Search Results - "SHAW, Jacqui"

A framework for the development of effective anti-metastatic agents by Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D., Ritchie, James W. A.

“…Most cancer-related deaths are a result of metastasis, and thus the importance of this process as a target of therapy cannot be understated. By asking ‘how can…”
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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA by Abbosh, Christopher, Frankell, Alexander M., Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa L., Weiss, Jakob, Schroeder, Morgan R., Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R. M., Martínez-Ruiz, Carlos, Bakir, Maise Al, Pich, Oriol, Watkins, Thomas B. K., Lim, Emilia L., Huebner, Ariana, Moore, David A., Godin-Heymann, Nadia, L’Hernault, Anne, Bye, Hannah, Odell, Aaron, Roberts, Paula, Gomes, Fabio, Patel, Akshay J., Manzano, Elizabeth, Hiley, Crispin T., Carey, Nicolas, Riley, Joan, Cook, Daniel E., Hodgson, Darren, Stetson, Daniel, Barrett, J. Carl, Kortlever, Roderik M., Evan, Gerard I., Hackshaw, Allan, Daber, Robert D., Shaw, Jacqui A., Aerts, Hugo J. W. L., Licon, Abel, Stahl, Josh, Jamal-Hanjani, Mariam, Birkbak, Nicolai J., McGranahan, Nicholas, Swanton, Charles

“…Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy 1 . The study of large patient…”
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A rapid RT-LAMP SARS-CoV-2 screening assay for collapsing asymptomatic COVID-19 transmission by Allsopp, Rebecca C, Cowley, Caroline M, Barber, Ruth C, Jones, Carolyn, Holmes, Christopher W, Bird, Paul W, Gohil, Shailesh G, Blackmore, Claire, Tobin, Martin D, Brunskill, Nigel, Baker, Philip N, Shaw, Jacqui A

“…To demonstrate the diagnostic performance of rapid SARS-CoV-2 RT-LAMP assays, comparing the performance of genomic versus sub-genomic sequence target with…”
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Comparison of microfluidic digital PCR and conventional quantitative PCR for measuring copy number variation by Whale, Alexandra S, Huggett, Jim F, Cowen, Simon, Speirs, Valerie, Shaw, Jacqui, Ellison, Stephen, Foy, Carole A, Scott, Daniel J

“…One of the benefits of Digital PCR (dPCR) is the potential for unparalleled precision enabling smaller fold change measurements. An example of an assessment…”
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Meta-Analysis of Circulating Tumor Cell PD-L1 Expression and the Association with Clinical Outcomes in Non-Small Cell Lung Cancer by Acheampong, Emmanuel, Allsopp, Rebecca C, Page, Karen, Wadsley, Marc K, Beasley, Aaron B, Coombes, R Charles, Shaw, Jacqui A, Gray, Elin S

“…Abstract Background Programmed death ligand-1 (PD-L1) expression on circulating tumor cells (CTCs) has been suggested to provide prognostic information in…”
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Opportunities and challenges of circulating biomarkers in neuroblastoma by Trigg, Ricky M, Shaw, Jacqui A, Turner, Suzanne D

“…Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and…”
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The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review by Cree, Ian A, Uttley, Lesley, Buckley Woods, Helen, Kikuchi, Hugh, Reiman, Anne, Harnan, Susan, Whiteman, Becky L, Philips, Sian Taylor, Messenger, Michael, Cox, Angela, Teare, Dawn, Sheils, Orla, Shaw, Jacqui

“…The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to…”
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Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma by Openshaw, Mark R., Suwaidan, Ali Abdulnabi, Ottolini, Barbara, Fernandez-Garcia, Daniel, Richards, Cathy J., Page, Karen, Guttery, David S., Thomas, Anne L., Shaw, Jacqui A.

“…Background Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as…”
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An optimised patient-derived explant platform for breast cancer reflects clinical responses to chemotherapy and antibody-directed therapy by Demetriou, Constantinos, Abid, Naila, Butterworth, Michael, Lezina, Larissa, Sandhu, Pavandeep, Howells, Lynne, Powley, Ian R., Pringle, James H., Sidat, Zahirah, Qassid, Omar, Purnell, Dave, Kaushik, Monika, Duckworth, Kaitlin, Hartshorn, Helen, Thomas, Anne, Shaw, Jacqui A., MacFarlane, Marion, Pritchard, Catrin, Miles, Gareth J.

“…Breast Cancer is the most common cancer among women globally. Despite significant improvements in overall survival, many tumours are refractory to therapy and…”
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How to design and implement a university-based COVID-19 testing programme? An evaluation of a novel RT-LAMP COVID-19 testing programme in a UK university by Blackmore, Claire, Hall, Gareth W, Allsopp, Rebecca C, Hansell, Anna L, Cowley, Caroline M, Barber, Ruth C, Holmes, Christopher W, Tobin, Martin D, Shaw, Jacqui A, Brunskill, Nigel J, Baker, Philip N

“…Little is known about how asymptomatic testing as a method to control transmission of COVID-19 can be implemented, and the prevalence of asymptomatic infection…”
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Mass spectrometric detection of KRAS protein mutations using molecular imprinting by Norman, Rachel L, Singh, Rajinder, Muskett, Frederick W, Parrott, Emma L, Rufini, Alessandro, Langridge, James I, Runau, Franscois, Dennison, Ashley, Shaw, Jacqui A, Piletska, Elena, Canfarotta, Francesco, Ng, Leong L, Piletsky, Sergey, Jones, Donald J L

“…Cancer is a disease of cellular evolution where single base changes in the genetic code can have significant impact on the translation of proteins and their…”
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Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer by Adamo, Patricia, Cowley, Caroline M, Neal, Christopher P, Mistry, Vilas, Page, Karen, Dennison, Ashley R, Isherwood, John, Hastings, Robert, Luo, JinLi, Moore, David A, Howard, Pringle J, Miguel, Martins L, Pritchard, Catrin, Manson, Margaret, Shaw, Jacqui A

“…The majority of pancreatic ductal adenocarcinomas (PDAC) are diagnosed late so that surgery is rarely curative. Earlier detection could significantly increase…”
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Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity by Myint, Ni Ni Moe, Verma, Ajay M., Fernandez-Garcia, Daniel, Sarmah, Panchali, Tarpey, Patrick S., Al-Aqbi, Saif Sattar, Cai, Hong, Trigg, Ricky, West, Kevin, Howells, Lynne M., Thomas, Anne, Brown, Karen, Guttery, David S., Singh, Baljit, Pringle, Howard J., McDermott, Ultan, Shaw, Jacqui A., Rufini, Alessandro

“…Improving early detection of colorectal cancer (CRC) is a key public health priority as adenomas and stage I cancer can be treated with minimally invasive…”
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Clonal evolution in the transition from cutaneous disease to acute leukemia suggested by liquid biopsy in blastic plasmacytoid dendritic cell neoplasm by Ladikou, Eleni, Ottolini, Barbara, Nawaz, Nadia, Allchin, Rebecca L, Payne, Daniel, Ali, Hebah, Marafioti, Teresa, Shaw, Jacqui, Ahearne, Matthew J, Wagner, Simon D

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Circulating tumor cells and plasma DNA analysis in patients with indeterminate early or metastatic breast cancer by Shaw, Jacqui A, Brown, James, Coombes, R Charles, Jacob, Jimmy, Payne, Rachel, Lee, Belinda, Page, Karen, Hava, Natasha, Stebbing, Justin

“…Circulating tumor cells (CTCs) and tumor-specific alterations in cell-free plasma DNA can both be used as markers of prognosis in breast cancer. To date, there…”
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Liquid biopsies: An introduction to circulating tumour cells and ctDNA by Shaw, Jacqui

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Integrating next generation sequencing into the clinic by Shaw, Jacqui, Cowley, Caroline

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Alpha-tocopherol supplementation does not affect monocyte endothelial adhesion or C-reactive protein levels but reduces soluble vascular adhesion molecule-1 in the plasma of healthy subjects by Woollard, Kevin J, Rayment, Sarah J, Bevan, Ruth, Shaw, Jacqui A, Lunec, Joseph, Griffiths, Helen R

“…Vascular monocyte retention in the subintima is pivotal to the development of cardiovascular disease and is facilitated by up-regulation of adhesion molecules…”
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Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution by Hiley, Crispin T., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Herrero, Javier, Swanton, Charles, Swanton, Charles, Czyzewska-Khan, Justyna, Gorman, Pat, Wilson, Gareth, Watkins, Thomas B.K., McGranahan, Nicholas, Mitter, Richard, Escudero, Mickael, Rowan, Andrew, Xu, Hang, Turajlic, Samra, Stone, Richard Kevin, Denner, Tamara, Costa, Marta, Phillimore, Ben, Joshi, Kroopa, Furness, Andrew, Ben Aissa, Assma, Wong, Yien Ning Sophia, Quezada, Sergio, Hartley, John A., Lowe, Helen L., Herrero, Javier, Lawrence, David, Falzon, Mary, Borg, Elaine, Marafioti, Teresa, Janes, Sam M., Thakrar, Ricky, Papadatos-Pastos, Dionysis, Choudhary, Junaid, Califano, Raffaele, Taylor, Paul, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Bishop, Paul, Chaturved, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Blackhall, Fiona, Chemi, Francesca, Gulati, Sakshi, Naidu, Babu, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Middleton, Gary, Shaw, Jacqui A., Le Quesne, John, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Riley, Joan, Primrose, Lindsay, Anand, Girija, Nicolson, Marianne, Palmer, Shirley, Buchan, Keith, Chetty, Mahendran, Edwards, Alison, Morgan, Fiona, Davies, Helen, Verjee, Azmina, MacKenzie, Mairead, Hackshaw, Allan, Smith, Sean, Alzetani, Aiman, Shaw, Emily, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Bhayani, Harshil, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-sellers, Melanie, Prakash, Vineet, Horey, Tracey, Hill, Jennifer, Suvarna, Kim, Keerio, Allah Dino, Feeney, Sarah, Asante-Siaw, Julius, Dessimoz, Christophe

“…Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion…”
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Effects of oral vitamin C on monocyte: endothelial cell adhesion in healthy subjects by Woollard, Kevin J, Loryman, Chris J, Meredith, Elizabeth, Bevan, Ruth, Shaw, Jacqui A, Lunec, Joe, Griffiths, Helen R

“…Monocyte recruitment and retention in the vasculature is influenced by oxidative stress and is involved in cardiovascular disease (CVD). Individuals with low…”
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