Search Results - "SHARR, M. M."

Assessment of the absorption, metabolism and excretion of [14C]pasireotide in healthy volunteers using accelerator mass spectrometry by Lin, T.-H., Hu, K., Flarakos, J., Sharr-McMahon, M., Mangold, J. B., He, H., Wang, Y.

“…Purpose Pasireotide (SOM230) is a multireceptor-targeted somatostatin analog designed to have a broader somatostatin receptor binding profile than other…”
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Pilocytic astrocytoma of the adult--clinical features, radiological features and management by Bell, D, Chitnavis, BP, Al-Sarraj, S, Connor, S, Sharr, MM, Gullan, RW

“…Pilocytic astrocytoma is a histological subtype of astrocytoma classically located in the cerebellum of children and young adults. Cases occurring over the age…”
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Spinal meningiomas: a 20-year review by KING, A. T., SHARR, M. M., GULLAN, R. W., BARTLETT, J. R.

“…The long-term outcome of 78 patients with spinal meningiomas operated on over 20 years at a single neurosurgical unit was analysed. Age, sex and tumour…”
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Neurocytoma of the thoracic spinal cord by MARTIN, A. J, SHARR, M. M, TEDDY, P. J, GARDNER, B. P, ROBINSON, S. F. D

“…Central neurocytoma is an unusual tumour that arises in the supratentorial ventricular system of young adults. Similar lesions, termed simply neurocytoma, have…”
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Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors by Zask, A., Gu, Y., Albright, J.D., Du, X., Hogan, M., Levin, J.I., Chen, J.M., Killar, L.M., Sung, A., DiJoseph, J.F., Sharr, M.A., Roth, C.E., Skala, S., Jin, G., Cowling, R., Mohler, K.M., Barone, D., Black, R., March, C., Skotnicki, J.S.

“…Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus…”
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The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups by Levin, J I, Chen, J, Du, M, Hogan, M, Kincaid, S, Nelson, F C, Venkatesan, A M, Wehr, T, Zask, A, DiJoseph, J, Killar, L M, Skala, S, Sung, A, Sharr, M, Roth, C, Jin, G, Cowling, R, Mohler, K M, Black, R A, March, C J, Skotnicki, J S

“…A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and…”
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The discovery of anthranilic acid-based mmp inhibitors. Part 3: incorporation of basic amines by Levin, J.I, Chen, J.M, Du, M.T, Nelson, F.C, Wehr, T, DiJoseph, J.F, Killar, L.M, Skala, S, Sung, A, Sharr, M.A, Roth, C.E, Jin, G, Cowling, R, Di, L, Sherman, M, Xu, Z.B, March, C.J, Mohler, K.M, Black, R.A, Skotnicki, J.S

“…Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine…”
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Unusual radiological appearance of a skull osteoma by MEHTA, J. S, SHARR, M. M, PENNEY, C. C

“…A 24-year-old woman presented with a 7-week history of headache and left frontal scalp swelling. A plain radiograph and CT demonstrated a 2-cm lytic lesion in…”
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Cotton gauze foreign body granuloma following microvascular decompression by PARMAR, D. N., SHARR, M. M.

“…We describe a case of a cotton gauze foreign-body granuloma developing 2 months after microvascular decompression for trigeminal neuralgia and hemifacial…”
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Thoracic intramedullary schwannoma by Brown, K. M., Dean, A., Sharr, M. M.

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An unusual cause of acute labyrinthine failure by Mehta, J S, Sharr, M M

“…We report a case of a 40-year-old man presenting with acute vertigo and deafness. Computed tomography (CT) scanning at initial presentation was normal…”
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The synthesis and biological activity of a novel series of diazepine MMP inhibitors by Levin, Jeremy I., DiJoseph, John F., Killar, Loran M., Sung, Amy, Walter, Thomas, Sharr, Michele A., Roth, Catherine E., Skotnicki, Jerauld S., Albright, J.Donald

“…A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo. A novel series…”
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Sudden right-sided hemiparesis in a middle-aged woman by Mehta, J. S., Sharr, M. M.

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Spontaneous cervical epidural haematoma by Aitken, E M, Lock, B A, Sharr, M M

“…Spontaneous spinal epidural haematoma can occur in the elderly and is a reversible cause of neurological deficit if treated promptly. The diagnosis can be made…”
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Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors by Campbell, David A., Xiao, Xiao-Yi, Harris, David, Ida, Satoru, Mortezaei, Reza, Ngu, Khehyong, Shi, Lihong, Tien, David, Wang, Yongwen, Navre, Marc, Patel, Dinesh V., Sharr, Michele A., DiJoseph, John F., Killar, Loran M., Leone, Christina L., Levin, Jeremy I., Skotnicki, Jerauld S.

“…A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α-mercaptoalcohol in the zinc binding…”
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The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases by Levin, Jeremy I., DiJoseph, John F., Killar, Loran M., Sharr, Michele A., Skotnicki, Jerauld S., Patel, Dinesh V., Xiao, Xiao-Yi, Shi, Lihong, Navre, Marc, Campbell, David A.

“…A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix…”
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The discovery of anthranilic acid-based MMP inhibitors. Part 2 : SAR of the 5-position and P11 groups by LEVIN, J. I, CHEN, J, KILLAR, L. M, SKALA, S, SUNG, A, SHARR, M, ROTH, C, JIN, G, COWLING, R, MOHLER, K. M, BLACK, R. A, MARCH, C. J, DU, M, SKOTNICKI, J. S, HOGAN, M, KINCAID, S, NELSON, F. C, VENKATESAN, A. M, WEHR, T, ZASK, A, DIJOSEPH, J

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The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position by LEVIN, Jeremy I, DU, Mila T, GUIXIAN JIN, COWLING, Rebecca, SKOTNICKI, Jerauld S, DIJOSEPH, John F, KILLAR, Loran M, SUNG, Amy, WALTER, Thomas, SHARR, Michele A, ROTH, Catherine E, MOY, Franklin J, POWERS, Robert

“…A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound,…”
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Perils of a 'true' posterior communicating artery aneurysm by Timothy, J, Sharr, M, Doshi, B

“…Successful 'clipping' of the apparent neck of a posterior communicating artery aneurysm was carried out, but 2 days later the patient had a further haemorrhage…”
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Unusual presentation of a germ cell neoplasm by Timothy, J, Sofat, A, Sharr, M, Doshi, B

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