Search Results - "SHAW, Lindsey N"

Small things considered: the small accessory subunits of RNA polymerase in Gram-positive bacteria by Weiss, Andy, Shaw, Lindsey N.

“…The DNA-dependent RNA polymerase core enzyme in Gram-positive bacteria consists of seven subunits. Whilst four of them (α2ββ′) are essential, three smaller…”
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Staphopains Modulate Staphylococcus aureus Biofilm Integrity by Mootz, Joe M, Malone, Cheryl L, Shaw, Lindsey N, Horswill, Alexander R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mycobacterium abscessus DosRS two-component system controls a species-specific regulon required for adaptation to hypoxia by Simcox, Breven S, Tomlinson, Brooke R, Shaw, Lindsey N, Rohde, Kyle H

“…( ), an emerging opportunistic pathogen, predominantly infects individuals with underlying pulmonary diseases such as cystic fibrosis (CF). Current treatment…”
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The novel two-component system AmsSR governs alternative metabolic pathway usage in Acinetobacter baumannii by Casella, Leila G, Torres, Nathanial J, Tomlinson, Brooke R, Shepherd, Mark, Shaw, Lindsey N

“…In this study, we identify a novel two-component system in (herein named AmsSR for regulator of alternative metabolic systems) only present in select…”
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Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation by Beenken, Karen E, Mrak, Lara N, Griffin, Linda M, Zielinska, Agnieszka K, Shaw, Lindsey N, Rice, Kelly C, Horswill, Alexander R, Bayles, Kenneth W, Smeltzer, Mark S

“…The accessory gene regulator (agr) and staphylococcal accessory regulator (sarA) play opposing roles in Staphylococcus aureus biofilm formation. There is…”
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Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors by Koziel, Joanna, Maciag-Gudowska, Agnieszka, Mikolajczyk, Tomasz, Bzowska, Malgorzata, Sturdevant, Daniel E, Whitney, Adeline R, Shaw, Lindsey N, DeLeo, Frank R, Potempa, Jan

“…It is becoming increasingly apparent that Staphylococcus aureus are able to survive engulfment by macrophages, and that the intracellular environment of these…”
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Coordinated adaptation of Staphylococcus aureus to calprotectin-dependent metal sequestration by Reyes Ruiz, Valeria M, Freiberg, Jeffrey A, Weiss, Andy, Green, Erin R, Jobson, Mary-Elizabeth, Felton, Emily, Shaw, Lindsey N, Chazin, Walter J, Skaar, Eric P

“…The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through metal sequestration in a process known as "nutritional immunity."…”
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Galectin-3 Is a Target for Proteases Involved in the Virulence of Staphylococcus aureus by Elmwall, Jonas, Kwiecinski, Jakub, Na, Manli, Ali, Abukar Ahmed, Osla, Veronica, Shaw, Lindsey N, Wang, Wanzhong, Sävman, Karin, Josefsson, Elisabet, Bylund, Johan, Jin, Tao, Welin, Amanda, Karlsson, Anna

“…is a major cause of skin and soft tissue infection. The bacterium expresses four major proteases that are emerging as virulence factors: aureolysin (Aur), V8…”
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Unraveling the Impact of Secreted Proteases on Hypervirulence in Staphylococcus aureus by Gimza, Brittney D, Jackson, Jessica K, Frey, Andrew M, Budny, Bridget G, Chaput, Dale, Rizzo, Devon N, Shaw, Lindsey N

“…controls the progression of infection through the coordinated production of extracellular proteases, which selectively modulate virulence determinant…”
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Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants by Tsang, Laura H, Cassat, James E, Shaw, Lindsey N, Beenken, Karen E, Smeltzer, Mark S

“…Mutation of sarA in Staphylococcus aureus results in a reduced capacity to form a biofilm, but the mechanistic basis for this remains unknown. Previous…”
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Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus by Weiss, Andy, Fleeman, Renee M, Shaw, Lindsey N

“…In this issue of Cell Chemical Biology, Choby et al. (2016) use a small molecule inhibitor active against fermenting S. aureus to unravel a unique connection…”
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Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica by Bory, Alexandre, Shilling, Andrew J, Allen, Jessie, Azhari, Ala, Roth, Alison, Shaw, Lindsey N, Kyle, Dennis E, Adams, John H, Amsler, Charles D, McClintock, James B, Baker, Bill J

“…The Antarctic sponge is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of…”
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Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus by Boyd, Jeffrey M, Ryan Kaler, Kylie, Esquilín-Lebrón, Karla, Pall, Ashley, Campbell, Courtney J, Foley, Mary E, Rios-Delgado, Gustavo, Mustor, Emilee M, Stephens, Timothy G, Bovermann, Hannah, Greco, Todd M, Cristea, Ileana M, Carabetta, Valerie J, Beavers, William N, Bhattacharya, Debashish, Skaar, Eric P, Shaw, Lindsey N, Stemmler, Timothy L

“…Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe and the toxicity of non-chelated cytosolic ionic Fe,…”
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Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens by Fleeman, Renee M, Debevec, Ginamarie, Antonen, Kirsten, Adams, Jessie L, Santos, Radleigh G, Welmaker, Gregory S, Houghten, Richard A, Giulianotti, Marc A, Shaw, Lindsey N

“…We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this…”
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Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc by Balasubramanian, Divya, Ohneck, Elizabeth A, Chapman, Jessica, Weiss, Andy, Kim, Min Kyung, Reyes-Robles, Tamara, Zhong, Judy, Shaw, Lindsey N, Lun, Desmond S, Ueberheide, Beatrix, Shopsin, Bo, Torres, Victor J

“…Staphylococcus aureus is a formidable human pathogen that uses secreted cytolytic factors to injure immune cells and promote infection of its host. Of these…”
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Staphylococcal Proteases Aid in Evasion of the Human Complement System by Jusko, Monika, Potempa, Jan, Kantyka, Tomasz, Bielecka, Ewa, Miller, Halie K., Kalinska, Magdalena, Dubin, Grzegorz, Garred, Peter, Shaw, Lindsey N., Blom, Anna M.

“…Staphylococcus aureus is an opportunistic pathogen that presents severe health care concerns due to the prevalence of multiple antibiotic-resistant strains…”
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SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of Staphylococcus aureus LAC and UAMS-1 by Ramirez, Aura M., Beenken, Karen E., Byrum, Stephanie D., Tackett, Alan J., Shaw, Lindsey N., Gimza, Brittney D., Smeltzer, Mark S.

“…Using DNA affinity chromatography we demonstrate that the S. aureus regulatory proteins MgrA, Rot, SarA, and SarS bind DNA baits derived from the promoter…”
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Genome-wide Annotation, Identification, and Global Transcriptomic Analysis of Regulatory or Small RNA Gene Expression in Staphylococcus aureus by Carroll, Ronan K, Weiss, Andy, Broach, William H, Wiemels, Richard E, Mogen, Austin B, Rice, Kelly C, Shaw, Lindsey N

“…In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been identified, yet this class of molecule remains poorly understood and…”
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The identification of two M20B family peptidases required for full virulence in Staphylococcus aureus by Torres, Nathanial J, Rizzo, Devon N, Reinberg, Maria A, Jobson, Mary-Elizabeth, Totzke, Brendan C, Jackson, Jessica K, Yu, Wenqi, Shaw, Lindsey N

“…We have previously demonstrated that deletion of an intracellular leucine aminopeptidase results in attenuated virulence of . Herein we explore the role of 10…”
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Mapping the Global Network of Extracellular Protease Regulation in Staphylococcus aureus by Gimza, Brittney D, Larias, Maria I, Budny, Bridget G, Shaw, Lindsey N

“…A primary function of the extracellular proteases of is to control the progression of infection by selectively modulating the stability of virulence factors…”
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