Search Results - "SHAUNAK, Sunil"

Cytotoxicity of polycations: Relationship of molecular weight and the hydrolytic theory of the mechanism of toxicity by Monnery, Bryn D., Wright, Michael, Cavill, Rachel, Hoogenboom, Richard, Shaunak, Sunil, Steinke, Joachim H.G., Thanou, Maya

“…[Display omitted] The mechanism of polycation cytotoxicity and the relationship to polymer molecular weight is poorly understood. To gain an insight into this…”
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Alternatives to antibiotics—a pipeline portfolio review by Czaplewski, Lloyd, Dr, Bax, Richard, MD, Clokie, Martha, Prof, Dawson, Mike, PhD, Fairhead, Heather, PhD, Fischetti, Vincent A, Prof, Foster, Simon, Prof, Gilmore, Brendan F, Prof, Hancock, Robert E W, Prof, Harper, David, PhD, Henderson, Ian R, Prof, Hilpert, Kai, PhD, Jones, Brian V, PhD, Kadioglu, Aras, Prof, Knowles, David, PhD, Ólafsdóttir, Sigríður, PhD, Payne, David, PhD, Projan, Steve, PhD, Shaunak, Sunil, Prof, Silverman, Jared, PhD, Thomas, Christopher M, Prof, Trust, Trevor J, PhD, Warn, Peter, PhD, Rex, John H, MD

“…Summary Antibiotics have saved countless lives and enabled the development of modern medicine over the past 70 years. However, it is clear that the success of…”
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Phagocytosis‐dependent activation of a TLR9–BTK–calcineurin–NFAT pathway co‐ordinates innate immunity to Aspergillus fumigatus by Herbst, Susanne, Shah, Anand, Mazon Moya, Maria, Marzola, Vanessa, Jensen, Barbara, Reed, Anna, Birrell, Mark A, Saijo, Shinobu, Mostowy, Serge, Shaunak, Sunil, Armstrong‐James, Darius

“…Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity…”
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Nebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis by Shirkhani, Khojasteh, PhD, Teo, Ian, PhD, Armstrong-James, Darius, MD, PhD, Shaunak, Sunil, MD, PhD

“…Abstract Aspergillus species are the major life threatening fungal pathogens in transplant patients. Germination of inhaled fungal spores initiates infection,…”
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Site-specific PEGylation of native disulfide bonds in therapeutic proteins by Shaunak, Sunil, Brocchini, Steve, Godwin, Antony, Choi, Ji-Won, Balan, Sibu, Pedone, Elisa, Vijayarangam, Damotharan, Heidelberger, Sibylle, Teo, Ian, Zloh, Mire

“…Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical…”
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Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses by Barata, Teresa S, Teo, Ian, Brocchini, Steve, Zloh, Mire, Shaunak, Sunil

“…The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available…”
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Site-Specific PEGylation of Protein Disulfide Bonds Using a Three-Carbon Bridge by Balan, Sibu, Choi, Ji-won, Godwin, Antony, Teo, Ian, Laborde, Carlos M, Heidelberger, Sibylle, Zloh, Mire, Shaunak, Sunil, Brocchini, Steve

“…The covalent conjugation of a functionalized poly(ethylene glycol) (PEG) to multiple nucleophilic amine residues results in a heterogeneous mixture of PEG…”
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A new and clinically relevant murine model of solid-organ transplant aspergillosis by Herbst, Susanne, Shah, Anand, Carby, Martin, Chusney, Gary, Kikkeri, Naresh, Dorling, Anthony, Bignell, Elaine, Shaunak, Sunil, Armstrong-James, Darius

“…Invasive fungal infections (IFIs) are a major cause of death in organ transplant patients. The murine hydrocortisone-mediated immunosuppression model of…”
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Perspective: Dendrimer drugs for infection and inflammation by Shaunak, Sunil

“…Biologists are dissecting complex biological pathways at breath taking speed. It is opening up new opportunities for the therapeutic evaluation of novel…”
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Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers by Teo, Ian, Toms, Steve M., Marteyn, Benoit, Barata, Teresa S., Simpson, Peter, Johnston, Karen A., Schnupf, Pamela, Puhar, Andrea, Bell, Tracey, Tang, Chris, Zloh, Mire, Matthews, Steve, Rendle, Phillip M., Sansonetti, Philippe J., Shaunak, Sunil

“…Intestinal pathogens use the host's excessive inflammatory cytokine response, designed to eliminate dangerous bacteria, to disrupt epithelial gut wall…”
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Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy by Stevenson, Mario, Sharkey, Mark E, Teo, Ian, Greenough, Thomas, Sharova, Natalia, Luzuriaga, Katherine, Sullivan, John L, Bucy, R. Pat, Kostrikis, Leondios G, Haase, Ashley, Veryard, Claire, Davaro, Raul E, Cheeseman, Sarah H, Daly, Jennifer S, Bova, Carol, Ellison, Richard T, Mady, Brian, Lai, Kwan Kew, Moyle, Graeme, Nelson, Mark, Gazzard, Brian, Shaunak, Sunil

“…Treatment of HIV-1-infected individuals with a combination of anti-retroviral agents results in sustained suppression of HIV-1 replication, as evidenced by a…”
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Disulfide bridge based PEGylation of proteins by Brocchini, Steve, Godwin, Antony, Balan, Sibu, Choi, Ji-won, Zloh, Mire, Shaunak, Sunil

“…PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation…”
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Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death by Shah, Anand, Kannambath, Shichina, Herbst, Susanne, Rogers, Andrew, Soresi, Simona, Carby, Martin, Reed, Anna, Mostowy, Serge, Fisher, Matthew C, Shaunak, Sunil, Armstrong-James, Darius P

“…Pulmonary aspergillosis is a lethal mold infection in the immunocompromised host. Understanding initial control of infection and how this is altered in the…”
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Improved Synthesis of Linear Poly(ethylenimine) via Low-Temperature Polymerization of 2‑Isopropyl-2-oxazoline in Chlorobenzene by Monnery, Bryn D, Shaunak, Sunil, Thanou, Maya, Steinke, Joachim H. G

“…Linear poly­(ethylenimine) is a cationic polymer that is actively being progressed into clinical trials for gene therapy. The existing synthetic methodology…”
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PEGylation of native disulfide bonds in proteins by Brocchini, Steve, Shaunak, Sunil, Balan, Sibu, Godwin, Antony, Choi, Ji-Won, Zloh, Mire

“…PEGylation has turned proteins into important new biopharmaceuticals. The fundamental problems with the existing approaches to PEGylation are inefficient…”
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Accelerated healing of cutaneous leishmaniasis in non-healing BALB/c mice using water soluble amphotericin B-polymethacrylic acid by Corware, Karina, Harris, Debra, Teo, Ian, Rogers, Matthew, Naresh, Kikkeri, Müller, Ingrid, Shaunak, Sunil

“…Abstract Cutaneous leishmaniasis (CL) is a neglected tropical disease that causes prominent skin scaring. No water soluble, non-toxic, short course and low…”
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Anti-Kaposi’s Sarcoma and Antiangiogenic Activities of Sulfated Dextrins by THORNTON, M, BARKLEY, L, MASON, J. C, SHAUNAK, S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Combining specialist and primary health care teams for HIV positive patients: retrospective and prospective studies by Smith, Suzanne, Robinson, Jane, Hollyer, Justine, Bhatt, Ramesh, Ash, Stephen, Shaunak, Sunil

“…Abstract Objective: To develop and evaluate a model of health care for HIV positive patients involving specialist, hospital based teams and primary health care…”
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Systemic cytokine storm in severe eosinophilic dermatitis by Singanayagam, Anika, Lamb, Lucy, Makinde, Julia E, Teo, Ian, Shaunak, Sunil

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Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation by Shaunak, Sunil, Thomas, Sharyn, Gianasi, Elisabetta, Godwin, Antony, Jones, Emma, Teo, Ian, Mireskandari, Kamiar, Luthert, Philip, Duncan, Ruth, Patterson, Steve, Khaw, Peng, Brocchini, Steve

“…Dendrimers are hyperbranched macromolecules that can be chemically synthesized to have precise structural characteristics. We used anionic, polyamidoamine,…”
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