Pan, Hao, Shaw, Lynn C, Mames, Robert N

“…Diabetic retinopathy (DR) is the most severe of several ocular complications of diabetes. The earliest clinical signs of DR are microaneurysms and…”
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Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization by Sengupta, Nilanjana, Afzal, Aqeela, Caballero, Sergio, Chang, Kyung-Hee, Shaw, Lynn C, Pang, Ji-Jing, Bond, Vincent C, Bhutto, Imran, Baba, Takayuki, Lutty, Gerard A, Grant, Maria B

“…Modulators of angiogenesis typically work in an orchestrated manner. The authors examined the interaction between insulinlike growth factor (IGF)-1, vascular…”
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Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model by Jacobsen, Max H., Salazar, Tatiana, Shaw, Lynn C., March, Keith, Raizada, Mohan K., Pepine, Carl J., Katovich, Michael J., Grant, Maria B., Rathinasabapathy, Anandharajan, Espejo, Andrew, Yan, Yuanqing, Shenoy, Vinayak, Zhang, Juan, Della Rocca, Domenico G., Cook, Todd, Li Calzi, Sergio, Sandusky, George E.

“…We compared the functional outcome of Isl-1+ cardiac progenitors, CD90+ bone marrow-derived progenitor cells, and the combination of the two in a rat…”
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Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and ERK activation through α5β1 Integrin and PI 3-kinase by WILSON, Sylvia H, LJUBILMOV, Alexander V, MORTAL, Alex O, CABALLERO, Sergio, SHAW, Lynn C, SPOERRI, Polyxenie E, TARNUZZER, Roy W, GRANT, Maria B

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Molecular Targeting of Antiangiogenic Factor 16K hPRL Inhibits Oxygen-Induced Retinopathy in Mice by Pan, Hao, Nguyen, Ngoc-Quynh-Nhu, Yoshida, Hiroshi, Bentzien, Frauke, Shaw, Lynn C, Rentier-Delrue, Francoise, Martial, Joseph A, Weiner, Richard, Struman, Ingrid, Grant, Maria B

“…To examine the ability and mechanism of the 16 kDa N-terminal fragment of human prolactin (16K hPRL) in the inhibition of abnormal retinal neovascularization…”
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Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina by Hu, Ping, Hunt, Nicholas H, Arfuso, Frank, Shaw, Lynn C, Uddin, Mohammad Nasir, Zhu, Meidong, Devasahayam, Raj, Adamson, Samuel J, Benson, Vicky L, Chan-Ling, Tailoi, Grant, Maria B

“…We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the…”
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Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) model by Li Calzi, Sergio, Shaw, Lynn C, Moldovan, Leni, Shelley, William C, Qi, Xiaoping, Racette, Lyne, Quigley, Judith L, Fortmann, Seth D, Boulton, Michael E, Yoder, Mervin C, Grant, Maria B

“…Retinopathy of prematurity (ROP) is a disorder of the developing retina of preterm infants. ROP can lead to blindness because of abnormal angiogenesis that is…”
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Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation by Kielczewski, Jennifer L, Jarajapu, Yagna P.R, McFarland, Evan L, Cai, Jun, Afzal, Aqeela, Li Calzi, Sergio, Chang, Kyung Hee, Lydic, Todd, Shaw, Lynn C, Busik, Julia, Hughes, Jeffrey, Cardounel, Arturo J, Wilson, Kenneth, Lyons, Timothy J, Boulton, Michael E, Mames, Robert N, Chan-Ling, Tailoi, Grant, Maria B

“…RATIONALE:Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior,…”
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Novel Protective Properties of IGFBP-3 Result in Enhanced Pericyte Ensheathment, Reduced Microglial Activation, Increased Microglial Apoptosis, and Neuronal Protection after Ischemic Retinal Injury by Kielczewski, Jennifer L, Hu, Ping, Shaw, Lynn C, Li Calzi, Sergio, Mames, Robert N, Gardiner, Tom A, McFarland, Evan, Chan-Ling, Tailoi, Grant, Maria B

“…This study was conducted to determine the perivascular cell responses to increased endothelial cell expression of insulin-like growth factor binding protein-3…”
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Cell-Based Therapies for Diabetic Retinopathy by Shaw, Lynn C., Neu, Matthew B., Grant, Maria B.

“…Autologous endothelial progenitor cell (EPC) populations represent a novel treatment for therapeutic revascularization and vascular repair for diabetic…”
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An ocular view of the IGF–IGFBP system by Nguyen, Dung V, Li Calzi, Sergio, Shaw, Lynn C, Kielczewski, Jennifer L, Korah, Hannah E, Grant, Maria B

“…Abstract IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have…”
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Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase) by Kielczewski, Jennifer L, Li Calzi, Sergio, Shaw, Lynn C, Cai, Jun, Qi, Xiaoping, Ruan, Qing, Wu, Lin, Liu, Li, Hu, Ping, Chan-Ling, Tailoi, Mames, Robert N, Firth, Sue, Baxter, Robert C, Turowski, Patric, Busik, Julia V, Boulton, Michael E, Grant, Maria B

“…To examine the effect of free insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), independent of the effect of insulin-like growth factors, in…”
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